The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
A DNA topoisomerase VI–like complex initiates meiotic recombination
Abstract
A partner protein for meiotic snip: Eukaryotes generate germ cells through meiotic recombination. This process initiates through breaks in genomic DNA catalyzed by the SPO11 protein. Vrielynck et al. and Robert et al. discover that SPO11, like topoisomerase VI enzymes, interacts with a partner protein (see the Perspective by Bouuaert and Keeney). This partner is required for proper meiotic recombination and is found in a wide range of eukaryotes, suggesting that it is a universal feature of the essential recombination step. Science , this issue p. 939 , 943 ; see also p. 916
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ESPript: analysis of multiple sequence alignments in PostScript.
Gouet, P., Courcelle, E., Stuart, D. I., & M√©toz, F. (1999) · Bioinformatics · doi:10.1093/bioinformatics/15.4.305 · Cited by 2,951
Keeney, S., Giroux, C. N., & Kleckner, N. (1997) · Cell · doi:10.1016/s0092-8674(00)81876-0 · Cited by 1,809
In planta Agrobacterium mediated gene transfer by infiltration of adult Arabidopsis thaliana plants
Bechtold, N., Baquero, M., Bonhomme, S., Ferault, M., Horlow, C., Laroche, L., Migdal, M., Mollier, P., Montoro, P., Roux, D., et al. (1993) · HAL · Cited by 1,774
Differential Staining of Aborted and Nonaborted Pollen
Alexander, M. P. (1969) · Stain Technology · doi:10.3109/10520296909063335 · Cited by 1,681
Hu, C.-D., Chinenov, Y., & Kerppola, T. K. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00496-3 · Cited by 1,549
An atypical topoisomerase II from archaea with implications for meiotic recombination
Bergerat, A., de Massy, B., Gadelle, D., Varoutas, P.-C., Nicolas, A., & Forterre, P. (1997) · Nature · doi:10.1038/386414a0 · Cited by 945
GHKL, an emergent ATPase/kinase superfamily
DUTTA, R., & INOUYE, M. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01503-0 · Cited by 762
A Computer Program for Aligning a cDNA Sequence with a Genomic DNA Sequence
Florea, L., Hartzell, G., Zhang, Z., Rubin, G. M., & Miller, W. (1998) · Genome Research · doi:10.1101/gr.8.9.967 · Cited by 729
AtSPO11-1 is necessary for efficient meiotic recombination in plants
Grelon, M. (2001) · The EMBO Journal · doi:10.1093/emboj/20.3.589 · Cited by 511
Self-citationEgea-Cortines, M. (1999) · The EMBO Journal · doi:10.1093/emboj/18.19.5370 · Cited by 500
Cited by
Single-cell RNA-seq uncovers dynamic processes and critical regulators in mouse spermatogenesis
Chen, Y., Zheng, Y., Gao, Y., Lin, Z., Yang, S., Wang, T., Wang, Q., Xie, N., Hua, R., Liu, M., et al. (2018) · Cell Research · doi:10.1038/s41422-018-0074-y · Cited by 420
The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation
Robert, T., Nore, A., Brun, C., Maffre, C., Crimi, B., Guichard, V., Bourbon, H.-M., & de Massy, B. (2016) · Science · doi:10.1126/science.aad5309 · Cited by 302
Structural and functional characterization of the Spo11 core complex
Claeys Bouuaert, C., Tischfield, S. E., Pu, S., Mimitou, E. P., Arias-Palomo, E., Berger, J. M., & Keeney, S. (2021) · Nature Structural & Molecular Biology · doi:10.1038/s41594-020-00534-w · Cited by 87
TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks
Nore, A., Juarez-Martinez, A. B., Clément, J., Brun, C., Diagouraga, B., Laroussi, H., Grey, C., Bourbon, H. M., Kadlec, J., Robert, T., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34799-0 · Cited by 43
Cryo-EM structures of the Spo11 core complex bound to DNA
Yu, Y., Wang, J., Liu, K., Zheng, Z., Arter, M., Claeys Bouuaert, C., Pu, S., Patel, D. J., & Keeney, S. (2025) · Nature Structural & Molecular Biology · doi:10.1038/s41594-024-01382-8 · Cited by 20
Metadata
- Authors
- Vrielynck, N., Chambon, A., Vezon, D., Pereira, L., Chelysheva, L., De Muyt, A., Mézard, C., Mayer, C., & Grelon, M.
- Venue
- Science
- Published
- 2016-02-26
- Volume
- 351
- Issue
- 6276
- Pages
- 939-943
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2290357221
- Cited by
- 265
- References
- 42
- FWCI
- 13.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- Vrielynck, N., Chambon, A., Vezon, D., Pereira, L., Chelysheva, L., De Muyt, A., Mézard, C., Mayer, C., & Grelon, M. (2016). A DNA topoisomerase VI–like complex initiates meiotic recombination. Science. https://doi.org/10.1126/science.aad5196
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