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Cited by 548

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

Caught Red-Handed:Rc Encodes a Basic Helix-Loop-Helix Protein Conditioning Red Pericarp in Rice

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Sweeney, Megan T., Thomson, Michael J., Pfeil, Bernard E., McCouch, Susan·2006·The Plant Cell

Abstract

Rc is a domestication-related gene required for red pericarp in rice (Oryza sativa). The red grain color is ubiquitous among the wild ancestors of O. sativa, in which it is closely associated with seed shattering and dormancy. Rc encodes a basic helix-loop-helix (bHLH) protein that was fine-mapped to an 18.5-kb region on rice chromosome 7 using a cross between Oryza rufipogon (red pericarp) and O. sativa cv Jefferson (white pericarp). Sequencing of the alleles from both mapping parents as well as from two independent genetic stocks of Rc revealed that the dominant red allele differed from the recessive white allele by a 14-bp deletion within exon 6 that knocked out the bHLH domain of the protein. A premature stop codon was identified in the second mutant stock that had a light red pericarp. RT-PCR experiments confirmed that the Rc gene was expressed in both red- and white-grained rice but that a shortened transcript was present in white varieties. Phylogenetic analysis, supported by comparative mapping in rice and maize (Zea mays), showed that Rc, a positive regulator of proanthocyanidin, is orthologous with INTENSIFIER1, a negative regulator of anthocyanin production in maize, and is not in the same clade as rice bHLH anthocyanin regulators.

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Metadata

Authors
Sweeney, M. T., Thomson, M. J., Pfeil, B. E., & McCouch, S.
Venue
The Plant Cell
Published
2006-01-06
Volume
18
Issue
2
Pages
283-294
ISSN
  • 1040-4651 (ISSN-L)
  • 1532-298X
OpenAlex
W2110811926
Cited by
548
References
48
FWCI
11.13
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Caught Red-Handed:Rc Encodes a Basic Helix-Loop-Helix Protein Conditioning Red Pericarp in Rice. https://app.cochat.ai/papers/10.1105/tpc.105.038430
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Sweeney, M. T., Thomson, M. J., Pfeil, B. E., & McCouch, S. (2006). Caught Red-Handed:Rc Encodes a Basic Helix-Loop-Helix Protein Conditioning Red Pericarp in Rice. The Plant Cell. https://doi.org/10.1105/tpc.105.038430

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