Flexible epineural strip electrode for recording in fine nerves
Abstract
This paper demonstrates flexible epineural strip electrodes (FLESE) for recording from small nerves. Small strip-shaped FLESE enables us to easily and closely stick on various sized nerves for less damage in a nerve and optimal recording quality. In addition, in order to enhance the neural interface, the gold electrode contacts were coated with carbon nanotubes, which reduced the impedance of the electrodes. We used the FLESEs to record electrically elicited nerve signals (compound neural action potentials) from the sciatic nerve in rats. Bipolar and differential bipolar configurations for the recording were investigated to optimize the recording configuration of the FLESEs. The successful results from differential bipolar recordings showed that the total length of FLESEs could be further reduced, maintaining the maximum recording ability, which would be beneficial for recording in very fine nerves. Our results demonstrate that new concept of FLESEs could play an important role in electroceuticals in near future.
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The flexible epineural strip electrode hook electrode showed good adhesion properties sufficient to implant without suturing during acute recording in a rat experiment.
“The hook electrode showed good adhesion properties sufficient to implant without suturing during acute recording in a rat experiment [48].”
From Interfaces with the peripheral nervous system for the control of a neuroprosthetic limb: a review (2020) · cites this paper as [48]
Previous studies of peripheral implants used for rodents have reported peak-to-peak signal amplitudes ranging from 100-900 μV in response to electrical stimuli.
“Previous studies of peripheral implants used for rodents have reported peak-to-peak signal amplitudes ranging from 100–900 μV in response to electrical stimuli [22–27].”
From A novel flexible cuff-like microelectrode for dual purpose, acute and chronic electrical interfacing with the mouse cervical vagus nerve (2017) · cites this paper as [25]
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References 41 · Cited by 33
- Authors
- Lee, S., Yen, S.-C., Sheshadri, S., Martinez, I. D., Xue, N., Xiang, Z., Thakor, N. V., & Lee, C.
- Affiliations
- National University of Singapore (SG)
- Agency for Science, Technology and Research (SG)
- Johns Hopkins University (US)
- Venue
- IEEE Transactions on Biomedical Engineering
- Published
- 2016-03
- Volume
- 63
- Issue
- 3
- Pages
- 581-587
- ISSN
- 0018-9294 (ISSN-L)
- 1558-2531
- OpenAlex
- W2288786162
- Cited by
- 33
- References
- 41
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 5 · 2019: 5 · 2018: 3 · 2017: 5 · 2016: 2
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- IEEE Transactions on Biomedical Engineering (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Research Foundation CRP Project (R-719-000-001-281)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Biomedical Engineering › Analog and Mixed-Signal Circuit Design
- Life Sciences › Neuroscience › Cognitive Neuroscience › Undergraduate Neuroscience Education and Research
- Keywords
- compound nerve action potential, sciatic nerve, neural interfaces, electroceuticals
- MeSH terms
- Animals, Electric Stimulation, Electrodes, Electrophysiology, Equipment Design, Female, Sciatic Nerve, Signal Processing, Computer-Assisted, Rats, Sprague-Dawley, Nanotubes, Carbon, Rats
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