CoChat
Sign Up
Cited by 192Neuroscience and Neural EngineeringNeural dynamics and brain functionNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Simultaneous measurement of intracellular calcium and electrical activity from patterned neural networks in culture

Jimbo, Y., Robinson, H.P.C., Kawana, A.·1993·IEEE Transactions on Biomedical Engineering
DOI 10.1109/10.238465
Open this paper in CoChat — free account

Abstract

Multisite extracellular electrical activity and intracellular calcium were recorded simultaneously. Electrical signals were measured using microelectrode array substrates. A novel cell positioning technique was combined with a method for controlling neurite outgrowth, which allowed cell-electrode contacts to be established easily, thus facilitating the electrical recording. Intracellular calcium was measured optically using the indicator fluo 3. Under low-magnesium conditions, cultured rat cortical neurons showed periodic transients of fluo-3 fluorescence, which were synchronized with the periodic bursting observed electrically. The intervals between bursts could be determined by electrical stimulation through the substrate electrodes. The results suggest that functional synaptic connections are formed in the culture system.

Overview

Integrity signals

Registry

Crossref · 10.1109/10.238465

Cites

0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Research works printed but not linked: 20

  1. 10.1109/IEMBS.1990.691994 · DOI
  2. 10.1242/jcs.1987.Supplement_8.4 · DOI
  3. 10.1016/0006-8993(88)91314-5 · DOI
  4. 10.1002/neu.480210110 · DOI
  5. 10.1002/jnr.490130115 · DOI
  6. kleinfeld, 1988, Controlled outgrowth of dissociated neurons on patterned substrates, J Neurosci, 8, 4098, 10.1523/JNEUROSCI.08-11-04098.1988 · DOI
  7. 10.1016/0165-3806(90)90265-Z · DOI
  8. 10.1016/0165-0270(85)90105-0 · DOI
  9. minta, 1989, Fluorescent indicators for cytosolic calcium based on rhodamine and fluorescein chromophores, J Biol Chem, 264, 8171, 10.1016/S0021-9258(18)83165-9 · DOI
  10. 10.1109/TBME.1979.326402 · DOI
  11. 10.1109/10.7273 · DOI
  12. 10.1016/0165-0270(88)90187-2 · DOI
  13. 10.1016/0165-0270(80)90042-4 · DOI
  14. 10.1109/10.102802 · DOI
  15. 10.1016/S0166-2236(84)80125-3 · DOI
  16. tsien, 1989, Methods in Cell Biology, 30, 127, 10.1016/S0091-679X(08)60978-4 · DOI
  17. 10.1016/0165-0270(89)90055-1 · DOI
  18. fromhcrz, 1991, A neuron-silicon junction: A retzius cell of the leech on an insulated-gate field-effect transistor, Science, 252, 1290, 10.1126/science.1925540 · DOI
  19. 10.2183/pjab.64.319 · DOI
  20. 10.1016/0304-3940(87)90563-5 · DOI

Cited by

Sorted by citations

See all 192

Metadata

Authors
Jimbo, Y., Robinson, H. P. C., & Kawana, A.
Affiliations
NTT (Japan) (JP)
ORCID
Venue
IEEE Transactions on Biomedical Engineering
Publisher
Institute of Electrical and Electronics Engineers (IEEE)
Published
1993
Volume
40
Issue
8
Pages
804-810
ISSN
0018-9294 (ISSN-L)
DOI
10.1109/10.238465
OpenAlex
W2051002031
Cited by
192
References
0
Citations by year
2025: 1 · 2024: 1 · 2023: 2 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 7 · 2015: 1 · 2014: 5 · 2013: 8 · 2012: 3
FWCI
1.43
Type
journal article
Language
en
Open access
closed
Licence
ieeexplore.ieee.org/Xplorehelp/downloads/license-information/IEEE.html (vor)
Locations
  • IEEE Transactions on Biomedical Engineering (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
intracellular calcium, microelectrode arrays, fluo-3, cortical neurons, neuronal bursting, electrical stimulation, cell positioning, synaptic connectivity, simultaneous recording
MeSH terms
Animals, Calcium, Cells, Cultured, Cerebral Cortex, Cytological Techniques, Electric Stimulation, Electrophysiology, Embryo, Mammalian, Equipment Design, Magnesium, Microelectrodes, Nerve Net, Neurons, Semiconductors, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review