Retinal Neurostimulator for a Multifocal Vision Prosthesis
Abstract
A neurostimulator application-specific integrated circuit (ASIC) with scalable circuitry that can stimulate 14 channels, has been developed for an epi-retinal vision prosthesis. This ASIC was designed to allow seven identical units to be connected to control up to 98 channels, with the ability to stimulate 14 electrodes simultaneously. The neurostimulator forms part of a vision prosthesis, designed to restore vision to patients who have lost their sight due to retinal diseases such as retinitis pigmentosa and macular degeneration. For charge balance, the neurostimulator was designed to stimulate with current sources and sinks operating together, and with the ability to drive a hexagonal mosaic of electrodes to reduce the electrical crosstalk that occurs when multiple bipolar stimulation sites are active simultaneously. A hexagonal mosaic of electrodes surrounds each stimulation site and has been shown to effectively isolate each site, increasing the ability to inject localized independent charge into multiple regions simultaneously.
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Epi-retinal interfaces have incorporated a hexagonal mosaic of guard electrodes to reduce crosstalk on a stimulator IC using a push-pull topology.
“Epi-retinal interfaces have incorporated a hexagonal mosaic of guard electrodes to reduce crosstalk on a stimulator IC using a push-pull topology [149].”
From Active Neural Interface Circuits and Systems for Selective Control of Peripheral Nerves: A Review (2024) · cites this paper as [149]
Localized stimulation returns the stimulation current to a local ground.
“Another artifact suppressing technique reported is the localized stimulation (Wong et al., 2007; Yung-Chan et al., 2009), as shown in Figure 4G, where the stimulation current returns to a local ground.”
From Advances in Neural Recording and Stimulation Integrated Circuits (2021) · cites this paper as Wong et al., 2007
Localized stimulation reduces the artifact amplitude at the input of the recording amplifier and allows the amplifier to quickly recover to the normal state, but the artifact is still not effectively suppressed.
“Although this reduces the artifact amplitude at the input of the recording amplifier and allows the amplifier to quickly recover to the normal state, the artifact is still not effectively suppressed.”
From Advances in Neural Recording and Stimulation Integrated Circuits (2021) · cites this paper as Wong et al., 2007
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References 28 · Cited by 79
- Authors
- Wong, Y. T., Dommel, N., Preston, P., Hallum, L. E., Lehmann, T., Lovell, N. H., & Suaning, G. J.
- Affiliations
- UNSW Sydney (AU)
- Venue
- IEEE Transactions on Neural Systems and Rehabilitation Engineering
- Published
- 2007-09
- Volume
- 15
- Issue
- 3
- Pages
- 425-434
- ISSN
- 1534-4320 (ISSN-L)
- 1558-0210
- OpenAlex
- W2096476047
- Cited by
- 79
- References
- 28
- Citations by year
- 2024: 1 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 2 · 2018: 3 · 2017: 6 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 4 · 2012: 9
- FWCI
- 3.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- IEEE Transactions on Neural Systems and Rehabilitation Engineering (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Biomedical Engineering › Analog and Mixed-Signal Circuit Design
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Keywords
- retinal prosthesis, nerve stimulator, application-specific integrated circuits, retinitis pigmentosa, macular degeneration, electrical crosstalk, charge balance
- MeSH terms
- Electrodes, Implanted, Electric Stimulation Therapy, Equipment Design, Humans, Retinal Diseases, Sensory Aids, Signal Processing, Computer-Assisted, Therapy, Computer-Assisted, Vision Disorders, Equipment Failure Analysis, Prostheses and Implants
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