The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Production of hydroxyapatite (HA) nanoparticle and HA/PCL tissue engineering scaffolds for bone tissue engineering
Abstract
Hydroxyapatite (HA) is biological apatite has close similarity of composition with human bone and teeth. Thus, it has been used in biomedical application in orthopedic and dentistry. The wet slurry of HA was successfully produced by mixing an acetone solution of calcium nitrate 4-hydrate with an aqueous solution of ammonium phosphate and ammonium carbonate with control pH of 11. The nano-emulsion was kept in freezer about one day and after that was kept in freeze drying machine about three days to obtain dry HA powder with low degree of agglomeration. The nanoparticles were studied under scanning electron microscopy (SEM). Energy Dispersive Xray (EDX) showed the spectrum of elements in HA with Ca/P ratio close to biological bone. The polycaprolactone (PCL) and hydroxyapatite/polycaprolactone (HA/PCL) composite scaffolds were produced using thermally induced phase separation (TIPS) technique. The scaffolds were studied under SEM and it was observed that both types of scaffolds had porous structures. The pore sizes of HA/PCL scaffold was slightly decreased compared to PCL scaffold. The HA nanoparticles were successfully produced and the PCL and HA/PCL scaffolds showed promises for bone tissue engineering application.
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“The pore size reduces in the presence of nano-HA [117]”
From Nano-hydroxyapatite/collagen composite as scaffold material for bone regeneration. (2023) · cites this paper as [117]
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Nano-hydroxyapatite/collagen composite as scaffold material for bone regeneration.
Kavitha Sri, A., Arthi, C., Neya, N. R., & Hikku, G. S. (2023) · Biomedical Materials · doi:10.1088/1748-605x/acc99e · Cited by 57
Metadata
- Authors
- Hassan, M. I., Mokhtar, M., Sultana, N., & Khan, T. H.
- Affiliations
- University of Technology Malaysia (MY)
- Venue
- 2012 IEEE-EMBS Conference on Biomedical Engineering and Sciences
- Publisher
- IEEE
- Published
- 2012-12
- Pages
- 239-242
- OpenAlex
- W2539154204
- Cited by
- 13
- References
- 26
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2015: 1 · 2014: 4
- FWCI
- 3.44
- Type
- conference paper
- Language
- en
- Open access
- closed
- Locations
- IEEE-EMBS Conference on Biomedical Engineering and Sciences (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Engineering › Mechanical Engineering › Surface Treatment and Coatings
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Keywords
- hydroxyapatite nanoparticles, polycaprolactone, bone tissue engineering, freeze-drying, thermally induced phase separation, porous scaffolds, pore size, calcium phosphate, nanoparticle agglomeration
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