The DOI matches its Crossref record; 29 of the 30 references it cites were found in a registry or an index.
Reliability of signals from a chronically implanted, silicon-based electrode array in non-human primate primary motor cortex
Abstract
Multiple-electrode arrays are valuable both as a research tool and as a sensor for neuromotor prosthetic devices, which could potentially restore voluntary motion and functional independence to paralyzed humans. Long-term array reliability is an important requirement for these applications. Here, we demonstrate the reliability of a regular array of 100 microelectrodes to obtain neural recordings from primary motor cortex (MI) of monkeys for at least three months and up to 1.5 years. We implanted Bionic (Cyberkinetics, Inc., Foxboro, MA) silicon probe arrays in MI of three Macaque monkeys. Neural signals were recorded during performance of an eight-direction, push-button task. Recording reliability was evaluated for 18, 35, or 51 sessions distributed over 83, 179, and 569 days after implantation, respectively, using qualitative and quantitative measures. A four-point signal quality scale was defined based on the waveform amplitude relative to noise. A single observer applied this scale to score signal quality for each electrode. A mean of 120 (+/- 17.6 SD), 146 (+/- 7.3), and 119 (+/- 16.9) neural-like waveforms were observed from 65-85 electrodes across subjects for all recording sessions of which over 80% were of high quality. Quantitative measures demonstrated that waveforms had signal-to-noise ratio (SNR) up to 20 with maximum peak-to-peak amplitude of over 1200 microv with a mean SNR of 4.8 for signals ranked as high quality. Mean signal quality did not change over the duration of the evaluation period (slope 0.001, 0.0068 and 0.03; NS). By contrast, neural waveform shape varied between, but not within days in all animals, suggesting a shifting population of recorded neurons over time. Arm-movement related modulation was common and 66% of all recorded neurons were tuned to reach direction. The ability for the array to record neural signals from parietal cortex was also established. These results demonstrate that neural recordings that can provide movement related signals for neural prostheses, as well as for fundamental research applications, can be reliably obtained for long time periods using a monolithic microelectrode array in primate MI and potentially from other cortical areas as well.
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“In fact, after appropriate control in experimental models to test their biocompatibility and efficacy [18], LIFEs have been recently used to control artificial devices [6,7,22-25] showing good results during short-term trials with human amputees.”
From Decoding of grasping information from neural signals recorded using peripheral intrafascicular interfaces (2011) · cites this paper as [22]
In the citing paper
“These trials showed that subjects are able to control a one-degree of freedom hand prosthesis through online processing of the efferent neural signals, and that repeatable sensory feedback may be received by stimulating afferent fibers [22,23] corresponding to the missing hand/fingers territories.”
From Decoding of grasping information from neural signals recorded using peripheral intrafascicular interfaces (2011) · cites this paper as [22]
Citations
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Learning to control a brain–machine interface for reaching and grasping by primates
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Serruya, M. D., Hatsopoulos, N. G., Paninski, L., Fellows, M. R., & Donoghue, J. P. (2002) · Nature · doi:10.1038/416141a · Cited by 1,415
Self-citationBrain responses to micro-machined silicon devices
Szarowski, D. H., Andersen, M. D., Retterer, S. T., Spence, A. J., Isaacson, M. S., Craighead, H. G., Turner, J. N., & Shain, W. G. (2003) · Brain Research · doi:10.1016/s0006-8993(03)03023-3 · Cited by 811
Chronic, multisite, multielectrode recordings in macaque monkeys
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Cerebral Astrocyte Response to Micromachined Silicon Implants
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Fabrication and biocompatibility of polypyrrole implants suitable for neural prosthetics.
George, P. M., Lyckman, A., Laván, D., Hegde, A., Leung, Y., Avasare, R., Testa, C., Alexander, P. M., Langer, R., & Sur, M. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2004.09.037 · Cited by 560
Research works printed but not linked: 1
- Horch, 2002, World Scientific
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Neuronal ensemble control of prosthetic devices by a human with tetraplegia
Hochberg, L. R., Serruya, M. D., Friehs, G. M., Mukand, J. A., Saleh, M., Caplan, A. H., Branner, A., Chen, D., Penn, R. D., & Donoghue, J. P. (2006) · Nature · doi:10.1038/nature04970 · Cited by 3,295
Self-citationReach and grasp by people with tetraplegia using a neurally controlled robotic arm
Hochberg, L. R., Bacher, D., Jarosiewicz, B., Masse, N. Y., Simeral, J. D., Vogel, J., Haddadin, S., Liu, J., Cash, S. S., van der Smagt, P., et al. (2012) · Nature · doi:10.1038/nature11076 · Cited by 2,719
Self-citationNeural Stimulation and Recording Electrodes
Cogan, S. F. (2008) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.10.061807.160518 · Cited by 2,243
Microneedles for drug and vaccine delivery
Kim, Y., Park, J., & Prausnitz, M. R. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.04.005 · Cited by 1,776
Brain-Controlled Interfaces: Movement Restoration with Neural Prosthetics
Schwartz, A. B., Cui, X. T., Weber, D. J., & Moran, D. W. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.019 · Cited by 792
Metadata
- Authors
- Suner, S., Fellows, M. R., Vargas-Irwin, C., Nakata, G. K., & Donoghue, J. P.
- Affiliations
- Brown University (US)
- Venue
- IEEE Transactions on Neural Systems and Rehabilitation Engineering
- Published
- 2005-12
- Volume
- 13
- Issue
- 4
- Pages
- 524-541
- ISSN
- 1534-4320 (ISSN-L)
- 1558-0210
- OpenAlex
- W2113853842
- Cited by
- 415
- References
- 30
- Citations by year
- 2026: 6 · 2025: 17 · 2024: 12 · 2023: 13 · 2022: 13 · 2021: 25 · 2020: 10 · 2019: 15 · 2018: 25 · 2017: 23 · 2016: 19 · 2015: 28 · 2014: 36 · 2013: 26 · 2012: 16
- FWCI
- 6.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- IEEE Transactions on Neural Systems and Rehabilitation Engineering (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS-25074)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Neuroscience › Cognitive Neuroscience › EEG and Brain-Computer Interfaces
- Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
- Keywords
- chronic neural recording, primary motor cortex, non-human primates, macaque, signal-to-noise ratio, neuroprosthetics, parietal cortex, long-term implantation
- MeSH terms
- Action Potentials, Animals, Electrodes, Implanted, Electroencephalography, Equipment Design, Female, Humans, Macaca mulatta, Male, Microelectrodes, Motor Cortex, Primates, Sensitivity and Specificity, Silicon, Reproducibility of Results, Evoked Potentials, Motor, Equipment Failure Analysis
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