The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Increased Glutathione Biosynthesis Plays a Role in Nickel Tolerance in Thlaspi Nickel Hyperaccumulators[W]
Abstract
Worldwide more than 400 plant species are now known that hyperaccumulate various trace metals (Cd, Co, Cu, Mn, Ni, and Zn), metalloids (As) and nonmetals (Se) in their shoots. Of these, almost one-quarter are Brassicaceae family members, including numerous Thlaspi species that hyperaccumulate Ni up to 3% of there shoot dry weight. We observed that concentrations of glutathione, Cys, and O-acetyl-l-serine (OAS), in shoot tissue, are strongly correlated with the ability to hyperaccumulate Ni in various Thlaspi hyperaccumulators collected from serpentine soils, including Thlaspi goesingense, T. oxyceras, and T. rosulare, and nonaccumulator relatives, including T. perfoliatum, T. arvense, and Arabidopsis thaliana. Further analysis of the Austrian Ni hyperaccumulator T. goesingense revealed that the high concentrations of OAS, Cys, and GSH observed in this hyperaccumulator coincide with constitutively high activity of both serine acetyltransferase (SAT) and glutathione reductase. SAT catalyzes the acetylation of l-Ser to produce OAS, which acts as both a key positive regulator of sulfur assimilation and forms the carbon skeleton for Cys biosynthesis. These changes in Cys and GSH metabolism also coincide with the ability of T. goesingense to both hyperaccumulate Ni and resist its damaging oxidative effects. Overproduction of T. goesingense SAT in the nonaccumulator Brassicaceae family member Arabidopsis was found to cause accumulation of OAS, Cys, and glutathione, mimicking the biochemical changes observed in the Ni hyperaccumulators. In these transgenic Arabidopsis, glutathione concentrations strongly correlate with increased resistance to both the growth inhibitory and oxidative stress induced effects of Ni. Taken together, such evidence supports our conclusion that elevated GSH concentrations, driven by constitutively elevated SAT activity, are involved in conferring tolerance to Ni-induced oxidative stress in Thlaspi Ni hyperaccumulators.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
P HYTOCHELATINS AND M ETALLOTHIONEINS : Roles in Heavy Metal Detoxification and Homeostasis
Cobbett, C., & Goldsbrough, P. (2002) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.53.100301.135154 · Cited by 2,518
The molecular physiology of heavy metal transport in the Zn/Cd hyperaccumulator Thlaspi caerulescens
Pence, N. S., Larsen, P. B., Ebbs, S. D., Letham, D. L. D., Lasat, M. M., Garvin, D. F., Eide, D., & Kochian, L. V. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.9.4956 · Cited by 748
Becher, M., Talke, I. N., Krall, L., & Krämer, U. (2004) · The Plant Journal · doi:10.1046/j.1365-313x.2003.01959.x · Cited by 568
Weber, M., Harada, E., Vess, C., Roepenack‐Lahaye, E. V., & Clemens, S. (2004) · The Plant Journal · doi:10.1046/j.1365-313x.2003.01960.x · Cited by 440
Sebertia acuminata : A Hyperaccumulator of Nickel from New Caledonia
Jaffré, T., Brooks, R. R., Lee, J., & Reeves, R. D. (1976) · Science · doi:10.1126/science.193.4253.579 · Cited by 410
Mechanism of Heavy Metal Ion Activation of Phytochelatin (PC) Synthase
Vatamaniuk, O. K., Mari, S., Lu, Y.-P., & Rea, P. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002997200 · Cited by 390 · cited 1×
“However, PCs are not involved in resistance to Ni, Co, and Zn in A. thaliana (Howden and Cobbett, 1992; Ha et al., 1999; Vatamaniuk et al., 2000; for review, see Cobbett, 2000).”
BackgroundAssunção, A. G. L., Martins, P. D. C., De Folter, S., Vooijs, R., Schat, H., & Aarts, M. G. M. (2001) · Plant, Cell & Environment · doi:10.1111/j.1365-3040.2001.00666.x · Cited by 350
BERT, V., MACNAIR, M. R., DE LAGUERIE, P., SAUMITOU‐LAPRADE, P., & PETIT, D. (2000) · New Phytologist · doi:10.1046/j.1469-8137.2000.00634.x · Cited by 225 · cited 1×
“Considering metal hyperaccumulators usually complete their entire life cycle on soils enriched in Ni or Zn, it is not unexpected that the traits required for metal hyperaccumulation in these environments are constitutive (Reeves and Baker, 1984; Boyd andMartens, 1998; Bert et al., 2000).”
BackgroundEbbs, S., Ahner, B., Kochian, L., & Lau, I. (2002) · Planta · doi:10.1007/s004250100650 · Cited by 214
Cited by
Metal hyperaccumulation in plants
Krämer, U. (2010) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-042809-112156 · Cited by 1,284
Salicylic Acid: A Plant Hormone
(2007) · Springer eBooks · doi:10.1007/1-4020-5184-0 · Cited by 473
VAN DE MORTEL, J. E., SCHAT, H., MOERLAND, P. D., VAN THEMAAT, E. V. L., VAN DER ENT, S., BLANKESTIJN, H., GHANDILYAN, A., TSIATSIANI, S., & AARTS, M. G. M. (2008) · Plant, Cell & Environment · doi:10.1111/j.1365-3040.2007.01764.x · Cited by 326
AtATM3 Is Involved in Heavy Metal Resistance in Arabidopsis
Kim, D.-Y., Bovet, L., Kushnir, S., Noh, E. W., Martinoia, E., & Lee, Y. (2006) · Plant Physiology · doi:10.1104/pp.105.074146 · Cited by 317
Plant Adaptation and Phytoremediation
(2010) · Springer eBooks · doi:10.1007/978-90-481-9370-7 · Cited by 308
Metadata
- Authors
- Freeman, J. L., Persans, M. W., Nieman, K., Albrecht, C., Peer, W., Pickering, I. J., & Salt, D. E.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-08-01
- Volume
- 16
- Issue
- 8
- Pages
- 2176-2191
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2023054478
- Cited by
- 492
- References
- 9
- FWCI
- 6.56
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Increased Glutathione Biosynthesis Plays a Role in Nickel Tolerance in Thlaspi Nickel Hyperaccumulators[W]. https://app.cochat.ai/papers/10.1105/tpc.104.023036
- The paper
- Freeman, J. L., Persans, M. W., Nieman, K., Albrecht, C., Peer, W., Pickering, I. J., & Salt, D. E. (2004). Increased Glutathione Biosynthesis Plays a Role in Nickel Tolerance in Thlaspi Nickel Hyperaccumulators[W]. The Plant Cell. https://doi.org/10.1105/tpc.104.023036
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
