A multi-shank silk-backed parylene neural probe for reliable chronic recording
Abstract
Many chronic brain implants would benefit from a neural probe with many densely configured electrodes with stable recording quality. We present a novel strategy to scale up the number of electrodes with minimized risk of proportionally increasing the adverse foreign body reactions. A flexible parylene probe having 64 electrodes has been designed and fabricated with unique geometries for reduced tissue reactions. Biocompatible silk fibroin was patterned to provide a biodegradable mechanical support of the flexible probe during insertion. We validated the design with in vivo recording in rats and observed no significant deterioration in recording quality for over 5 weeks.
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Polytrodes: High-Density Silicon Electrode Arrays for Large-Scale Multiunit Recording
Blanche, T. J., Spacek, M. A., Hetke, J. F., & Swindale, N. V. (2005) · Journal of Neurophysiology · doi:10.1152/jn.01023.2004 · Cited by 282 · see citing works
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Soft Materials in Neuroengineering for Hard Problems in Neuroscience
Jeong, J.-W., Shin, G., Park, S. I., Yu, K. J., Xu, L., & Rogers, J. A. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.035 · Cited by 333 · see citing works
A review on mechanical considerations for chronically-implanted neural probes
Lecomte, A., Descamps, E., & Bergaud, C. (2018) · Journal of Neural Engineering · doi:10.1088/1741-2552/aa8b4f · Cited by 205 · see citing works
- Authors
- Wu, F., Tien, L., Chen, F., Kaplan, D., Berke, J., & Yoon, E.
- Affiliations
- University of Michigan (US)
- Tufts University (US)
- Venue
- 2013 Transducers & Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS & EUROSENSORS XXVII)
- Publisher
- IEEE
- Published
- 2013-06
- Pages
- 888-891
- ISSN
- 2167-0021 (ISSN-L)
- OpenAlex
- W2147545716
- Cited by
- 24
- References
- 1
- Citations by year
- 2024: 1 · 2023: 1 · 2021: 1 · 2020: 5 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 4
- FWCI
- 9.75
- Type
- conference paper
- Language
- en
- Open access
- closed
- Locations
- International Conference on Solid-State Sensors, Actuators and Microsystems (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Biomedical Engineering › Analog and Mixed-Signal Circuit Design
- Life Sciences › Neuroscience › Cognitive Neuroscience › Undergraduate Neuroscience Education and Research
- Keywords
- neural probes, parylene, silk fibroin, chronic neural recording, foreign body reaction, flexible probe, biocompatibility, in vivo recording
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