The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Simultaneous Molecular and Hypoxia Imaging of Brain Tumors In Vivo Using Spectroscopic Photoacoustic Tomography
Abstract
Noninvasive molecular and functional imaging in vivo is promising for detecting and monitoring various physiological conditions in animals and ultimately humans. To this end, we present a novel noninvasive technology, spectroscopic photoacoustic tomography (SPAT), which offers both strong optical absorption contrast and high ultrasonic spatial resolution. Optical contrast allows spectroscopic separation of signal contributions from multiple optical absorbers (e.g., oxyhemoglobin, deoxyhemoglobin, and a molecular contrast agent), thus enabling simultaneous molecular and functional imaging. SPAT successfully imaged with high resolution the distribution of a molecular contrast agent targeting integrin overexpressed in human U87 glioblastomas in nude mouse brains. Simultaneously, SPAT also imaged the hemoglobin oxygen saturation and the total hemoglobin concentration of the vasculature, which revealed hypoxia in tumor neovasculature. Therefore, SPAT can potentially lead to better understanding of the interrelationships between hemodynamics and specific biomarkers associated with tumor progression.
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Citations
Cites
Tumor Hypoxia: Definitions and Current Clinical, Biologic, and Molecular Aspects
Hockel, M., & Vaupel, P. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.4.266 · Cited by 2,662 · cited 1×
“Imaging of the oxygenation status of tumors, especially hypoxia, is receiving more and more attention in assessing tumor growth, malignant progression, metastasis, and resistance to various therapiesV including radiotherapy and chemotherapy as well as photodynamic therapy [23]–[ 27 ].”
BackgroundHypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis
Kaur, B., Khwaja, F. W., Severson, E. A., Matheny, S. L., Brat, D. J., & Van Meir, E. G. (2005) · Neuro-Oncology · doi:10.1215/s1152851704001115 · Cited by 725
Cited by
Going deeper than microscopy: the optical imaging frontier in biology
Ntziachristos, V. (2010) · Nature Methods · doi:10.1038/nmeth.1483 · Cited by 1,896
Yao, J., & Wang, L. V. (2013) · Laser & Photonics Reviews · doi:10.1002/lpor.201200060 · Cited by 616
Self-citationProspects of photoacoustic tomography
Wang, L. V. (2008) · Medical Physics · doi:10.1118/1.3013698 · Cited by 561
Self-citationIn Vivo Molecular Photoacoustic Tomography of Melanomas Targeted by Bioconjugated Gold Nanocages
Kim, C., Cho, E. C., Chen, J., Song, K. H., Au, L., Favazza, C., Zhang, Q., Cobley, C. M., Gao, F., Xia, Y., et al. (2010) · ACS Nano · doi:10.1021/nn100736c · Cited by 462
Self-citationWalsh, J. C., Lebedev, A., Aten, E., Madsen, K., Marciano, L., & Kolb, H. C. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5378 · Cited by 420
Metadata
- Authors
- Li, M.-L., Oh, J.-T., Xie, X., Ku, G., Wang, W., Li, C., Lungu, G., Stoica, G., & Wang, L. V.
- Venue
- Proceedings of the IEEE
- Published
- 2008-03
- Volume
- 96
- Issue
- 3
- Pages
- 481-489
- ISSN
- 0018-9219 (ISSN-L)
- 1558-2256
- OpenAlex
- W1995583204
- Cited by
- 352
- References
- 2
- FWCI
- 15.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Li, M.-L., Oh, J.-T., Xie, X., Ku, G., Wang, W., Li, C., Lungu, G., Stoica, G., & Wang, L. V. (2008). Simultaneous Molecular and Hypoxia Imaging of Brain Tumors In Vivo Using Spectroscopic Photoacoustic Tomography. Proceedings of the IEEE. https://doi.org/10.1109/jproc.2007.913515
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