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Cited by 420

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Characterization and Biological Function of the ISOCHORISMATE SYNTHASE2 Gene of Arabidopsis

Open access
Garcion, Christophe, Lohmann, Antje, Lamodière, Elisabeth, Catinot, Jérémy, Buchala, Antony, Doermann, Peter, Métraux, Jean-Pierre·2008·Plant Physiology
DOI 10.1104/pp.108.119420
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Abstract

Salicylic acid (SA) is an important mediator of plant defense response. In Arabidopsis (Arabidopsis thaliana), this compound was proposed to derive mainly from isochorismate, itself produced from chorismate through the activity of ISOCHORISMATE SYNTHASE1 (ICS1). Null ics1 mutants still accumulate some SA, suggesting the existence of an enzymatic activity redundant with ICS1 or of an alternative ICS-independent SA biosynthetic route. Here, we studied the role of ICS2, a second ICS gene of the Arabidopsis genome, in the production of SA. We have shown that ICS2 encodes a functional ICS enzyme and that, similar to ICS1, ICS2 is targeted to the plastids. Comparison of SA accumulation in the ics1, ics2, and ics1 ics2 mutants indicates that ICS2 participates in the synthesis of SA, but in limited amounts that become clearly detectable only when ICS1 is lacking. This unequal redundancy relationship was also observed for phylloquinone, another isochorismate-derived end product. Furthermore, detection of SA in the double ics1 ics2 double mutant that is completely devoid of phylloquinone provides genetic evidence of the existence of an ICS-independent SA biosynthetic pathway in Arabidopsis.

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Metadata

Authors
Garcion, C., Lohmann, A., Lamodière, E., Catinot, J., Buchala, A., Doermann, P., & Métraux, J.-P.
Venue
Plant Physiology
Publisher
Oxford University Press (OUP)
Published
2008-05-01
Volume
147
Issue
3
Pages
1279-1287
ISSN
  • 0032-0889 (ISSN-L)
  • 1532-2548
DOI
10.1104/pp.108.119420
OpenAlex
W2171520124
Cited by
420
References
37
FWCI
3.97
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Characterization and Biological Function of the ISOCHORISMATE SYNTHASE2 Gene of Arabidopsis. https://app.cochat.ai/papers/10.1104/pp.108.119420
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Garcion, C., Lohmann, A., Lamodière, E., Catinot, J., Buchala, A., Doermann, P., & Métraux, J.-P. (2008). Characterization and Biological Function of the ISOCHORISMATE SYNTHASE2 Gene of Arabidopsis. Plant Physiology. https://doi.org/10.1104/pp.108.119420

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