The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
The Thylakoid FtsH Protease Plays a Role in the Light-Induced Turnover of the Photosystem II D1 Protein
Open accessAbstract
The photosystem II reaction center D1 protein is known to turn over frequently. This protein is prone to irreversible damage caused by reactive oxygen species that are formed in the light; the damaged, nonfunctional D1 protein is degraded and replaced by a new copy. However, the proteases responsible for D1 protein degradation remain unknown. In this study, we investigate the possible role of the FtsH protease, an ATP-dependent zinc metalloprotease, during this process. The primary light-induced cleavage product of the D1 protein, a 23-kD fragment, was found to be degraded in isolated thylakoids in the dark during a process dependent on ATP hydrolysis and divalent metal ions, suggesting the involvement of FtsH. Purified FtsH degraded the 23-kD D1 fragment present in isolated photosystem II core complexes, as well as that in thylakoid membranes depleted of endogenous FtsH. In this study, we definitively identify the chloroplast protease acting on the D1 protein during its light-induced turnover. Unlike previously identified membrane-bound substrates for FtsH in bacteria and mitochondria, the 23-kD D1 fragment represents a novel class of FtsH substrate-functionally assembled proteins that have undergone irreversible photooxidative damage and cleavage.
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Cites
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Cited by
Recent advances in understanding the assembly and repair of photosystem II
Nixon, P. J., Michoux, F., Yu, J., Boehm, M., & Komenda, J. (2010) · Annals of Botany · doi:10.1093/aob/mcq059 · Cited by 565
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Plant proteases, protein degradation, and oxidative stress: role of peroxisomes
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Production of plant proteases in vivo and in vitro — A review
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Metadata
- Authors
- Lindahl, M., Spetea, C., Hundal, T., Oppenheim, A. B., Adam, Z., & Andersson, B.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-03
- Volume
- 12
- Issue
- 3
- Pages
- 419-431
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2155054459
- Cited by
- 395
- References
- 36
- FWCI
- 5.29
- Type
- journal article
- Language
- en
- Open access
- green
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- Lindahl, M., Spetea, C., Hundal, T., Oppenheim, A. B., Adam, Z., & Andersson, B. (2000). The Thylakoid FtsH Protease Plays a Role in the Light-Induced Turnover of the Photosystem II D1 Protein. The Plant Cell. https://doi.org/10.1105/tpc.12.3.419
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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