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The FLF MADS Box Gene: A Repressor of Flowering in Arabidopsis Regulated by Vernalization and Methylation
Open accessAbstract
A MADS box gene, FLF (for FLOWERING LOCUS F ), isolated from a late-flowering, T-DNA-tagged Arabidopsis mutant, is a semidominant gene encoding a repressor of flowering. The FLF gene appears to integrate the vernalization-dependent and autonomous flowering pathways because its expression is regulated by genes in both pathways. The level of FLF mRNA is downregulated by vernalization and by a decrease in genomic DNA methylation, which is consistent with our previous suggestion that vernalization acts to induce flowering through changes in gene activity that are mediated through a reduction in DNA methylation. The flf-1 mutant requires a greater than normal amount of an exogenous gibberellin (GA3) to decrease flowering time compared with the wild type or with vernalization-responsive late-flowering mutants, suggesting that the FLF gene product may block the promotion of flowering by GAs. FLF maps to a region on chromosome 5 near the FLOWERING LOCUS C gene, which is a semidominant repressor of flowering in late-flowering ecotypes of Arabidopsis.
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Citations
Cited by
Jaenisch, R., & Bird, A. (2003) · Nature Genetics · doi:10.1038/ng1089 · Cited by 6,325
The genetic basis of flowering responses to seasonal cues
Andrés, F., & Coupland, G. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3291 · Cited by 1,538
The wheat and barley vernalization gene VRN3 is an orthologue of FT
Yan, L., Fu, D., Li, C., Blechl, A., Tranquilli, G., Bonafede, M., Sanchez, A., Valarik, M., Yasuda, S., & Dubcovsky, J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607142103 · Cited by 1,121
Johanson, U., West, J., Lister, C., Michaels, S., Amasino, R., & Dean, C. (2000) · Science · doi:10.1126/science.290.5490.344 · Cited by 1,019
Seasonal and developmental timing of flowering
Amasino, R. (2010) · The Plant Journal · doi:10.1111/j.1365-313x.2010.04148.x · Cited by 894
Metadata
- Authors
- Sheldon, C. C., Burn, J. E., Perez, P. P., Metzger, J., Edwards, J. A., Peacock, W. J., & Dennis, E. S.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-03
- Volume
- 11
- Issue
- 3
- Pages
- 445-458
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2114800743
- Cited by
- 971
- References
- 0
- FWCI
- 50.18
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Sheldon, C. C., Burn, J. E., Perez, P. P., Metzger, J., Edwards, J. A., Peacock, W. J., & Dennis, E. S. (1999). The FLF MADS Box Gene: A Repressor of Flowering in Arabidopsis Regulated by Vernalization and Methylation. The Plant Cell. https://doi.org/10.1105/tpc.11.3.445
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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