An Integrated Bidirectional Multi-Channel Opto-Electro Arbitrary Waveform Stimulator for Treating Motor Neurone Disease
Open accessAbstract
This paper presents a prototype integrated bidirectional stimulator ASIC capable of mixed opto-electro stimulation and electrophysiological signal recording. The development is part of the research into a fully implantable device for treating motor neurone disease using optogenetics and stem cell technology. The ASIC consists of 4 stimulator units, each featuring 16-channel optical and electrical stimulation using arbitrary current waveforms with an amplitude up to 16 mA and a frequency from 1.5 Hz to 50 kHz, and a recording front-end with a programmable bandwidth of 1 Hz to 4 kHz, and a programmable amplifier gain up to 74 dB. The ASIC was implemented in a 0.18μm CMOS technology. Simulated performance in stimulation and recording is presented.
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Biphasic delivery of stimulus pulses is commonly achieved using a set of switches placed in a H-bridge structure.
“Biphasic delivery of stimulus pulses is commonly achieved using a set of switches placed in a H-bridge structure. Each electrode operates as either a cathode or an anode from a single supply current, maximising flexibility and limiting the reliance on storage capacitors [57], [134].”
From Active Neural Interface Circuits and Systems for Selective Control of Peripheral Nerves: A Review (2024) · cites this paper as [134]
The Current Driver section (page unavailable) says the paper's H-bridge forms biphasic current pulses, supporting the described approach. It does not establish that this arrangement is commonly used across stimulators. (LLM, conf=0.82)
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References 18 · Cited by 11
- Authors
- Jiang, D., Wu, Y., Almarri, N., Habibollahi, M., Liu, F., Bryson, J. B., Greensmith, L., & Demosthenous, A.
- Affiliations
- University College London (GB)
- UCL Queen Square Institute of Neurology (GB)
- ORCID
- Venue
- 2021 IEEE International Symposium on Circuits and Systems (ISCAS)
- Publisher
- IEEE
- Published
- 2021-05
- Pages
- 1-4
- ISSN
- 0271-4302 (ISSN-L)
- OpenAlex
- W3159523312
- Cited by
- 11
- References
- 18
- Citations by year
- 2024: 2 · 2023: 3 · 2022: 3 · 2021: 3
- FWCI
- 11.06
- Type
- conference paper
- Language
- en
- Open access
- green
- discovery.ucl.ac.uk
- Licence
- Locations
- IEEE International Symposium on Circuits and Systems proceedings (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Biomedical Engineering › Analog and Mixed-Signal Circuit Design
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Radio Frequency Integrated Circuit Design
- Keywords
- optogenetics, motor neuron disease, multichannel stimulation, implantable neurostimulator, ASIC, electrophysiological recording, stem cell therapy, 0.18 μm CMOS
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