The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
The Role of AHA Motifs in the Activator Function of Tomato Heat Stress Transcription Factors HsfA1 and HsfA2
Open accessAbstract
Using reporter assays in tobacco protoplasts and yeast, we investigated the function of the acidic C-terminal activation domains of tomato heat stress transcription factors HsfA1 and HsfA2. Both transcription factors contain short, essential peptide motifs with a characteristic pattern of aromatic and large hydrophobic amino acid residues embedded in an acidic context (AHA motifs). The prototype is the AHA1 motif of HsfA2, which has the sequence DDIWEELL. Our mutational analysis supports the important role of the aromatic and large hydrophobic amino acid residues in the core positions of the AHA motifs. The pattern suggests the formation of an amphipathic, negatively charged helix as the putative contact region with components of the basal transcription complex. In support of this concept, proline or positively charged residues in or adjacent to the AHA motifs markedly reduce or abolish their activity. Both AHA motifs of HsfA1 and HsfA2 contribute to activator potential, and they can substitute for each other; however, there is evidence for sequence and positional specificity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Structure of the MDM2 Oncoprotein Bound to the p53 Tumor Suppressor Transactivation Domain
Kussie, P. H., Gorina, S., Marechal, V., Elenbaas, B., Moreau, J., Levine, A. J., & Pavletich, N. P. (1996) · Science · doi:10.1126/science.274.5289.948 · Cited by 2,206
Heat Shock Transcription Factors: Structure and Regulation
Wu, C. (1995) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cb.11.110195.002301 · Cited by 1,231 · cited 1×
“…domain with heptad hydrophobic repeats (HR-A/B) involved in oligomerization, a cluster of basic amino acid residues essential for nuclear import (nuclear localization signal), and a C-terminal activation domain (CTAD; reviewed in Wu, 1995; Nover et al., 1996; Morimoto, 1998; Scharf et al., 1998a).”
BackgroundTranscriptional activation by recruitment
Ptashne, M., & Gann, A. (1997) · Nature · doi:10.1038/386569a0 · Cited by 1,158 · cited 1×
“According to the amino acid composition, activation domains are usually classified as acidic, glutamine rich, or proline rich (reviewed in Tjian and Maniatis, 1994; Triezenberg, 1995; Goodrich et al., 1996; Ptashne and Gann, 1997; Sauer and Tjian, 1997; Kadonaga, 1998).”
BackgroundSorger, P. K., & Pelham, H. R. B. (1988) · Cell · doi:10.1016/s0092-8674(88)91219-6 · Cited by 832
Radhakrishnan, I., Pérez-Alvarado, G. C., Parker, D., Dyson, H. J., Montminy, M. R., & Wright, P. E. (1997) · Cell · doi:10.1016/s0092-8674(00)80463-8 · Cited by 728
The enhanceosome and transcriptional synergy.
Carey, M. (1998) · Cell · doi:10.1016/s0092-8674(00)80893-4 · Cited by 553
Cited by
Nover, L., Bharti, K., Döring, P., Mishra, S. K., Ganguli, A., & Scharf, K.-D. (2001) · Cell Stress & Chaperones · doi:10.1379/1466-1268(2001)006<0177:aathst>2.0.co;2 · Cited by 769
Self-citationMishra, S. K., Tripp, J., Winkelhaus, S., Tschiersch, B., Theres, K., Nover, L., & Scharf, K.-D. (2002) · Genes & Development · doi:10.1101/gad.228802 · Cited by 603
Self-citationBaniwal, S. K., Bharti, K., Chan, K. Y., Fauth, M., Ganguli, A., Kotak, S., Mishra, S. K., Nover, L., Port, M., Scharf, K.-D., et al. (2004) · Journal of Biosciences · doi:10.1007/bf02712120 · Cited by 600
Self-citationSchramm, F., Larkindale, J., Kiehlmann, E., Ganguli, A., Englich, G., Vierling, E., & Von Koskull‐Döring, P. (2008) · The Plant Journal · doi:10.1111/j.1365-313x.2007.03334.x · Cited by 469
Sensitivity and Responses of Chloroplasts to Heat Stress in Plants
Hu, S., Ding, Y., & Zhu, C. (2020) · Frontiers in Plant Science · doi:10.3389/fpls.2020.00375 · Cited by 462
Metadata
- Authors
- Döring, P., Treuter, E., Kistner, C., Lyck, R., Chen, A., & Nover, L.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-02
- Volume
- 12
- Issue
- 2
- Pages
- 265-278
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2141616193
- Cited by
- 186
- References
- 6
- FWCI
- 1.35
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The Role of AHA Motifs in the Activator Function of Tomato Heat Stress Transcription Factors HsfA1 and HsfA2. https://app.cochat.ai/papers/10.1105/tpc.12.2.265
- The paper
- Döring, P., Treuter, E., Kistner, C., Lyck, R., Chen, A., & Nover, L. (2000). The Role of AHA Motifs in the Activator Function of Tomato Heat Stress Transcription Factors HsfA1 and HsfA2. The Plant Cell. https://doi.org/10.1105/tpc.12.2.265
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
