The DOI matches its Crossref record; 94 of the 95 references it cites were found in a registry or an index.
Monoterpenes Support Systemic Acquired Resistance within and between Plants
Open accessAbstract
This study investigates the role of volatile organic compounds in systemic acquired resistance (SAR), a salicylic acid (SA)-associated, broad-spectrum immune response in systemic, healthy tissues of locally infected plants. Gas chromatography coupled to mass spectrometry analyses of SAR-related emissions of wild-type and non-SAR-signal-producing mutant plants associated SAR with monoterpene emissions. Headspace exposure of Arabidopsis thaliana to a mixture of the bicyclic monoterpenes α-pinene and β-pinene induced defense, accumulation of reactive oxygen species, and expression of SA- and SAR-related genes, including the SAR regulatory AZELAIC ACID INDUCED1 (AZI1) gene and three of its paralogs. Pinene-induced resistance was dependent on SA biosynthesis and signaling and on AZI1. Arabidopsis geranylgeranyl reductase1 mutants with reduced monoterpene biosynthesis were SAR-defective but mounted normal local resistance and methyl salicylate-induced defense responses, suggesting that monoterpenes act in parallel with SA. The volatile emissions from SAR signal-emitting plants induced defense in neighboring plants, and this was associated with the presence of α-pinene, β-pinene, and camphene in the emissions of the “sender” plants. Our data suggest that monoterpenes, particularly pinenes, promote SAR, acting through ROS and AZI1, and likely function as infochemicals in plant-to-plant signaling, thus allowing defense signal propagation between neighboring plants.
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“In Arabidopsis, geranylgeranyl reductase1 mutants are defective in systemic acquired resistance against P. syringae (Riedlmeier et al., 2017).Adding the pathogen-induced volatiles aand b-pinene to the headspace of the mutant restores resistance, with the response depending on intact salicylic acid signaling and the AZELAIC ACID INDUCED (AZI1) gene (Riedlmeier et al., 2017).”
From Plant Secondary Metabolites as Defenses, Regulators, and Primary Metabolites: The Blurred Functional Trichotomy (2020) · cites this paper as Riedlmeier et al., 2017
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A leisurely look at the bootstrap, the jackknife, and cross-validation
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“A volatile compound was classified discriminant when both (1) importance in the projection was higher than 1 (VIP > 1) and (2) the uncertainty bar computed by jackknife method (Efron and Gong, 1983) was smaller than its respectiveVIPvalue.”
MethodSalicylic acid, a multifaceted hormone to combat disease
Vlot, A. C., Dempsey, D. A., & Klessig, D. F. (2009) · Annual Review of Phytopathology · doi:10.1146/annurev.phyto.050908.135202 · Cited by 2,568
Self-citationIsochorismate synthase is required to synthesize salicylic acid for plant defence
Wildermuth, M. C., Dewdney, J., Wu, G., & Ausubel, F. M. (2001) · Nature · doi:10.1038/35107108 · Cited by 2,333
Systemic Acquired Resistance: Turning Local Infection into Global Defense
Fu, Z. Q., & Dong, X. (2013) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-042811-105606 · Cited by 1,581
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Effector-Triggered Immunity: From Pathogen Perception to Robust Defense
Cui, H., Tsuda, K., & Parker, J. E. (2014) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-050213-040012 · Cited by 1,470
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Erb, M., & Kliebenstein, D. J. (2020) · Plant Physiology · doi:10.1104/pp.20.00433 · Cited by 1,333
Systemic Acquired Resistance and Salicylic Acid: Past, Present, and Future
Klessig, D. F., Choi, H. W., & Dempsey, D. A. (2018) · Molecular Plant-Microbe Interactions · doi:10.1094/mpmi-03-18-0067-cr · Cited by 554
Elnahal, A. S. M., El‐Saadony, M. T., Saad, A. M., Desoky, E. M., El-Tahan, A. M., Rady, M. M., AbuQamar, S. F., & El-Tarabily, K. A. (2022) · European Journal of Plant Pathology · doi:10.1007/s10658-021-02393-7 · Cited by 522
Systemic propagation of immunity in plants
Vlot, A. C., Sales, J. H., Lenk, M., Bauer, K., Brambilla, A., Sommer, A. K., Chen, Y., Wenig, M., & Nayem, S. (2020) · New Phytologist · doi:10.1111/nph.16953 · Cited by 486
Self-citationThe role of volatiles in plant communication
Bouwmeester, H. J., Schuurink, R. C., Bleeker, P., & Schiestl, F. P. (2019) · The Plant Journal · doi:10.1111/tpj.14496 · Cited by 393
Metadata
- Authors
- Riedlmeier, M., Ghirardo, A., Wenig, M., Knappe, C., Koch, K., Georgii, E., Dey, S., Parker, J. E., Schnitzler, J.-P., & Vlot, A. C.
- Affiliations
- Helmholtz Munich (DE)
- Max Planck Institute for Plant Breeding Research (DE)
- ORCID
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-05-23
- Volume
- 29
- Issue
- 6
- Pages
- 1440-1459
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- PMC
- PMC5502447
- OpenAlex
- W2619391819
- Cited by
- 323
- References
- 95
- Citations by year
- 2026: 32 · 2025: 49 · 2024: 44 · 2023: 38 · 2022: 39 · 2021: 46 · 2020: 30 · 2019: 19 · 2018: 23 · 2017: 2
- FWCI
- 19.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Plant Cell (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Max Planck Digital Library (submittedVersion)
- Site cant be reached (submittedVersion)
- PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (DFG) (SFB924)
- German federal ministry for education and research (DPPN 031A053C)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant-Microbe Interactions and Immunity
- Life Sciences › Agricultural and Biological Sciences › Insect Science › Insect-Plant Interactions and Control
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Keywords
- systemic acquired resistance, monoterpenes, α-pinene, β-pinene, camphor, volatile organic compounds, salicylic acid, reactive oxygen species, geranylgeranyl reductase, methyl salicylate, semiochemicals, Arabidopsis thaliana, plant defense
- MeSH terms
- Bicyclic Monoterpenes, Bridged Bicyclo Compounds, Immunity, Innate, Signal Transduction, Arabidopsis, Reactive Oxygen Species, Gene Expression Regulation, Plant, Salicylic Acid, Arabidopsis Proteins, Monoterpenes
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