The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
A DEAD Box RNA Helicase Is Critical for Pre-mRNA Splicing, Cold-Responsive Gene Regulation, and Cold Tolerance in Arabidopsis
Open accessAbstract
Cold stress resulting from chilling and freezing temperatures substantially reduces crop production worldwide. To identify genes critical for cold tolerance in plants, we screened Arabidopsis thaliana mutants for deregulated expression of a firefly luciferase reporter gene under the control of the C-REPEAT BINDING FACTOR2 (CBF2) promoter (CBF2:LUC). A regulator of CBF gene expression1 (rcf1-1) mutant that is hypersensitive to cold stress was chosen for in-depth characterization. RCF1 encodes a cold-inducible DEAD (Asp-Glu-Ala-Asp) box RNA helicase. Unlike a previously reported DEAD box RNA helicase (LOW EXPRESSION OF OSMOTICALLY RESPONSIVE GENES4 [LOS4]) that regulates mRNA export, RCF1 does not play a role in mRNA export. Instead, RCF1 functions to maintain proper splicing of pre-mRNAs; many cold-responsive genes are mis-spliced in rcf1-1 mutant plants under cold stress. Functional characterization of four genes (PSEUDO-RESPONSE REGULATOR5 [PRR5], SHAGGY-LIKE SERINE/THREONINE KINASE12 [SK12], MYB FAMILY TRANSCRIPTION FACTOR CIRCADIAN1 [CIR1], and SPFH/PHB DOMAIN-CONTAINING MEMBRANE-ASSOCIATED PROTEIN [SPFH]) that are mis-spliced in rcf1-1 revealed that these genes are cold-inducible positive (CIR1 and SPFH) and negative (PRR5 and SK12) regulators of cold-responsive genes and cold tolerance. Together, our results suggest that the cold-inducible RNA helicase RCF1 is essential for pre-mRNA splicing and is important for cold-responsive gene regulation and cold tolerance in plants.
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Cites
Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
Edgar, R. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.1.207 · Cited by 13,288
Liu, Q., Kasuga, M., Sakuma, Y., Abe, H., Miura, S., Yamaguchi-Shinozaki, K., & Shinozaki, K. (1998) · The Plant Cell · doi:10.1105/tpc.10.8.1391 · Cited by 3,044
Stockinger, E. J., Gilmour, S. J., & Thomashow, M. F. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.3.1035 · Cited by 1,807
Cited by
Molecular Regulation of Plant Responses to Environmental Temperatures
Ding, Y., Shi, Y., & Yang, S. (2020) · Molecular Plant · doi:10.1016/j.molp.2020.02.004 · Cited by 787
MYB transcription factors, active players in abiotic stress signaling
Li, C., Ng, C. K.-Y., & Fan, L.-M. (2015) · Environmental and Experimental Botany · doi:10.1016/j.envexpbot.2014.06.014 · Cited by 406
Surviving and thriving: How plants perceive and respond to temperature stress
Ding, Y., & Yang, S. (2022) · Developmental Cell · doi:10.1016/j.devcel.2022.03.010 · Cited by 396
Cold Signal Transduction and its Interplay with Phytohormones During Cold Acclimation
Shi, Y., Ding, Y., & Yang, S. (2015) · Plant and Cell Physiology · doi:10.1093/pcp/pcu115 · Cited by 344
Rapid and Dynamic Alternative Splicing Impacts the Arabidopsis Cold Response Transcriptome
Calixto, C. P. G., Guo, W., James, A. B., Tzioutziou, N. A., Entizne, J. C., Panter, P. E., Knight, H., Nimmo, H. G., Zhang, R., & Brown, J. W. S. (2018) · The Plant Cell · doi:10.1105/tpc.18.00177 · Cited by 298
Metadata
- Authors
- Guan, Q., Wu, J., Zhang, Y., Jiang, C., Liu, R., Chai, C., & Zhu, J.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-01-01
- Volume
- 25
- Issue
- 1
- Pages
- 342-356
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2109147807
- Cited by
- 188
- References
- 3
- FWCI
- 14.96
- Type
- journal article
- Language
- en
- Open access
- green
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- Guan, Q., Wu, J., Zhang, Y., Jiang, C., Liu, R., Chai, C., & Zhu, J. (2013). A DEAD Box RNA Helicase Is Critical for Pre-mRNA Splicing, Cold-Responsive Gene Regulation, and Cold Tolerance in Arabidopsis. The Plant Cell. https://doi.org/10.1105/tpc.112.108340
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