The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Itch and nerve fibers with special reference to atopic dermatitis: Therapeutic implications
Abstract
Nerve density in the epidermis is partly involved in itch sensitization in pruritic skin diseases, such as atopic dermatitis (AD). Epidermal innervation is thought to be regulated by the balance between nerve elongation factors (e.g. nerve growth factor) and nerve repulsion factors (e.g. semaphorin 3 A). Semaphorin 3 A (S ema3 A) has been shown to inhibit nerve growth factor (NGF)‐induced sprouting of sensory nerves, and epidermal S ema3 A levels are lower in AD patients, concomitant with an increase in epidermal nerve density. In addition, treatment with anti‐NGF, S ema3 A replacement, and several existing treatments, such as ultraviolet‐based therapies, normalized the hyperinnervation in AD, resulting in suppression of itching. This review expands knowledge regarding potential therapeutic strategies for ameliorating intractable pruritus in AD.
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Cites
Weisshaar, E., Apfelbacher, C., Jäger, G., Zimmermann, E., Bruckner, T., Diepgen, T. L., & Gollnick, H. (2006) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2006.07430.x · Cited by 167
Cited by
Weidinger, S., & Novak, N. (2016) · The Lancet · doi:10.1016/s0140-6736(15)00149-x · Cited by 1,908
Hidaka, T., Ogawa, E., Kobayashi, E. H., Suzuki, T., Funayama, R., Nagashima, T., Fujimura, T., Aiba, S., Nakayama, K., Okuyama, R., et al. (2017) · Nature Immunology · doi:10.1038/ni.3614 · Cited by 274
Peripheral itch sensitization in atopic dermatitis
Tominaga, M., & Takamori, K. (2022) · Allergology International · doi:10.1016/j.alit.2022.04.003 · Cited by 160
Self-citationBergeron, S., Reed, B. D., Wesselmann, U., & Bohm-Starke, N. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-020-0164-2 · Cited by 158
The pathology of type 2 inflammation-associated itch in atopic dermatitis
Moniaga, C. S., Tominaga, M., & Takamori, K. (2021) · Diagnostics · doi:10.3390/diagnostics11112090 · Cited by 28
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Metadata
- Authors
- Tominaga, M., & Takamori, K.
- Venue
- The Journal of Dermatology
- Publisher
- Wiley
- Published
- 2014-03
- Volume
- 41
- Issue
- 3
- Pages
- 205-212
- ISSN
- 0385-2407 (ISSN-L)
- 1346-8138
- OpenAlex
- W1979126820
- Cited by
- 197
- References
- 1
- FWCI
- 19.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Tominaga, M., & Takamori, K. (2014). Itch and nerve fibers with special reference to atopic dermatitis: Therapeutic implications. The Journal of Dermatology. https://doi.org/10.1111/1346-8138.12317
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
