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Phosphorylation of an ERF Transcription Factor by Arabidopsis MPK3/MPK6 Regulates Plant Defense Gene Induction and Fungal Resistance
Open accessAbstract
Arabidopsis thaliana MPK3 and MPK6, two mitogen-activated protein kinases (MAPKs or MPKs), play critical roles in plant disease resistance by regulating multiple defense responses. Previously, we characterized the regulation of phytoalexin biosynthesis by Arabidopsis MPK3/MPK6 cascade and its downstream WRKY33 transcription factor. Here, we report another substrate of MPK3/MPK6, ETHYLENE RESPONSE FACTOR6 (ERF6), in regulating Arabidopsis defense gene expression and resistance to the necrotrophic fungal pathogen Botrytis cinerea. Phosphorylation of ERF6 by MPK3/MPK6 in either the gain-of-function transgenic plants or in response to B. cinerea infection increases ERF6 protein stability in vivo. Phospho-mimicking ERF6 is able to constitutively activate defense-related genes, especially those related to fungal resistance, including PDF1.1 and PDF1.2, and confers enhanced resistance to B. cinerea. By contrast, expression of ERF6-EAR, in which ERF6 was fused to the ERF-associated amphiphilic repression (EAR) motif, strongly suppresses B. cinerea–induced defense gene expression, leading to hypersusceptibility of the ERF6-EAR transgenic plants to B. cinerea. Different from ERF1, the regulation and function of ERF6 in defensin gene activation is independent of ethylene. Based on these data, we conclude that ERF6, another substrate of MPK3 and MPK6, plays important roles downstream of the MPK3/MPK6 cascade in regulating plant defense against fungal pathogens.
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Cites
Mapping and quantifying mammalian transcriptomes by RNA-Seq
Mortazavi, A., Williams, B. A., McCue, K., Schaeffer, L., & Wold, B. (2008) · Nature Methods · doi:10.1038/nmeth.1226 · Cited by 13,696
Jones, J. D. G., & Dangl, J. L. (2006) · Nature · doi:10.1038/nature05286 · Cited by 13,177
Cited by
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MAPK Cascades in Plant Disease Resistance Signaling
Meng, X., & Zhang, S. (2013) · Annual Review of Phytopathology · doi:10.1146/annurev-phyto-082712-102314 · Cited by 1,367
Self-citationSignaling Mechanisms in Pattern-Triggered Immunity (PTI)
Bigeard, J., Colcombet, J., & Hirt, H. (2015) · Molecular Plant · doi:10.1016/j.molp.2014.12.022 · Cited by 1,105
Ethylene Response Factors: A Key Regulatory Hub in Hormone and Stress Signaling
Müller, M., & Munné-Bosch, S. (2015) · Plant Physiology · doi:10.1104/pp.15.00677 · Cited by 729
Qi, J., Song, C., Wang, B., Zhou, J., Kangasjärvi, J., Zhu, J., & Gong, Z. (2018) · Journal of Integrative Plant Biology · doi:10.1111/jipb.12654 · Cited by 654
Metadata
- Authors
- Meng, X., Xu, J., He, Y., Yang, K.-Y., Mordorski, B., Liu, Y., & Zhang, S.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-03-01
- Volume
- 25
- Issue
- 3
- Pages
- 1126-1142
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2122685460
- Cited by
- 429
- References
- 2
- FWCI
- 37.77
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Meng, X., Xu, J., He, Y., Yang, K.-Y., Mordorski, B., Liu, Y., & Zhang, S. (2013). Phosphorylation of an ERF Transcription Factor by Arabidopsis MPK3/MPK6 Regulates Plant Defense Gene Induction and Fungal Resistance. The Plant Cell. https://doi.org/10.1105/tpc.112.109074
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