Cited by 11,931Medical Image Segmentation TechniquesAdvanced Neural Network ApplicationsBrain Tumor Detection and Classification

V-Net: Fully Convolutional Neural Networks for Volumetric Medical Image Segmentation

Open access
Milletari, Fausto, Navab, Nassir, Ahmadi, Seyed-Ahmad·2016·2016 Fourth International Conference on 3D Vision (3DV)

Abstract

Convolutional Neural Networks (CNNs) have been recently employed to solve problems from both the computer vision and medical image analysis fields. Despite their popularity, most approaches are only able to process 2D images while most medical data used in clinical practice consists of 3D volumes. In this work we propose an approach to 3D image segmentation based on a volumetric, fully convolutional, neural network. Our CNN is trained end-to-end on MRI volumes depicting prostate, and learns to predict segmentation for the whole volume at once. We introduce a novel objective function, that we optimise during training, based on Dice coefficient. In this way we can deal with situations where there is a strong imbalance between the number of foreground and background voxels. To cope with the limited number of annotated volumes available for training, we augment the data applying random non-linear transformations and histogram matching. We show in our experimental evaluation that our approach achieves good performances on challenging test data while requiring only a fraction of the processing time needed by other previous methods.

Integrity signals

Registry

Crossref · 10.1109/3dv.2016.79

Cites

20 of 20 references verified0 citation errors · 0 not checkable

Statistics

Nothing to recompute.

Claims the paper makes

0 of 7 cited sources checked · 0 supported · 0 flagged

  • Findingown data

    On the PROMISE 2012 test set, V-Net with a Dice-based loss achieved an average Hausdorff distance of 5.71 ± 1.20 mm.

    “V-Net + Dice-based loss 0.869 ± 0.033 | 5.71 ± 1.20 mm | 82.39”
    Quote in the paperSubstantial claim
  • Findingown data

    On the PROMISE 2012 test set, V-Net with a Dice-based loss achieved a challenge score of 82.39.

    “V-Net + Dice-based loss 0.869 ± 0.033 | 5.71 ± 1.20 mm | 82.39”
    Quote in the paperSubstantial claim
  • Findingown data

    On the PROMISE 2012 test set, V-Net with a multinomial logistic loss achieved a challenge score of 63.30.

    “V-Net + mult. logistic loss 0.739 ± 0.088 | 10.55 ± 5.38 mm | 63.30”
    Quote in the paperNot a substantial claim
  • Findingown data

    The innermost portion of the CNN already captures the content of the whole input volume.

    “We report in Table 1 the receptive fields of each network layer, showing the fact that the innermost portion of our CNN already captures the content of the whole input volume.”
    Quote in the paperSubstantial claim
  • Findingown data

    The Dice-based loss produced better results than the same network trained with a multinomial logistic loss and sample re-weighting.

    “we obtain results that we experimentally observed are much better than the ones computed through the same network trained optimising a multinomial logistic loss with sample re-weighting”
    Quote in the paperSubstantial claim
  • May combine two claims. 6
  • Classified as probably not a substantial claim. 2
  • May combine two claims.

    Findingown data

    The approach achieves good performance on challenging test data while needing only a fraction of the processing time required by other previous methods.

    “We show in our experimental evaluation that our approach achieves good performances on challenging test data while requiring only a fraction of the processing time needed by other previous methods.”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Findingown data

    V-Net performs segmentation of MRI prostate volumes in a fast and accurate manner.

    “We presented and approach based on a volumetric convolutional neural network that performs segmentation of MRI prostate volumes in a fast and accurate manner.”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Findingnone given

    The CNN is trained end-to-end on prostate MRI volumes and predicts segmentation for the entire volume at once.

    “Our CNN is trained end-to-end on MRI volumes depicting prostate, and learns to predict segmentation for the whole volume at once.”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Findingown data

    The architecture, inspired by U-Net but divided into stages that learn residuals, improves both results and convergence time.

    “Although we inspired our architecture to the one proposed in [14], we divided it into stages that learn residuals and, as empirically observed, improve both results and convergence time.”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites [14]

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Study design and conductnone given

    The results reported in the paper were obtained directly from the challenge organisers after the authors submitted their segmentations.

    “All the results reported in this section of the paper were obtained directly from the organisers of the challenge after submitting the segmentation obtained through our approach.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Premisecitation

    Shallower layers capture local information while deeper layers capture global information.

    “Shallower layers grasp local information while deeper layers use filters whose receptive fields are much broader that therefore capture global information [19].”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [19]

      Not checked in the free run.

  • May combine two claims.

    Interpretationreasoning

    The deepest layer's features perceive the whole anatomy at once and impose global constraints, which is important for segmenting poorly visible anatomy.

    “We believe that this characteristic is important during segmentation of poorly visible anatomy: the features computed in the deepest layer perceive the whole anatomy of interest at once, since they are computed from data having a spatial support much larger than the typical size of the anatomy we seek to delineate, and therefore impose global constraints.”
    Quote in the paperSubstantial claim
7 of 7
  • The paper relies on this without support.

    Annotated medical volumes are difficult to obtain because experts must manually trace reliable ground truth and there is a cost to acquiring them.

    “Annotated medical volumes are not easy to obtain due to the fact that one or more experts are required to manually trace a reliable ground truth annotation and that there is a cost associated with their acquisition.”
  • The paper relies on this without support.

