The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
The Coactivator Function of Arabidopsis NPR1 Requires the Core of Its BTB/POZ Domain and the Oxidation of C-Terminal Cysteines
Open accessAbstract
NONEXPRESSOR OF PATHOGENESIS-RELATED GENES1 (NPR1) regulates systemic acquired resistance (SAR) in Arabidopsis thaliana, and current models propose that after treatment with salicylic acid (SA), Cys-82 and Cys-216 of NPR1 are reduced, leading to nuclear import. The interaction of nucleus-localized NPR1 with TGA transcription factors results in the activation of defense genes, including the SAR marker PATHOGENESIS-RELATED-1 (PR-1), and the deployment of SAR. Little is known about how TGA factors or NPR1 regulate transcription or whether a TGA-NPR1 complex forms on DNA. We show that TGA2 and NPR1 are recruited to PR-1 independently of each other and of SA treatment. Consistent with the result that a triple knockout in TGA2/5/6 derepresses PR-1, in vivo plant transcription assays revealed that TGA2 is not an autonomous transcription activator but is a transcriptional repressor in both untreated and SA-treated cells. However, after stimulation with SA, TGA2 is incorporated into a transactivating complex with NPR1, forming an enhanceosome that requires the core of the NPR1 BTB/POZ domain (residues 80 to 91) and the oxidation of NPR1 Cys-521 and Cys-529. These Cys residues are found in a new type of transactivation domain that we term Cys-oxidized. These data further our understanding of the mechanism by which TGA2 and NPR1 activate Arabidopsis PR-1.
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Cites
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Cited by
Salicylic acid, a multifaceted hormone to combat disease
Vlot, A. C., Dempsey, D. A., & Klessig, D. F. (2009) · Annual Review of Phytopathology · doi:10.1146/annurev.phyto.050908.135202 · Cited by 2,568
Systemic Acquired Resistance: Turning Local Infection into Global Defense
Fu, Z. Q., & Dong, X. (2013) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-042811-105606 · Cited by 1,524
Salicylic Acid: Biosynthesis and Signaling
Peng, Y., Yang, J., Li, X., & Zhang, Y. (2021) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-081320-092855 · Cited by 560
Salicylic Acid and its Function in Plant ImmunityF
An, C., & Mou, Z. (2011) · Journal of Integrative Plant Biology · doi:10.1111/j.1744-7909.2011.01043.x · Cited by 517
Meyer, Y., Belin, C., Delorme-Hinoux, V., Reichheld, J.-P., & Riondet, C. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4327 · Cited by 406
Metadata
- Authors
- Rochon, A., Boyle, P., Wignes, T., Fobert, P. R., & Després, C.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-12-01
- Volume
- 18
- Issue
- 12
- Pages
- 3670-3685
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2162702318
- Cited by
- 309
- References
- 49
- FWCI
- 13.94
- Type
- journal article
- Language
- en
- Open access
- green
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- Rochon, A., Boyle, P., Wignes, T., Fobert, P. R., & Després, C. (2007). The Coactivator Function of Arabidopsis NPR1 Requires the Core of Its BTB/POZ Domain and the Oxidation of C-Terminal Cysteines. The Plant Cell. https://doi.org/10.1105/tpc.106.046953
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