The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cell Polarity and PIN Protein Positioning in Arabidopsis Require STEROL METHYLTRANSFERASE1 Function
Open accessAbstract
Plants have many polarized cell types, but relatively little is known about the mechanisms that establish polarity. The orc mutant was identified originally by defects in root patterning, and positional cloning revealed that the affected gene encodes STEROL METHYLTRANSFERASE1, which is required for the appropriate synthesis and composition of major membrane sterols. smt1(orc) mutants displayed several conspicuous cell polarity defects. Columella root cap cells revealed perturbed polar positioning of different organelles, and in the smt1(orc) root epidermis, polar initiation of root hairs was more randomized. Polar auxin transport and expression of the auxin reporter DR5-beta-glucuronidase were aberrant in smt1(orc). Patterning defects in smt1(orc) resembled those observed in mutants of the PIN gene family of putative auxin efflux transporters. Consistently, the membrane localization of the PIN1 and PIN3 proteins was disturbed in smt1(orc), whereas polar positioning of the influx carrier AUX1 appeared normal. Our results suggest that balanced sterol composition is a major requirement for cell polarity and auxin efflux in Arabidopsis.
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Cites
A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION
Bligh, E. G., & Dyer, W. J. (1959) · Canadian Journal of Biochemistry and Physiology · doi:10.1139/o59-099 · Cited by 54,751
Cited by
Biogenesis, molecular regulation and function of plant isoprenoids.
Bouvier, F., Rahier, A., & Camara, B. (2005) · Progress in Lipid Research · doi:10.1016/j.plipres.2005.09.003 · Cited by 498
Spatiotemporal asymmetric auxin distribution: a means to coordinate plant development
Tanaka, H., Dhonukshe, P., Brewer, P. B., & Friml, J. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-006-6116-5 · Cited by 361
Self-citationBlakeslee, J. J., Peer, W. A., & Murphy, A. S. (2005) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2005.07.014 · Cited by 292
Titapiwatanakun, B., & Murphy, A. S. (2009) · Journal of Experimental Botany · doi:10.1093/jxb/ern240 · Cited by 156
Posé, D., Castanedo, I., Borsani, O., Nieto, B., Rosado, A., Taconnat, L., Ferrer, A., Dolan, L., Valpuesta, V., & Botella, M. A. (2009) · The Plant Journal · doi:10.1111/j.1365-313x.2009.03849.x · Cited by 145
Metadata
- Authors
- Willemsen, V., Friml, J., Grebe, M., van den Toorn, A., Palme, K., & Scheres, B.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-02-21
- Volume
- 15
- Issue
- 3
- Pages
- 612-625
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2156156748
- Cited by
- 279
- References
- 1
- FWCI
- 28.68
- Type
- journal article
- Language
- en
- Open access
- green
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- Willemsen, V., Friml, J., Grebe, M., van den Toorn, A., Palme, K., & Scheres, B. (2003). Cell Polarity and PIN Protein Positioning in Arabidopsis Require STEROL METHYLTRANSFERASE1 Function. The Plant Cell. https://doi.org/10.1105/tpc.008433
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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