The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Deep Neural Networks Improve Radiologists’ Performance in Breast Cancer Screening
Open accessAbstract
We present a deep convolutional neural network for breast cancer screening exam classification, trained, and evaluated on over 200000 exams (over 1000000 images). Our network achieves an AUC of 0.895 in predicting the presence of cancer in the breast, when tested on the screening population. We attribute the high accuracy to a few technical advances. 1) Our network's novel two-stage architecture and training procedure, which allows us to use a high-capacity patch-level network to learn from pixel-level labels alongside a network learning from macroscopic breast-level labels. 2) A custom ResNet-based network used as a building block of our model, whose balance of depth and width is optimized for high-resolution medical images. 3) Pretraining the network on screening BI-RADS classification, a related task with more noisy labels. 4) Combining multiple input views in an optimal way among a number of possible choices. To validate our model, we conducted a reader study with 14 readers, each reading 720 screening mammogram exams, and show that our model is as accurate as experienced radiologists when presented with the same data. We also show that a hybrid model, averaging the probability of malignancy predicted by a radiologist with a prediction of our neural network, is more accurate than either of the two separately. To further understand our results, we conduct a thorough analysis of our network's performance on different subpopulations of the screening population, the model's design, training procedure, errors, and properties of its internal representations. Our best models are publicly available at https://github.com/nyukat/breast_cancer_classifier.
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International evaluation of an AI system for breast cancer screening
McKinney, S. M., Sieniek, M., Godbole, V., Godwin, J., Antropova, N., Ashrafian, H., Back, T., Chesus, M., Corrado, G. S., Darzi, A., et al. (2020) · Nature · doi:10.1038/s41586-019-1799-6 · Cited by 3,287
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Key challenges for delivering clinical impact with artificial intelligence
Kelly, C. J., Karthikesalingam, A., Suleyman, M., Corrado, G., & King, D. (2019) · BMC Medicine · doi:10.1186/s12916-019-1426-2 · Cited by 3,136
Diagnostic accuracy of deep learning in medical imaging: a systematic review and meta-analysis
Aggarwal, R., Sounderajah, V., Martin, G., Ting, D. S. W., Karthikesalingam, A., King, D., Ashrafian, H., & Darzi, A. (2021) · npj Digital Medicine · doi:10.1038/s41746-021-00438-z · Cited by 946
Predicting cancer outcomes with radiomics and artificial intelligence in radiology
Bera, K., Braman, N., Gupta, A., Velcheti, V., & Madabhushi, A. (2022) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-021-00560-7 · Cited by 819
Metadata
- Authors
- Wu, N., Phang, J., Park, J., Shen, Y., Huang, Z., Zorin, M., Jastrzebski, S., Fevry, T., Katsnelson, J., Kim, E., Wolfson, S., Parikh, U., Gaddam, S., Lin, L. L. Y., Ho, K., Weinstein, J. D., Reig, B., Gao, Y., Toth, H., Pysarenko, K., Lewin, A., Lee, J., Airola, K., Mema, E., Chung, S., Hwang, E., Samreen, N., Kim, S. G., Heacock, L., Moy, L., Cho, K., & Geras, K. J.
- Venue
- IEEE Transactions on Medical Imaging
- Published
- 2020-04
- Volume
- 39
- Issue
- 4
- Pages
- 1184-1194
- ISSN
- 0278-0062 (ISSN-L)
- 1558-254X
- OpenAlex
- W2980030301
- Cited by
- 689
- References
- 37
- FWCI
- 34.65
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Wu, N., Phang, J., Park, J., Shen, Y., Huang, Z., Zorin, M., Jastrzebski, S., Fevry, T., Katsnelson, J., Kim, E., Wolfson, S., Parikh, U., Gaddam, S., Lin, L. L. Y., Ho, K., Weinstein, J. D., Reig, B., Gao, Y., Toth, H., . . . Geras, K. J. (2020). Deep Neural Networks Improve Radiologists’ Performance in Breast Cancer Screening. IEEE Transactions on Medical Imaging. https://doi.org/10.1109/tmi.2019.2945514
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