Defective barrier function accompanied by structural changes of psoriatic stratum corneum
Abstract
Although barrier function of psoriatic skin is shown to be decreased by measuring transepidermal water loss (TEWL), few reports exist examining other physical skin properties and components including stratum corneum hydration, natural moisturizing factor (NMF), free fatty acids (FFA), β‐sheet and α‐helix ratio of structural protein(s), and sebum content. We compared the skin properties and components of normal, involved and uninvolved skin of psoriasis. Using a corneometer and attenuated total reflection‐infrared spectrometer, we measured TEWL, stratum corneum hydration, NMF, FFA, β/α ratio and sebum in psoriasis vulgaris patients and healthy controls. TEWL and β/α ratio of involved psoriatic skin were significantly increased compared with uninvolved skin and normal control skin. In contrast, stratum corneum hydration, NMF and FFA, but not sebum, are significantly decreased in the involved skin compared with uninvolved skin and normal skin. TEWL and stratum corneum hydration returned to the normal levels following clinical improvement of the lesion. Barrier function and hydration of psoriatic skin are defective and secondary structure in stratum corneum protein is altered in the involved psoriatic skin.
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Despite having sebaceous gland atrophy, the total amount of sebum production in psoriatic skin is not significantly changed.
“Despite having sebaceous gland atrophy, the total amount of sebum production in psoriatic skin is not significantly changed.35”
From Sebaceous-immunobiology is orchestrated by sebum lipids (2017) · cites this paper as [35]
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- Authors
- Takahashi, H., Tsuji, H., Minami‐Hori, M., Miyauchi, Y., & Iizuka, H.
- Affiliations
- Asahikawa Medical University (JP)
- Kao Corporation (Japan) (JP)
- Corresponding author
- Takahashi, Hidetoshi
- Venue
- The Journal of Dermatology
- Publisher
- Wiley
- Published
- 2014-01-29
- Volume
- 41
- Issue
- 2
- Pages
- 144-148
- ISSN
- 0385-2407 (ISSN-L)
- 1346-8138
- OpenAlex
- W2003442566
- Cited by
- 68
- References
- 27
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 11 · 2023: 5 · 2022: 8 · 2021: 8 · 2020: 5 · 2019: 2 · 2018: 9 · 2017: 5 · 2016: 7 · 2015: 2 · 2014: 1
- FWCI
- 2.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Keywords
- plaque psoriasis, skin barrier function, stratum corneum, transepidermal water loss, stratum corneum hydration, natural moisturizing factor, free fatty acids, sebum
- MeSH terms
- Adult, Aged, Epidermis, Fatty Acids, Nonesterified, Female, Humans, Male, Middle Aged, Psoriasis, Sebum, Water Loss, Insensible, Case-Control Studies, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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