The DOI matches its Crossref record; 148 of the 148 references it cites were found in a registry or an index.
Arabidopsis Nitric Oxide Synthase1 Is Targeted to Mitochondria and Protects against Oxidative Damage and Dark-Induced Senescence
Abstract
The Arabidopsis thaliana protein nitric oxide synthase1 (NOS1) is needed for nitric oxide (NO) synthesis and signaling during defense responses, hormonal signaling, and flowering. The cellular localization of NOS1 was examined because it is predicted to be a mitochondrial protein. NOS1-green fluorescent protein fusions were localized by confocal microscopy to mitochondria in roots. Isolated mitochondria from leaves of wild-type plants supported Arg-stimulated NO synthesis that could be inhibited by NOS inhibitors and quenched by a NO scavenger; this NOS activity is absent in mitochondria isolated from nos1 mutant plants. Because mitochondria are a source of reactive oxygen species (ROS), which participate in senescence and programmed cell death, these parameters were examined in the nos1 mutant. Dark-induced senescence of detached leaves and intact plants progressed more rapidly in the mutant compared with the wild type. Hydrogen peroxide, superoxide anion, oxidized lipid, and oxidized protein levels were all higher in the mutant. These results demonstrate that NOS1 is a mitochondrial NOS that reduces ROS levels, mitigates oxidative damage, and acts as an antisenescence agent.
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Cites
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Cited by
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Nitric Oxide in Plants: Production and Cross-talk with Ca2+ Signaling
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Metadata
- Authors
- Guo, F.-Q., & Crawford, N. M.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-11-04
- Volume
- 17
- Issue
- 12
- Pages
- 3436-3450
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2134733352
- Cited by
- 406
- References
- 148
- FWCI
- 36.71
- Type
- journal article
- Language
- en
- Open access
- closed
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- Guo, F.-Q., & Crawford, N. M. (2005). Arabidopsis Nitric Oxide Synthase1 Is Targeted to Mitochondria and Protects against Oxidative Damage and Dark-Induced Senescence. The Plant Cell. https://doi.org/10.1105/tpc.105.037770
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