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CLV3 Is Localized to the Extracellular Space, Where It Activates the Arabidopsis CLAVATA Stem Cell Signaling Pathway
Open accessAbstract
Plant growth and development depends on the activity of a continuously replenished pool of stem cells within the shoot apical meristem to supply cells for organogenesis. In Arabidopsis, the stem cell-specific protein CLAVATA3 (CLV3) acts cell nonautonomously to restrict the size of the stem cell population, but the hypothesis that CLV3 acts as an extracellular signaling molecule has not been tested. We used genetic and immunological assays to show that CLV3 localizes to the apoplast and that export to the extracellular space is required for its function in activating the CLV1/CLV2 receptor complex. Apoplastic localization allows CLV3 to signal from the stem cell population to the organizing center in the underlying cells.
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Steeves, T. A., & Sussex, I. M. (1989) · doi:10.1017/cbo9780511626227 · Cited by 1,334
Cited by
Williams, L., Grigg, S. P., Xie, M., Christensen, S., & Fletcher, J. C. (2005) · Development · doi:10.1242/dev.01942 · Cited by 448
Self-citationAuxin and other signals on the move in plants
Robert, H. S., & Friml, J. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.170 · Cited by 252
Carles, C. C., Lertpiriyapong, K., Reville, K., & Fletcher, J. C. (2004) · Genetics · doi:10.1534/genetics.104.028787 · Cited by 88
Self-citationCilia, M., Peter, K. A., Bereman, M. S., Howe, K., Fish, T., Smith, D., Gildow, F., MacCoss, M. J., Thannhauser, T. W., & Gray, S. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048177 · Cited by 35
Metadata
- Authors
- Rojo, E., Sharma, V. K., Kovaleva, V., Raikhel, N. V., & Fletcher, J. C.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-05
- Volume
- 14
- Issue
- 5
- Pages
- 969-977
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2138841154
- Cited by
- 348
- References
- 1
- FWCI
- 36.39
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Rojo, E., Sharma, V. K., Kovaleva, V., Raikhel, N. V., & Fletcher, J. C. (2002). CLV3 Is Localized to the Extracellular Space, Where It Activates the Arabidopsis CLAVATA Stem Cell Signaling Pathway. The Plant Cell. https://doi.org/10.1105/tpc.002196
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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