Cited by 843Medical Image Segmentation TechniquesAdvanced Neural Network ApplicationsBrain Tumor Detection and Classification

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index; 1 of the 15 sources its claims cite were checked for support.

Interactive Medical Image Segmentation Using Deep Learning With Image-Specific Fine Tuning

Open access
Wang, Guotai, Li, Wenqi, Zuluaga, Maria A., Pratt, Rosalind, Patel, Premal A., Aertsen, Michael, Doel, Tom, David, Anna L., Deprest, Jan, Ourselin, Sebastien, Vercauteren, Tom·2018·IEEE Transactions on Medical Imaging

Abstract

Convolutional neural networks (CNNs) have achieved state-of-the-art performance for automatic medical image segmentation. However, they have not demonstrated sufficiently accurate and robust results for clinical use. In addition, they are limited by the lack of image-specific adaptation and the lack of generalizability to previously unseen object classes (a.k.a. zero-shot learning). To address these problems, we propose a novel deep learning-based interactive segmentation framework by incorporating CNNs into a bounding box and scribble-based segmentation pipeline. We propose image-specific fine tuning to make a CNN model adaptive to a specific test image, which can be either unsupervised (without additional user interactions) or supervised (with additional scribbles). We also propose a weighted loss function considering network and interaction-based uncertainty for the fine tuning. We applied this framework to two applications: 2-D segmentation of multiple organs from fetal magnetic resonance (MR) slices, where only two types of these organs were annotated for training and 3-D segmentation of brain tumor core (excluding edema) and whole brain tumor (including edema) from different MR sequences, where only the tumor core in one MR sequence was annotated for training. Experimental results show that: 1) our model is more robust to segment previously unseen objects than state-of-the-art CNNs; 2) image-specific fine tuning with the proposed weighted loss function significantly improves segmentation accuracy; and 3) our method leads to accurate results with fewer user interactions and less user time than traditional interactive segmentation methods.

Overview

Integrity signals

Registry

Crossref · 10.1109/tmi.2018.2791721

Cites

43 of 43 references verified0 citation errors · 0 not checkable

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Nothing to recompute.

Verification

Claims the paper makes

40 Own result · 26 Own interpretation · 9 Own method · 7 Not checked yet · 7 No basis given · 5 Sources not found · 1 Supported

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Show all 48 claims

  • It may state two separate claims as one. 39
  • Probably not a substantial claim. 13
47 of 47
  • The paper relies on this without support.

    Interactive segmentation remains the state of the art for existing commercial surgical planning and navigation products.

    “As such, interactive segmentation remains the state of the art for existing commercial surgical planning and navigation products.”
  • The paper relies on this without support.

    Current CNNs do not generalize well to previously unseen object classes that are absent from the training set.

    “The first challenge of using CNNs for interactive segmentation is that current CNNs do not generalize well to previously unseen object classes that are not present in the training set.”
  • The paper relies on this without support.

    Current CNNs are not adaptive to different test images because their parameters are learned from training images and then fixed during testing.

    “but current CNNs are not adaptive to different test images, as parameters of the model are learned from training images and then fixed in the testing stage, without image-specific adaptation.”
  • The paper relies on this without support.

    Interactive segmentation often requires image-specific learning to handle large context variations among different images.

    “Second, interactive segmentation often requires image-specific learning to deal with large context variations among different images”
  • The paper relies on this without support.

    Annotations for medical images are often expensive to acquire.

    “For medical images, annotations are often expensive to acquire as both expertise and time are needed to produce accurate annotations.”
  • The paper relies on this without support.

    Transitioning from GMMs to CNNs for image-specific adaptation has not yet been demonstrated.

    “However, transitioning from simple GMMs to powerful but complex CNNs in this context has not yet been demonstrated.”
6 of 6

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Citations

Cites

Show all 42 references

Research works printed but not linked: 2

  1. sermanet, 2014, Overfeat Integrated Recognition Localization and Detection Using Convolutional Networks
  2. vezhnevets, 2005, GrowCut: Interactive multi-label ND image segmentation by cellular automata, Proc GraphiCon, 150

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Metadata

Authors
Wang, G., Li, W., Zuluaga, M. A., Pratt, R., Patel, P. A., Aertsen, M., Doel, T., David, A. L., Deprest, J., Ourselin, S., & Vercauteren, T.
Affiliations
  • Wellcome / EPSRC Centre for Interventional and Surgical Sciences (GB)
  • KU Leuven (BE)
Corresponding author
Wang, Guotai
Venue
IEEE Transactions on Medical Imaging
Published
2018-07
Volume
37
Issue
7
Pages
1562-1573
ISSN
  • 0278-0062 (ISSN-L)
  • 1558-254X
OpenAlex
W2763160469
Cited by
843
References
42
Citations by year
2026: 37 · 2025: 82 · 2024: 102 · 2023: 112 · 2022: 132 · 2021: 146 · 2020: 130 · 2019: 76 · 2018: 26
FWCI
47.27
Type
journal article
Language
en
Open access
Locations
  • IEEE Transactions on Medical Imaging (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • arXiv (Cornell University) (submittedVersion)
  • Lirias (submittedVersion, other-oa)
  • UCL Discovery (University College London) (submittedVersion)
  • Research Portal (King's College London) (submittedVersion, cc-by)
  • arXiv (Cornell University)
Funders
  • Wellcome Trust (WT101957, WT97914, HICF-T4-275)
  • Engineering and Physical Sciences Research Council (NS/A000027/1, EP/H046410/1, EP/J020990/1, EP/K005278, NS/A000050/1, 203145Z/16/Z)
  • Royal Society (RG160569)
  • University College London
  • Great Ormond Street Hospital Charity
  • Nvidia
  • Emerald, a GPU-accelerated High Performance Computer, made available by the Science and Engineering South Consortium operated in partnership with the STFC Rutherford-Appleton Laboratory
Topics
  • Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Medical Image Segmentation Techniques
  • Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Advanced Neural Network Applications
  • Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Brain Tumor Detection and Classification
Keywords
zero-shot learning, scribble-based segmentation, weighted loss function, uncertainty estimation, brain tumor segmentation, magnetic resonance imaging, convolutional neural networks
MeSH terms
Deep Learning, Brain, Brain Neoplasms, Female, Fetus, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Pregnancy, Prenatal Diagnosis

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