The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
AUX/IAA Proteins Are Active Repressors, and Their Stability and Activity Are Modulated by Auxin
Open accessAbstract
Aux/IAA genes are early auxin response genes that encode short-lived nuclear proteins with four conserved domains, referred to as I, II, III, and IV. Arabidopsis Aux/IAA proteins repressed transcription on auxin-responsive reporter genes in protoplast transfection assays. Mutations in domain II resulted in increased repression, whereas mutations in domains I and III partially relieved repression. Aux/IAA proteins fused to a heterologous DNA binding domain were targeted to promoters of constitutively expressed reporter genes and actively repressed transcription in an auxin-responsive and dose-dependent manner. In comparison with an unfused luciferase protein, luciferase fused to Aux/IAA proteins displayed less luciferase activity, which further decreased in the presence of auxin in transfected protoplasts. Domain II mutations increased and domain I mutations decreased luciferase activity with the fusion proteins. These results suggested that Aux/IAA proteins function as active repressors by dimerizing with auxin response factors bound to auxin response elements and that early auxin response genes are regulated by auxin-modulated stabilities of Aux/IAA proteins.
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Metadata
- Authors
- Tiwari, S. B., Wang, X.-J., Hagen, G., & Guilfoyle, T. J.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-12
- Volume
- 13
- Issue
- 12
- Pages
- 2809-2822
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2161063064
- Cited by
- 555
- References
- 30
- FWCI
- 23.40
- Type
- journal article
- Language
- en
- Open access
- green
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