The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Mre11 Deficiency in Arabidopsis Is Associated with Chromosomal Instability in Somatic Cells and Spo11-Dependent Genome Fragmentation during Meiosis
Open accessAbstract
The Mre11/Rad50/Nbs1 complex is involved in many aspects of chromosome metabolism. Aberrant function of the complex is associated with defects in the DNA checkpoint, double-strand break repair, meiosis, and telomere maintenance. In this article, we report the consequences of Mre11 dysfunction for the stability of mitotic and meiotic chromosomes in Arabidopsis thaliana. Although plants homozygous for a T-DNA insertion in a conserved region of the MRE11 gene are viable, they exhibit growth defects and are infertile. Analysis of mitotic chromosomes prepared from the mutant plants revealed abundant dicentric chromosomes and chromosomal fragments. Fluorescence in situ hybridization showed that anaphase bridges are often formed by homologous chromosome arms. The frequency of chromosome fusions was not reduced in mre11 ku70 double mutants, suggesting that plants possess DNA end-joining activities independent of the Ku70/80 and Mre11 complexes. Cytogenetic examination of pollen mother cells revealed massive chromosome fragmentation and the absence of synapsis in the initial stages of meiosis. The fragmentation was substantially suppressed in mre11 spo11-1 double mutants, indicating that Mre11 is required for repair but not for the induction of Spo11-dependent meiotic DNA breaks in Arabidopsis.
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Carney, J. P., Maser, R. S., Olivares, H., Davis, E. M., Le Beau, M., Yates, J. R., Hays, L., Morgan, W. F., & Petrini, J. H. J. (1998) · Cell · doi:10.1016/s0092-8674(00)81175-7 · Cited by 1,226
The MRE11 complex: at the crossroads of DNA repair and checkpoint signalling
D'Amours, D., & Jackson, S. P. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm805 · Cited by 874
ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
Lim, D.-S., Kim, S.-T., Xu, B., Maser, R. S., Lin, J., Petrini, J. H. J., & Kastan, M. B. (2000) · Nature · doi:10.1038/35007091 · Cited by 786
Dynamics of DNA Double-Strand Breaks Revealed by Clustering of Damaged Chromosome Domains
Aten, J. A., Stap, J., Krawczyk, P. M., van Oven, C. H., Hoebe, R. A., Essers, J., & Kanaar, R. (2004) · Science · doi:10.1126/science.1088845 · Cited by 491
Mre11 Protein Complex Prevents Double-Strand Break Accumulation during Chromosomal DNA Replication
Costanzo, V., Robertson, K., Bibikova, M., Kim, E., Grieco, D., Gottesman, M., Carroll, D., & Gautier, J. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00294-5 · Cited by 239
Cancer predisposition and hematopoietic failure in Rad50 S/S mice
Bender, C. F., Sikes, M. L., Sullivan, R., Huye, L. E., Le Beau, M. M., Roth, D. B., Mirzoeva, O. K., Oltz, E. M., & Petrini, J. H. J. (2002) · Genes & Development · doi:10.1101/gad.1007902 · Cited by 213 · cited 2×
“In addition, chromosome end-to-end associations that retain telomeric DNA at the fusion point were observed in theRad50S/S mouse (Bender et al., 2002).”
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Cited by
The Molecular Biology of Meiosis in Plants
Mercier, R., Mézard, C., Jenczewski, E., Macaisne, N., & Grelon, M. (2015) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-050213-035923 · Cited by 565
Spo11 and the Formation of DNA Double-Strand Breaks in Meiosis
Keeney, S. (2007) · Genome Dynamics and Stability · doi:10.1007/7050_2007_026 · Cited by 330
A DNA topoisomerase VI–like complex initiates meiotic recombination
Vrielynck, N., Chambon, A., Vezon, D., Pereira, L., Chelysheva, L., De Muyt, A., Mézard, C., Mayer, C., & Grelon, M. (2016) · Science · doi:10.1126/science.aad5196 · Cited by 265
Kimura, S., & Sakaguchi, K. (2006) · Chemical Reviews · doi:10.1021/cr040482n · Cited by 167
Double-stranded DNA breaks and gene functions in recombination and meiosis
Li, W., & Ma, H. (2006) · Cell Research · doi:10.1038/sj.cr.7310052 · Cited by 67
Metadata
- Authors
- Puizina, J., Siroky, J., Mokros, P., Schweizer, D., & Riha, K.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-07-16
- Volume
- 16
- Issue
- 8
- Pages
- 1968-1978
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2161874024
- Cited by
- 216
- References
- 6
- FWCI
- 5.69
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Puizina, J., Siroky, J., Mokros, P., Schweizer, D., & Riha, K. (2004). Mre11 Deficiency in Arabidopsis Is Associated with Chromosomal Instability in Somatic Cells and Spo11-Dependent Genome Fragmentation during Meiosis. The Plant Cell. https://doi.org/10.1105/tpc.104.022749
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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