    Patch-wise segmentation approaches are prone to failure because they use only local context, especially in challenging modalities such as ultrasound.

    “Such segmentations are obtained by only considering local context and therefore are prone to failure, especially in challenging modalities such as ultrasound, where a high number of mis-classified voxel are to be expected.”
2 of 2

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Milletrate et al. implemented a 3D CNN for segmenting MRI prostate images, attaining a 0.869 Dice coefficient score, the same as the winning teams in the PROMISE2012 competition.

    “Milletrate et al. [304] implemented 3D CNN for segmenting MRI prostate images. Furthermore, they used the PROMISE2012 challenge dataset, from which fifty MRI scans were used for training and thirty for testing. The U-Net architecture of Ronnerberger et al. [305] inspired their V-net. This model attained a 0.869 Dice coefficient score, the same as the winning teams in the competition.”

    From Review of deep learning: concepts, CNN architectures, challenges, applications, future directions (2021) · cites this paper as [304]

    The paper describes a volumetric CNN for prostate MRI segmentation and reports an average Dice coefficient of 0.869 for V-Net with Dice-based loss (Conclusion, Table 2). It also reports 50 PROMISE2012 training volumes and 30 test volumes. But Table 2 gives the leading comparison methods Dice coefficients of 0.879 and 0.874, not the same 0.869 score. (LLM, conf=0.88)

    Experimental — accuracy not yet measured
  • V-net was suggested as an extension of U-net for segmentation of the prostate on volumetric MRI images.

    “For example, V-net was suggested as an extension of U-net for segmentation of the prostate on volumetric MRI images [49].”
  • V-net utilized a loss function based on the Dice coefficient between segmentation results and ground truth, which directly reflected the quality of prostate segmentation.

    “In the study, V-net utilized a loss function based on the Dice coefficient between segmentation results and ground truth, which directly reflected the quality of prostate segmentation.”
  • We compared our nerve segmentation model with other advanced 3D image segmentation networks, training each on the same training dataset until full convergence.

    “We compared our nerve segmentation model with other advanced 3D image segmentation networks50 (Supplementary Table 1): VNet51, Attention U-Net52, nnFormer53, UNETR54, SwinUNETR55, nnU-Net56 and nnUNetRes56. Each network was trained on the same training dataset until full convergence, defined as no decrease in the training loss for ten consecutive epochs.”
  • We implemented comparison baselines (3D UNet, V-Net, Attention U-Net, nnFormer, UNETR) trained with the nnU-Net pipeline, and selected the finetuned VesselFM based on voxel Dice and instance Dice metrics from fivefold cross validation.

    “As comparison baselines, we implemented the following architectures: 3D UNet57, V-Net51, Attention U-Net52, nnFormer53 and UNETR54. All were trained by using the nnU-Net pipeline56, with a patch size of 128 × 128 × 128 voxels, channel-wise z-score normalization, learning rate decay and SGD optimizer. The baselines were trained until convergence for 1,000 epochs and initial learning rates of [0.000”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

Each contradiction between two passages listed here was confirmed by an independent check.

  • Table 1 names a different convolution kernel size

    Minor

    The table caption describes 3 × 3 × 3 convolutional layers, while the methods section says the convolutions in each stage use 5×5×5 kernels.

1 of 1

Cites

Flagged first, then by citations

Research works printed but not linked: 5

  1. porter, 2003, Combining artificial neural networks and transrectal ultrasound in the diagnosis of prostate cancer, Oncology, 17, 1395
  2. sermanet, 2013, Overfeat Integrated Recognition Localization and Detection Using Convolutional Networks
  3. cicek, 2016, 3D U- Net Learning Dense Volumetric Segmentation from Sparse Annotation
  4. bernard, 2015, Standardized evaluation system for left ventricular segmentation algorithms in 3D echocardiography, Medical Imaging IEEE Transactions on
  5. vincent, 2012, Fully automatic segmentation of the prostate using active appearance models, MICCAI Grand Challenge PROMISE 2012

Cited by

Sorted by citations

Authors
Milletari, F., Navab, N., & Ahmadi, S.-A.
Affiliations
  • Technical University of Munich (DE)
  • Ludwig-Maximilians-Universität München (DE)
Venue
2016 Fourth International Conference on 3D Vision (3DV)
Publisher
IEEE
Published
2016-10
Pages
565-571
OpenAlex
W2432481613
Cited by
11,931
References
20
Citations by year
2026: 1261 · 2025: 1816 · 2024: 1880 · 2023: 1646 · 2022: 1541 · 2021: 1442 · 2020: 1071 · 2019: 812 · 2018: 348 · 2017: 98 · 2016: 7 · 2015: 1 · 2012: 3
FWCI
146.48
Type
conference paper
Language
en
Open access
Locations
  • International Conference on 3D Vision (3DV) (publishedVersion)
  • arXiv (Cornell University) (submittedVersion)
  • arXiv (Cornell University)
  • TIB Data Manager
Funders
Nvidia (K40 GPU)
Topics
  • Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Medical Image Segmentation Techniques
  • Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Advanced Neural Network Applications
  • Life Sciences › Neuroscience › Neurology › Brain Tumor Detection and Classification
Keywords
3D medical image segmentation, fully convolutional network, prostate MRI segmentation, class imbalance, data augmentation, histogram matching, end-to-end learning

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