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Cited by 21Diabetes Management and ResearchPancreatic function and diabetesControl Systems and Identification

Computational study of an augmented minimal model for glycaemia control

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Markakis, Mihalis G., Mitsis, Georgios D., Marmarelis, Vasilis Z.·2008·2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
DOI 10.1109/iembs.2008.4650446
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Abstract

In this paper we introduce a new model structure for the metabolic effects of intravenous insulin on blood glucose in man and derive its parameter values from the widely used model of Sorensen. The proposed model attempts to combine the advantages of the existing comprehensive and minimal models. Validation of the new model is done through deriving equivalent nonparametric nonlinear models in the form of Principal Dynamic Modes. We show that the new structure can represent the insulin-glucose dynamics of healthy subjects as well as Type 1 and Type 2 diabetics, with appropriate adjustment in its parameters.

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  • Historically, only the pharmacodynamics of glucagon have been included in comprehensive metabolism models.

    “Historically, only the pharmacodynamics of glucagon have been included in comprehensive metabolism models, such as Sorensen's model,11 revisions of the Sorensen model,12,13 and, more recently, the Padova meal model.14”

    From Pharmacokinetics Modeling of Exogenous Glucagon in Type 1 Diabetes Mellitus Patients (2013) · cites this paper as [12]

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Authors
Markakis, M. G., Mitsis, G. D., & Marmarelis, V. Z.
Affiliations
  • University of Southern California (US)
  • National Technical University of Athens (GR)
ORCID
Venue
2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Publisher
IEEE
Published
2008-08
Volume
2008
Pages
5445-5448
ISSN
2375-7477 (ISSN-L)
DOI
10.1109/iembs.2008.4650446
OpenAlex
W2164452776
Cited by
21
References
4
Citations by year
2026: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 1 · 2013: 4
FWCI
8.77
Type
conference paper
Language
en
Open access
Licence
other-oa
Locations
  • Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) (publishedVersion)
  • PubMed (publishedVersion)
  • DSpace - NTUA (National Technical University of Athens) (submittedVersion, other-oa)
Funders
National Institute of Biomedical Imaging and Bioengineering (P41EB001978)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Physical Sciences › Engineering › Control and Systems Engineering › Control Systems and Identification
Keywords
intravenous insulin, blood glucose dynamics, glucose-insulin dynamics, type 1 diabetes, type 2 diabetes
MeSH terms
Blood Glucose, Computer Simulation, Diabetes Mellitus, Type 2, Drug Therapy, Computer-Assisted, Humans, Hypoglycemic Agents, Injections, Intravenous, Insulin, Models, Biological

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