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Cited by 310

The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.

Arabidopsis WEE1 Kinase Controls Cell Cycle Arrest in Response to Activation of the DNA Integrity Checkpoint

Open access
De Schutter, Kristof, Joubès, Jérôme, Cools, Toon, Verkest, Aurine, Corellou, Florence, Babiychuk, Elena, Van Der Schueren, Els, Beeckman, Tom, Kushnir, Sergeï, Inzé, Dirk, De Veylder, Lieven·2007·The Plant Cell
DOI 10.1105/tpc.106.045047
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Abstract

Upon the incidence of DNA stress, the ataxia telangiectasia–mutated (ATM) and Rad3-related (ATR) signaling kinases activate a transient cell cycle arrest that allows cells to repair DNA before proceeding into mitosis. Although the ATM-ATR pathway is highly conserved over species, the mechanisms by which plant cells stop their cell cycle in response to the loss of genome integrity are unclear. We demonstrate that the cell cycle regulatory WEE1 kinase gene of Arabidopsis thaliana is transcriptionally activated upon the cessation of DNA replication or DNA damage in an ATR- or ATM-dependent manner, respectively. In accordance with a role for WEE1 in DNA stress signaling, WEE1-deficient plants showed no obvious cell division or endoreduplication phenotype when grown under nonstress conditions but were hypersensitive to agents that impair DNA replication. Induced WEE1 expression inhibited plant growth by arresting dividing cells in the G2-phase of the cell cycle. We conclude that the plant WEE1 gene is not rate-limiting for cycle progression under normal growth conditions but is a critical target of the ATR-ATM signaling cascades that inhibit the cell cycle upon activation of the DNA integrity checkpoints, coupling mitosis to DNA repair in cells that suffer DNA damage.

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Crossref · 10.1105/tpc.106.045047

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Metadata

Authors
De Schutter, K., Joubès, J., Cools, T., Verkest, A., Corellou, F., Babiychuk, E., Van Der Schueren, E., Beeckman, T., Kushnir, S., Inzé, D., & De Veylder, L.
Venue
The Plant Cell
Publisher
Oxford University Press (OUP)
Published
2007-01-01
Volume
19
Issue
1
Pages
211-225
ISSN
  • 1040-4651 (ISSN-L)
  • 1532-298X
DOI
10.1105/tpc.106.045047
OpenAlex
W2159185219
Cited by
310
References
65
FWCI
5.99
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Arabidopsis WEE1 Kinase Controls Cell Cycle Arrest in Response to Activation of the DNA Integrity Checkpoint. https://app.cochat.ai/papers/10.1105/tpc.106.045047
The paper
De Schutter, K., Joubès, J., Cools, T., Verkest, A., Corellou, F., Babiychuk, E., Van Der Schueren, E., Beeckman, T., Kushnir, S., Inzé, D., & De Veylder, L. (2007). Arabidopsis WEE1 Kinase Controls Cell Cycle Arrest in Response to Activation of the DNA Integrity Checkpoint. The Plant Cell. https://doi.org/10.1105/tpc.106.045047

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.