The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Type-B ARABIDOPSIS RESPONSE REGULATORs Specify the Shoot Stem Cell Niche by Dual Regulation of WUSCHEL
Open accessAbstract
Plants are known for their capacity to regenerate the whole body through de novo formation of apical meristems from a mass of proliferating cells named callus. Exogenous cytokinin and auxin determine cell fate for the establishment of the stem cell niche, which is the vital step of shoot regeneration, but the underlying mechanisms remain unclear. Here, we show that type-B ARABIDOPSIS RESPONSE REGULATORs (ARRs), critical components of cytokinin signaling, activate the transcription of WUSCHEL (WUS), which encodes a key regulator for maintaining stem cells. In parallel, type-B ARRs inhibit auxin accumulation by repressing the expression of YUCCAs, which encode a key enzyme for auxin biosynthesis, indirectly promoting WUS induction. Both pathways are essential for de novo regeneration of the shoot stem cell niche. In addition, the dual regulation of type-B ARRs on WUS transcription is required for the maintenance of the shoot apical meristem in planta. Thus, our results reveal a long-standing missing link between cytokinin signaling and WUS regulator, and the findings provide critical information for understanding cell fate specification.
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Citations
Cites
Signal integration in the control of shoot branching
Domagalska, M. A., & Leyser, O. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3088 · Cited by 835
The Stem Cell Niche in Leaf Axils Is Established by Auxin and Cytokinin in Arabidopsis
Wang, Y., Wang, J., Shi, B., Yu, T., Qi, J., Meyerowitz, E. M., & Jiao, Y. (2014) · The Plant Cell · doi:10.1105/tpc.114.123083 · Cited by 207
Shoot Meristem Formation in Vegetative Development.
Kerstetter, R. A., & Hake, S. (1997) · The Plant Cell · doi:10.1105/tpc.9.7.1001 · Cited by 171
Cited by
Cytokinin signaling in plant development
Kieber, J. J., & Schaller, G. E. (2018) · Development · doi:10.1242/dev.149344 · Cited by 758
New Insights Into Tissue Culture Plant-Regeneration Mechanisms
Long, Y., Yang, Y., Pan, G., & Shen, Y. (2022) · Frontiers in Plant Science · doi:10.3389/fpls.2022.926752 · Cited by 270
Metadata
- Authors
- Meng, W. J., Cheng, Z. J., Sang, Y. L., Zhang, M. M., Rong, X. F., Wang, Z. W., Tang, Y. Y., & Zhang, X. S.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-06
- Volume
- 29
- Issue
- 6
- Pages
- 1357-1372
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2620655516
- Cited by
- 340
- References
- 3
- FWCI
- 23.43
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- The paper
- Meng, W. J., Cheng, Z. J., Sang, Y. L., Zhang, M. M., Rong, X. F., Wang, Z. W., Tang, Y. Y., & Zhang, X. S. (2017). Type-B ARABIDOPSIS RESPONSE REGULATORs Specify the Shoot Stem Cell Niche by Dual Regulation of WUSCHEL. The Plant Cell. https://doi.org/10.1105/tpc.16.00640
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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