The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
The Arabidopsis Transcription Factor MYB12 Is a Flavonol-Specific Regulator of Phenylpropanoid Biosynthesis
Open accessAbstract
Comprehensive functional data on plant R2R3-MYB transcription factors is still scarce compared to the manifold of their occurrence. Here, we identified the Arabidopsis (Arabidopsis thaliana) R2R3-MYB transcription factor MYB12 as a flavonol-specific activator of flavonoid biosynthesis. Transient expression in Arabidopsis protoplasts revealed a high degree of functional similarity between MYB12 and the structurally closely related factor P from maize (Zea mays). Both displayed similar target gene specificity, and both activated target gene promoters only in the presence of a functional MYB recognition element. The genes encoding the flavonoid biosynthesis enzymes chalcone synthase, chalcone flavanone isomerase, flavanone 3-hydroxylase, and flavonol synthase were identified as target genes. Hence, our observations further add to the general notion of a close relationship between structure and function of R2R3-MYB factors. High-performance liquid chromatography analyses of myb12 mutant plants and MYB12 overexpression plants demonstrate a tight linkage between the expression level of functional MYB12 and the flavonol content of young seedlings. Quantitative real time reverse transcription-PCR using these mutant plants showed MYB12 to be a transcriptional regulator of CHALCONE SYNTHASE and FLAVONOL SYNTHASE in planta, the gene products of which are indispensable for the biosynthesis of flavonols.
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Metadata
- Authors
- Mehrtens, F., Kranz, H., Bednarek, P., & Weisshaar, B.
- Venue
- Plant Physiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-05-27
- Volume
- 138
- Issue
- 2
- Pages
- 1083-1096
- ISSN
- 0032-0889 (ISSN-L)
- 1532-2548
- OpenAlex
- W1965514968
- Cited by
- 831
- References
- 52
- FWCI
- 6.34
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Mehrtens, F., Kranz, H., Bednarek, P., & Weisshaar, B. (2005). The Arabidopsis Transcription Factor MYB12 Is a Flavonol-Specific Regulator of Phenylpropanoid Biosynthesis. Plant Physiology. https://doi.org/10.1104/pp.104.058032
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