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The Rice Resistance Protein Pair RGA4/RGA5 Recognizes the Magnaporthe oryzae Effectors AVR-Pia and AVR1-CO39 by Direct Binding
Open accessAbstract
Resistance (R) proteins recognize pathogen avirulence (Avr) proteins by direct or indirect binding and are multidomain proteins generally carrying a nucleotide binding (NB) and a leucine-rich repeat (LRR) domain. Two NB-LRR protein-coding genes from rice (Oryza sativa), RGA4 and RGA5, were found to be required for the recognition of the Magnaporthe oryzae effector AVR1-CO39. RGA4 and RGA5 also mediate recognition of the unrelated M. oryzae effector AVR-Pia, indicating that the corresponding R proteins possess dual recognition specificity. For RGA5, two alternative transcripts, RGA5-A and RGA5-B, were identified. Genetic analysis showed that only RGA5-A confers resistance, while RGA5-B is inactive. Yeast two-hybrid, coimmunoprecipitation, and fluorescence resonance energy transfer–fluorescence lifetime imaging experiments revealed direct binding of AVR-Pia and AVR1-CO39 to RGA5-A, providing evidence for the recognition of multiple Avr proteins by direct binding to a single R protein. Direct binding seems to be required for resistance as an inactive AVR-Pia allele did not bind RGA5-A. A small Avr interaction domain with homology to the Avr recognition domain in the rice R protein Pik-1 was identified in the C terminus of RGA5-A. This reveals a mode of Avr protein recognition through direct binding to a novel, non-LRR interaction domain.
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Metadata
- Authors
- Cesari, S., Thilliez, G., Ribot, C., Chalvon, V., Michel, C., Jauneau, A., Rivas, S., Alaux, L., Kanzaki, H., Okuyama, Y., Morel, J.-B., Fournier, E., Tharreau, D., Terauchi, R., & Kroj, T.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-04-01
- Volume
- 25
- Issue
- 4
- Pages
- 1463-1481
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2110768663
- Cited by
- 559
- References
- 70
- FWCI
- 40.39
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Cesari, S., Thilliez, G., Ribot, C., Chalvon, V., Michel, C., Jauneau, A., Rivas, S., Alaux, L., Kanzaki, H., Okuyama, Y., Morel, J.-B., Fournier, E., Tharreau, D., Terauchi, R., & Kroj, T. (2013). The Rice Resistance Protein Pair RGA4/RGA5 Recognizes the Magnaporthe oryzae Effectors AVR-Pia and AVR1-CO39 by Direct Binding. The Plant Cell. https://doi.org/10.1105/tpc.112.107201
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