The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
The Arabidopsis SLEEPY1 Gene Encodes a Putative F-Box Subunit of an SCF E3 Ubiquitin Ligase[W]
Open accessAbstract
The Arabidopsis SLY1 (SLEEPY1) gene positively regulates gibberellin (GA) signaling. Positional cloning of SLY1 revealed that it encodes a putative F-box protein. This result suggests that SLY1 is the F-box subunit of an SCF E3 ubiquitin ligase that regulates GA responses. The DELLA domain protein RGA (repressor of ga1-3) is a repressor of GA response that appears to undergo GA-stimulated protein degradation. RGA is a potential substrate of SLY1, because sly1 mutations cause a significant increase in RGA protein accumulation even after GA treatment. This result suggests SCFSLY1-targeted degradation of RGA through the 26S proteasome pathway. Further support for this model is provided by the observation that an rga null allele partially suppresses the sly1-10 mutant phenotype. The predicted SLY1 amino acid sequence is highly conserved among plants, indicating a key role in GA response.
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Global Analysis of DELLA Direct Targets in Early Gibberellin Signaling in Arabidopsis
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Metadata
- Authors
- McGinnis, K. M., Thomas, S. G., Soule, J. D., Strader, L. C., Zale, J. M., Sun, T.-P., & Steber, C. M.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-05-01
- Volume
- 15
- Issue
- 5
- Pages
- 1120-1130
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2120854892
- Cited by
- 594
- References
- 61
- FWCI
- 34.03
- Type
- journal article
- Language
- en
- Open access
- bronze
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- McGinnis, K. M., Thomas, S. G., Soule, J. D., Strader, L. C., Zale, J. M., Sun, T.-P., & Steber, C. M. (2003). The Arabidopsis SLEEPY1 Gene Encodes a Putative F-Box Subunit of an SCF E3 Ubiquitin Ligase[W]. The Plant Cell. https://doi.org/10.1105/tpc.010827
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