The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A Chaperone Function of NO CATALASE ACTIVITY1 Is Required to Maintain Catalase Activity and for Multiple Stress Responses in Arabidopsis
Open accessAbstract
Catalases are key regulators of reactive oxygen species homeostasis in plant cells. However, the regulation of catalase activity is not well understood. In this study, we isolated an Arabidopsis thaliana mutant, no catalase activity1-3 (nca1-3) that is hypersensitive to many abiotic stress treatments. The mutated gene was identified by map-based cloning as NCA1, which encodes a protein containing an N-terminal RING-finger domain and a C-terminal tetratricopeptide repeat-like helical domain. NCA1 interacts with and increases catalase activity maximally in a 240-kD complex in planta. In vitro, NCA1 interacts with CATALASE2 (CAT2) in a 1:1 molar ratio, and the NCA1 C terminus is essential for this interaction. CAT2 activity increased 10-fold in the presence of NCA1, and zinc ion binding of the NCA1 N terminus is required for this increase. NCA1 has chaperone protein activity that may maintain the folding of catalase in a functional state. NCA1 is a cytosol-located protein. Expression of NCA1 in the mitochondrion of the nca1-3 mutant does not rescue the abiotic stress phenotypes of the mutant, while expression in the cytosol or peroxisome does. Our results suggest that NCA1 is essential for catalase activity.
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Cites
Mannitol Protects against Oxidation by Hydroxyl Radicals
Shen, B., Jensen, R. G., & Bohnert, H. J. (1997) · Plant Physiology · doi:10.1104/pp.115.2.527 · Cited by 422
Werdan, K., Heldt, H. W., & Milovancev, M. (1975) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(75)90041-9 · Cited by 391
Cited by
Elucidating the molecular mechanisms mediating plant salt‐stress responses
Yang, Y., & Guo, Y. (2018) · New Phytologist · doi:10.1111/nph.14920 · Cited by 1,631
Self-citationHydrogen peroxide metabolism and functions in plants
Smirnoff, N., & Arnaud, D. (2019) · New Phytologist · doi:10.1111/nph.15488 · Cited by 985
Wang, P., Liu, W., Han, C., Wang, S., Bai, M., & Song, C. (2024) · Journal of Integrative Plant Biology · doi:10.1111/jipb.13601 · Cited by 559
Tian, Y., Fan, M., Qin, Z., Lv, H., Wang, M., Zhang, Z., Zhou, W., Zhao, N., Li, X., Han, C., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03463-x · Cited by 265
Peroxisomes: Versatile organelles with diverse roles in plants
Pan, R., Liu, J., Wang, S., & Hu, J. (2020) · New Phytologist · doi:10.1111/nph.16134 · Cited by 145
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Metadata
- Authors
- Li, J., Liu, J., Wang, G., Cha, J.-Y., Li, G., Chen, S., Li, Z., Guo, J., Zhang, C., Yang, Y., Kim, W.-Y., Yun, D.-J., Schumaker, K. S., Chen, Z., & Guo, Y.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-02-19
- Volume
- 27
- Issue
- 3
- Pages
- 908-925
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2172292127
- Cited by
- 173
- References
- 2
- FWCI
- 12.22
- Type
- journal article
- Language
- en
- Open access
- green
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- Li, J., Liu, J., Wang, G., Cha, J.-Y., Li, G., Chen, S., Li, Z., Guo, J., Zhang, C., Yang, Y., Kim, W.-Y., Yun, D.-J., Schumaker, K. S., Chen, Z., & Guo, Y. (2015). A Chaperone Function of NO CATALASE ACTIVITY1 Is Required to Maintain Catalase Activity and for Multiple Stress Responses in Arabidopsis. The Plant Cell. https://doi.org/10.1105/tpc.114.135095
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