On the Use of Longitudinal Intrafascicular Peripheral Interfaces for the Control of Cybernetic Hand Prostheses in Amputees
Abstract
Significant strides have been recently made to develop highly sensorized cybernetic prostheses aimed at restoring sensorimotor limb functions to those who have lost them because of a traumatic event (amputation). In these cases, one of the main goals is to create a bidirectional link between the artificial devices (e.g., robotic hands, arms, or legs) and the nervous system. Several human-machine interfaces (HMIs) are currently used to this aim. Among them, interfaces with the peripheral nervous system and in particular longitudinal intrafascicular electrodes can be a promising solution able to improve the current situation. In this paper, the potentials and limits of the use of this interface to control robotic devices are presented. Specific information is provided on: 1) the neurophysiological bases for the use peripheral nerve interfaces; 2) a comparison of the potentials of the different peripheral neural interfaces; 3) the possibility of extracting and appropriately interpreting the neural code for motor commands and of delivering sensory feedback by stimulating afferent fibers by using longitudinal intrafascicular electrodes; 4) a preliminary comparative analysis of the performance of this approach with the ones of others HMIs; 5) the open issues which have to be addressed for a chronic usability of this approach.
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To reproduce motor and sensory functions, a nerve interface must achieve topographical and functional selectivity.
“To adequately reproduce motor and sensory functions, it is necessary that the interface accomplish topographical selectivity and functional selectivity (Micera et al 2008).”
From Comparative analysis of transverse intrafascicular multichannel, longitudinal intrafascicular and multipolar cuff electrodes for the selective stimulation of nerve fascicles (2011) · cites this paper as Micera et al 2008
Longitudinal intra-fascicular electrodes can selectively stimulate nerve fibers, enabling activation of separate axonal subsets within a single fascicle and induction of graded responses.
“They are also able to selectively stimulate nerve fibers, even enabling the activation of separate axonal subsets within a single fascicle [88], and the induction of graded responses [89].”
From Interfaces with the peripheral nervous system for the control of a neuroprosthetic limb: a review (2020) · cites this paper as [88]
The first step toward a suitable reproduction of sensorimotor functionality is to determine the topographical location in the nerve for desired functions.
“Micera et al. (2008) suggested that the first step toward a suitable reproduction of sensorimotor functionality is to determine the topographical location in the nerve for desired functions.”
From Selectivity and Longevity of Peripheral-Nerve and Machine Interfaces: A Review. (2017) · cites this paper as Micera et al., 2008
An ideal closed-loop bidirectional prosthesis-user interface has mandatory components: peripheral-nerve data-recording electrodes; decoding of user intention; production of motor commands for the prosthesis system; passage of this information to the controller for controlling speed/force; sensors embedded in the bionic hand/arm; and a sensory subsystem to encode feedback to an amputee through a神经?
“According to several studies (Micera et al., 2008; Rossini et al., 2010; Raspopovic et al., 2014), an ideal closed-loop bidirectional prosthesis-user interface has the following mandatory components (see Figure 1 below): (i) peripheral-nerve data-recording electrodes; (ii) decoding of user intention; (iii) production of motor commands for the prosthesis system; (iv) passage of this information to”
From Selectivity and Longevity of Peripheral-Nerve and Machine Interfaces: A Review. (2017) · cites this paper as Micera et al., 2008
LIFE implants are effective for long-term recording and stimulation applications, having for example been used in humans for the recording of volitional limb movement and to elicit skin sensation of touch/pressure.
“LIFE implants are effective for long-term recording and stimulation applications, having for example been used in humans for the recording of volitional limb movement and to elicit skin sensation of touch/pressure (Dhillon et al., 2004, 2005; Micera et al., 2008).”
From Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics (2021) · cites this paper as Micera et al., 2008
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References 148 · Cited by 120
- Authors
- Micera, S., Navarro, X., Carpaneto, J., Citi, L., Tonet, O., Rossini, P. M., Carrozza, M. C., Hoffmann, K. P., Vivo, M., Yoshida, K., & Dario, P.
- Affiliations
- Scuola Superiore Sant'Anna (IT)
- Universitat Autònoma de Barcelona (ES)
- IMT School for Advanced Studies Lucca (IT)
- Università Campus Bio-Medico (IT)
- Fraunhofer Institute for Biomedical Engineering (DE)
- Aalborg University (DK)
- ORCID
- Venue
- IEEE Transactions on Neural Systems and Rehabilitation Engineering
- Published
- 2008-10
- Volume
- 16
- Issue
- 5
- Pages
- 453-472
- ISSN
- 1534-4320 (ISSN-L)
- 1558-0210
- OpenAlex
- W2138970539
- Cited by
- 120
- References
- 148
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 6 · 2022: 8 · 2021: 6 · 2020: 8 · 2019: 3 · 2018: 9 · 2017: 8 · 2016: 5 · 2015: 7 · 2014: 3 · 2013: 9 · 2012: 8
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- IEEE Transactions on Neural Systems and Rehabilitation Engineering (publishedVersion)
- PubMed (publishedVersion)
- BOA (University of Milano-Bicocca) (submittedVersion)
- Publikationsdatenbank der Fraunhofer-Gesellschaft (Fraunhofer-Gesellschaft) (submittedVersion)
- Fraunhofer-Publica (Fraunhofer-Gesellschaft) (submittedVersion)
- VBN Forskningsportal (Aalborg Universitet) (submittedVersion)
- Open Access at Essex (University of Essex) (submittedVersion)
- CINECA IRIS Institutional Research Information System (Sant'Anna School of Advanced Studies) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › EEG and Brain-Computer Interfaces
- Keywords
- peripheral nerve interfaces, amputees, robotic hand control, sensory feedback, afferent stimulation
- MeSH terms
- Amputees, Cybernetics, Electromyography, Equipment Design, Hand, Humans, Peripheral Nerves, Robotics, Equipment Failure Analysis, Prostheses and Implants
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