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Sparse matrix sampling: a screening method for crystallization of proteins
Abstract
A set of screening conditions for initial experiments in protein crystallization has been developed, tested, and is herein presented. These solution and precipitant conditions are empirically derived based on known or published crystallization conditions of various proteins in the past, so as to sample as large a range of buffer, pH, additive and precipitant variables as possible, using small amounts of proteins. The 50 crystallization conditions have been tested on 15 previously crystallized proteins, all of which were also crystallized in at least one form by this screen. This method is also shown to be highly successful in the crystallization of proteins which had not previously been crystallized.
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Cited by
Crystal structure of opsin in its G-protein-interacting conformation
Scheerer, P., Park, J. H., Hildebrand, P. W., Kim, Y. J., Krauß, N., Choe, H.-W., Hofmann, K. P., & Ernst, O. P. (2008) · Nature · doi:10.1038/nature07330 · Cited by 1,059
Dyda, F., Hickman, A. B., Jenkins, T. M., Engelman, A., Craigie, R., & Davies, D. R. (1994) · Science · doi:10.1126/science.7801124 · Cited by 810
Activation mechanism of the MAP kinase ERK2 by dual phosphorylation
Canagarajah, B. J., Khokhlatchev, A., Cobb, M. H., & Goldsmith, E. J. (1997) · Cell · doi:10.1016/s0092-8674(00)80351-7 · Cited by 729
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Durbin, S. D., & Feher, G. (1996) · Annual Review of Physical Chemistry · doi:10.1146/annurev.physchem.47.1.171 · Cited by 303
Metadata
- Authors
- Jancarik, J., & Kim, S. H.
- Venue
- Journal of Applied Crystallography
- Published
- 1991-08-01
- Volume
- 24
- Issue
- 4
- Pages
- 409-411
- ISSN
- 0021-8898 (ISSN-L)
- OpenAlex
- W2060807817
- Cited by
- 2,049
- References
- 0
- FWCI
- 21.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- Jancarik, J., & Kim, S. H. (1991). Sparse matrix sampling: a screening method for crystallization of proteins. Journal of Applied Crystallography. https://doi.org/10.1107/s0021889891004430
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