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NPR1 Modulates Cross-Talk between Salicylate- and Jasmonate-Dependent Defense Pathways through a Novel Function in the Cytosol
Open accessAbstract
Plant defenses against pathogens and insects are regulated differentially by cross-communicating signal transduction pathways in which salicylic acid (SA) and jasmonic acid (JA) play key roles. In this study, we investigated the molecular mechanism of the antagonistic effect of SA on JA signaling. Arabidopsis plants unable to accumulate SA produced 25-fold higher levels of JA and showed enhanced expression of the JA-responsive genes LOX2, PDF1.2, and VSP in response to infection by Pseudomonas syringae pv tomato DC3000, indicating that in wild-type plants, pathogen-induced SA accumulation is associated with the suppression of JA signaling. Analysis of the Arabidopsis mutant npr1, which is impaired in SA signal transduction, revealed that the antagonistic effect of SA on JA signaling requires the regulatory protein NPR1. Nuclear localization of NPR1, which is essential for SA-mediated defense gene expression, is not required for the suppression of JA signaling, indicating that cross-talk between SA and JA is modulated through a novel function of NPR1 in the cytosol.
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Cited by
Significance of Inducible Defense-related Proteins in Infected Plants
van Loon, L. C., Rep, M., & Pieterse, C. M. J. (2006) · Annual Review of Phytopathology · doi:10.1146/annurev.phyto.44.070505.143425 · Cited by 3,410
Self-citationInduced systemic resistance by beneficial microbes
Pieterse, C. M. J., Zamioudis, C., Berendsen, R. L., Weller, D. M., Van Wees, S. C. M., & Bakker, P. A. H. M. (2014) · Annual Review of Phytopathology · doi:10.1146/annurev-phyto-082712-102340 · Cited by 3,272
Self-citationDurrant, W. E., & Dong, X. (2004) · Annual Review of Phytopathology · doi:10.1146/annurev.phyto.42.040803.140421 · Cited by 3,184
Self-citationSalicylic acid, a multifaceted hormone to combat disease
Vlot, A. C., Dempsey, D. A., & Klessig, D. F. (2009) · Annual Review of Phytopathology · doi:10.1146/annurev.phyto.050908.135202 · Cited by 2,568
Li, J., Brader, G., & Palva, E. T. (2004) · The Plant Cell · doi:10.1105/tpc.016980 · Cited by 1,207
Metadata
- Authors
- Spoel, S. H., Koornneef, A., Claessens, S. M. C., Korzelius, J. P., Van Pelt, J. A., Mueller, M. J., Buchala, A. J., Métraux, J.-P., Brown, R., Kazan, K., Van Loon, L. C., Dong, X., & Pieterse, C. M. J.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-02-21
- Volume
- 15
- Issue
- 3
- Pages
- 760-770
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2119871519
- Cited by
- 1,227
- References
- 0
- FWCI
- 54.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: NPR1 Modulates Cross-Talk between Salicylate- and Jasmonate-Dependent Defense Pathways through a Novel Function in the Cytosol. https://app.cochat.ai/papers/10.1105/tpc.009159
- The paper
- Spoel, S. H., Koornneef, A., Claessens, S. M. C., Korzelius, J. P., Van Pelt, J. A., Mueller, M. J., Buchala, A. J., Métraux, J.-P., Brown, R., Kazan, K., Van Loon, L. C., Dong, X., & Pieterse, C. M. J. (2003). NPR1 Modulates Cross-Talk between Salicylate- and Jasmonate-Dependent Defense Pathways through a Novel Function in the Cytosol. The Plant Cell. https://doi.org/10.1105/tpc.009159
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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