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Algorithmic aspects of protein structure similarity

Goldman, D., Istrail, S., Papadimitriou, C.H.·2003·40th Annual Symposium on Foundations of Computer Science (Cat. No.99CB37039)

Abstract

We show that calculating contact map overlap (a measure of similarity of protein structures) is NP-hard, but can be solved in polynomial time for several interesting and relevant special cases. We identify an important special case of this problem corresponding to self-avoiding walks, and prove a decomposition theorem and a corollary approximation result for this special case. These are the first approximation algorithms with guaranteed error bounds, and NP-completeness results in the literature in the area of protein structure alignment/fold recognition for measures of structure similarity of practical interest.

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Metadata

Authors
Goldman, D., Istrail, S., & Papadimitriou, C. H.
Venue
40th Annual Symposium on Foundations of Computer Science (Cat. No.99CB37039)
Published
2003-01-20
Pages
512-521
ISSN
0272-5428 (ISSN-L)
OpenAlex
W1916412816
Cited by
172
References
3
FWCI
30.95
Type
conference paper
Language
en
Open access
closed

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CoChat. (2026). Citation check: Algorithmic aspects of protein structure similarity. https://app.cochat.ai/papers/10.1109/sffcs.1999.814624
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Goldman, D., Istrail, S., & Papadimitriou, C. H. (2003). Algorithmic aspects of protein structure similarity. 40th Annual Symposium on Foundations of Computer Science (Cat. No.99CB37039). https://doi.org/10.1109/sffcs.1999.814624

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