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Genomic and Coexpression Analyses Predict Multiple Genes Involved in Triterpene Saponin Biosynthesis in Medicago truncatula
Open accessAbstract
Saponins, an important group of bioactive plant natural products, are glycosides of triterpenoid or steroidal aglycones (sapogenins). Saponins possess many biological activities, including conferring potential health benefits for humans. However, most of the steps specific for the biosynthesis of triterpene saponins remain uncharacterized at the molecular level. Here, we use comprehensive gene expression clustering analysis to identify candidate genes involved in the elaboration, hydroxylation, and glycosylation of the triterpene skeleton in the model legume Medicago truncatula. Four candidate uridine diphosphate glycosyltransferases were expressed in Escherichia coli, one of which (UGT73F3) showed specificity for multiple sapogenins and was confirmed to glucosylate hederagenin at the C28 position. Genetic loss-of-function studies in M. truncatula confirmed the in vivo function of UGT73F3 in saponin biosynthesis. This report provides a basis for future studies to define genetically the roles of multiple cytochromes P450 and glycosyltransferases in triterpene saponin biosynthesis in Medicago.
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Cites
Statistical significance for genomewide studies
Storey, J. D., & Tibshirani, R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1530509100 · Cited by 9,692
Decoding genes with coexpression networks and metabolomics – ‘majority report by precogs’
Saito, K., Hirai, M. Y., & Yonekura-Sakakibara, K. (2008) · Trends in Plant Science · doi:10.1016/j.tplants.2007.10.006 · Cited by 327
Cited by
Triterpene Biosynthesis in Plants
Thimmappa, R., Geisler, K., Louveau, T., O'Maille, P., & Osbourn, A. (2014) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-050312-120229 · Cited by 803
Molecular activities, biosynthesis and evolution of triterpenoid saponins
Augustin, J. M., Kuzina, V., Andersen, S. B., & Bak, S. (2011) · Phytochemistry · doi:10.1016/j.phytochem.2011.01.015 · Cited by 799
Protein degradation – an alternative respiratory substrate for stressed plants
Araújo, W. L., Tohge, T., Ishizaki, K., Leaver, C. J., & Fernie, A. R. (2011) · Trends in Plant Science · doi:10.1016/j.tplants.2011.05.008 · Cited by 438
Plant chemical defense: at what cost?
Neilson, E. H., Goodger, J. Q. D., Woodrow, I. E., & Møller, B. L. (2013) · Trends in Plant Science · doi:10.1016/j.tplants.2013.01.001 · Cited by 385
Seki, H., Sawai, S., Ohyama, K., Mizutani, M., Ohnishi, T., Sudo, H., Fukushima, E. O., Akashi, T., Aoki, T., Saito, K., et al. (2011) · The Plant Cell · doi:10.1105/tpc.110.082685 · Cited by 331
Metadata
- Authors
- Naoumkina, M. A., Modolo, L. V., Huhman, D. V., Urbanczyk-Wochniak, E., Tang, Y., Sumner, L. W., & Dixon, R. A.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-03-01
- Volume
- 22
- Issue
- 3
- Pages
- 850-866
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2115579638
- Cited by
- 183
- References
- 2
- FWCI
- 4.73
- Type
- journal article
- Language
- en
- Open access
- green
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- Naoumkina, M. A., Modolo, L. V., Huhman, D. V., Urbanczyk-Wochniak, E., Tang, Y., Sumner, L. W., & Dixon, R. A. (2010). Genomic and Coexpression Analyses Predict Multiple Genes Involved in Triterpene Saponin Biosynthesis in Medicago truncatula. The Plant Cell. https://doi.org/10.1105/tpc.109.073270
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