The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
A Network of Local and Redundant Gene Regulation Governs Arabidopsis Seed Maturation
Open accessAbstract
In Arabidopsis thaliana, four major regulators (ABSCISIC ACID INSENSITIVE3 [ABI3], FUSCA3 [FUS3], LEAFY COTYLEDON1 [LEC1], and LEC2) control most aspects of seed maturation, such as accumulation of storage compounds, cotyledon identity, acquisition of desiccation tolerance, and dormancy. The molecular basis for complex genetic interactions among these regulators is poorly understood. By analyzing ABI3 and FUS3 expression in various single, double, and triple maturation mutants, we have identified multiple regulatory links among all four genes. We found that one of the major roles of LEC2 was to upregulate FUS3 and ABI3. The lec2 mutation is responsible for a dramatic decrease in ABI3 and FUS3 expression, and most lec2 phenotypes can be rescued by ABI3 or FUS3 constitutive expression. In addition, ABI3 and FUS3 positively regulate themselves and each other, thereby forming feedback loops essential for their sustained and uniform expression in the embryo. Finally, LEC1 also positively regulates ABI3 and FUS3 in the cotyledons. Most of the genetic controls discovered were found to be local and redundant, explaining why they had previously been overlooked. This works establishes a genetic framework for seed maturation, organizing the key regulators of this process into a hierarchical network. In addition, it offers a molecular explanation for the puzzling variable features of lec2 mutant embryos.
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Citations
Cites
Noise in eukaryotic gene expression
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A genomic regulatory network for development
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Thattai, M., & van Oudenaarden, A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151588598 · Cited by 1,428 · cited 1×
“Our results therefore not only provide an explanation for a puzzling seed phenotype but also represent an experimental confirmation of theoretical studies of general interest.”
ResultArabidopsis LEAFY COTYLEDON1 Is Sufficient to Induce Embryo Development in Vegetative Cells
Lotan, T., Ohto, M.-A., Yee, K. M., West, M. A. L., Lo, R., Kwong, R. W., Yamagishi, K., Fischer, R. L., Goldberg, R. B., & Harada, J. J. (1998) · Cell · doi:10.1016/s0092-8674(00)81463-4 · Cited by 1,070
Isolation of the Arabidopsis ABI3 gene by positional cloning.
Giraudat, J., Hauge, B. M., Valon, C., Smalle, J., Parcy, F., & Goodman, H. M. (1992) · The Plant Cell · doi:10.1105/tpc.4.10.1251 · Cited by 1,029
Self-citationGene regulatory networks for development
Levine, M., & Davidson, E. H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408031102 · Cited by 796
LEAFY COTYLEDON2 encodes a B3 domain transcription factor that induces embryo development
Stone, S. L., Kwong, L. W., Yee, K. M., Pelletier, J., Lepiniec, L., Fischer, R. L., Goldberg, R. B., & Harada, J. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.201413498 · Cited by 786
The Viviparous-1 developmental gene of maize encodes a novel transcriptional activator
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Plant Embryogenesis: Zygote to Seed
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Self-citation
Cited by
Molecular Aspects of Seed Dormancy
Finkelstein, R., Reeves, W., Ariizumi, T., & Steber, C. (2008) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.59.032607.092740 · Cited by 1,379
Molecular networks regulating Arabidopsis seed maturation, after‐ripening, dormancy and germination
Holdsworth, M. J., Bentsink, L., & Soppe, W. J. J. (2008) · New Phytologist · doi:10.1111/j.1469-8137.2008.02437.x · Cited by 964
LEAFY COTYLEDON1 Is a Key Regulator of Fatty Acid Biosynthesis in Arabidopsis
Mu, J., Tan, H., Zheng, Q., Fu, F., Liang, Y., Zhang, J., Yang, X., Wang, T., Chong, K., Wang, X.-J., et al. (2008) · Plant Physiology · doi:10.1104/pp.108.126342 · Cited by 411
Horstman, A., Li, M., Heidmann, I., Weemen, M., Chen, B., Muino, J. M., Angenent, G. C., & Boutilier, K. (2017) · Plant Physiology · doi:10.1104/pp.17.00232 · Cited by 361
Bies-Ethève, N., Gaubier-Comella, P., Debures, A., Lasserre, E., Jobet, E., Raynal, M., Cooke, R., & Delseny, M. (2008) · Plant Molecular Biology · doi:10.1007/s11103-008-9304-x · Cited by 308
Metadata
- Authors
- To, A., Valon, C., Savino, G., Guilleminot, J., Devic, M., Giraudat, J., & Parcy, F.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-05-26
- Volume
- 18
- Issue
- 7
- Pages
- 1642-1651
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2127632851
- Cited by
- 398
- References
- 34
- FWCI
- 28.66
- Type
- journal article
- Language
- en
- Open access
- green
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- To, A., Valon, C., Savino, G., Guilleminot, J., Devic, M., Giraudat, J., & Parcy, F. (2006). A Network of Local and Redundant Gene Regulation Governs Arabidopsis Seed Maturation. The Plant Cell. https://doi.org/10.1105/tpc.105.039925
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