The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
MTA Is an Arabidopsis Messenger RNA Adenosine Methylase and Interacts with a Homolog of a Sex-Specific Splicing Factor
Open accessAbstract
N 6-Methyladenosine is a ubiquitous modification identified in the mRNA of numerous eukaryotes, where it is present within both coding and noncoding regions. However, this base modification does not alter the coding capacity, and its biological significance remains unclear. We show that Arabidopsis thaliana mRNA contains N 6-methyladenosine at levels similar to those previously reported for animal cells. We further show that inactivation of the Arabidopsis ortholog of the yeast and human mRNA adenosine methylase (MTA) results in failure of the developing embryo to progress past the globular stage. We also demonstrate that the arrested seeds are deficient in mRNAs containing N 6-methyladenosine. Expression of MTA is strongly associated with dividing tissues, particularly reproductive organs, shoot meristems, and emerging lateral roots. Finally, we show that MTA interacts in vitro and in vivo with At FIP37, a homolog of the Drosophila protein FEMALE LETHAL2D and of human WILMS' TUMOUR1-ASSOCIATING PROTEIN. The results reported here provide direct evidence for an essential function for N 6-methyladenosine in a multicellular eukaryote, and the interaction with At FIP37 suggests possible RNA processing events that might be regulated or altered by this base modification.
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Cites
Identification of Methylated Nucleosides in Messenger RNA from Novikoff Hepatoma Cells
Desrosiers, R., Friderici, K., & Rottman, F. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.10.3971 · Cited by 1,757
Nakagawa, T., Kurose, T., Hino, T., Tanaka, K., Kawamukai, M., Niwa, Y., Toyooka, K., Matsuoka, K., Jinbo, T., & Kimura, T. (2007) · Journal of Bioscience and Bioengineering · doi:10.1263/jbb.104.34 · Cited by 1,643
Bokar, J. A., Shambaugh, M. E., Polayes, D. A., Matera, A. G., & ROTTMAN, F. M. (1997) · PubMed Central · Cited by 955
Comprehensive proteomic analysis of the human spliceosome
Zhou, Z., Licklider, L. J., Gygi, S. P., & Reed, R. (2002) · Nature · doi:10.1038/nature01031 · Cited by 893
tRNA’s Wobble Decoding of the Genome: 40 Years of Modification
Agris, P. F., Vendeix, F. A. P., & Graham, W. D. (2007) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.11.046 · Cited by 543
Hammes, A., Guo, J.-K., Lutsch, G., Leheste, J.-R., Landrock, D., Ziegler, U., Gubler, M.-C., & Schedl, A. (2001) · Cell · doi:10.1016/s0092-8674(01)00453-6 · Cited by 541
Larsson, S. H., Charlieu, J.-P., Miyagawa, K., Engelkamp, D., Rassoulzadegan, M., Ross, A., Cuzin, F., Heyningen, V. V., & Hastie, N. D. (1995) · Cell · doi:10.1016/0092-8674(95)90392-5 · Cited by 504
Modified nucleosides and bizarre 5′-termini in mouse myeloma mRNA
Adams, J. M., & Cory, S. (1975) · Nature · doi:10.1038/255028a0 · Cited by 476
The Fate of dsRNA in the Nucleus
Zhang, Z., & Carmichael, G. G. (2001) · Cell · doi:10.1016/s0092-8674(01)00466-4 · Cited by 469
Existence of methylated messenger RNA in mouse L cells
Perry, R. P., & Kelley, D. E. (1974) · Cell · doi:10.1016/0092-8674(74)90153-6 · Cited by 437
Cited by
Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
Dominissini, D., Moshitch-Moshkovitz, S., Schwartz, S., Salmon-Divon, M., Ungar, L., Osenberg, S., Cesarkas, K., Jacob-Hirsch, J., Amariglio, N., Kupiec, M., et al. (2012) · Nature · doi:10.1038/nature11112 · Cited by 4,884
N6-methyladenosine-dependent regulation of messenger RNA stability
Wang, X., Lu, Z., Gomez, A., Hon, G. C., Yue, Y., Han, D., Fu, Y., Parisien, M., Dai, Q., Jia, G., et al. (2014) · Nature · doi:10.1038/nature12730 · Cited by 4,558
ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
Zheng, G., Dahl, J. A., Niu, Y., Fedorcsak, P., Huang, C.-M., Li, C. J., Vågbø, C. B., Shi, Y., Wang, W.-L., Song, S.-H., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2012.10.015 · Cited by 3,550
“ALKBH5 Is a Mammalian m6A RNA Demethylase been shown through the knockdown of MT-A70—a key component of the proposed methyltransferase complex (Bokar et al., 1997)—in HeLa and plant cells, which led to apoptosis in HeLa cells and arrested development in plants (Bokar, 2005; Zhong et al., 2008).”
N6-methyladenosine Modulates Messenger RNA Translation Efficiency
Wang, X., Zhao, B. S., Roundtree, I. A., Lu, Z., Han, D., Ma, H., Weng, X., Chen, K., Shi, H., & He, C. (2015) · Cell · doi:10.1016/j.cell.2015.05.014 · Cited by 3,483
A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
Liu, J., Yue, Y., Han, D., Wang, X., Fu, Y., Zhang, L., Jia, G., Yu, M., Lu, Z., Deng, X., et al. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1432 · Cited by 3,433
Metadata
- Authors
- Zhong, S., Li, H., Bodi, Z., Button, J., Vespa, L., Herzog, M., & Fray, R. G.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-05-01
- Volume
- 20
- Issue
- 5
- Pages
- 1278-1288
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2164852392
- Cited by
- 668
- References
- 49
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Zhong, S., Li, H., Bodi, Z., Button, J., Vespa, L., Herzog, M., & Fray, R. G. (2008). MTA Is an Arabidopsis Messenger RNA Adenosine Methylase and Interacts with a Homolog of a Sex-Specific Splicing Factor. The Plant Cell. https://doi.org/10.1105/tpc.108.058883
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