IroT/mavN , a new iron‐regulated gene involved in L egionella pneumophila virulence against amoebae and macrophages
Open accessAbstract
Summary: L egionella pneumophila is a pathogenic bacterium commonly found in water. Eventually, it could be transmitted to humans via inhalation of contaminated aerosols. Iron is known as a key requirement for the growth of L . pneumophila in the environment and within its hosts. Many studies were performed to understand iron utilization by L . pneumophila but no global approaches were conducted. In this study, transcriptomic analyses were performed, comparing gene expression in L . pneumophila in standard versus iron restricted conditions. Among the regulated genes, a newly described one, lpp_2867 , was highly induced in iron‐restricted conditions. Mutants lacking this gene in L . pneumophila were not affected in siderophore synthesis or utilization. On the contrary, they were defective for growth on iron‐depleted solid media and for ferrous iron uptake. A sequence analysis predicts that L pp_2867 is a membrane protein, suggesting that it is involved in ferrous iron transport. We thus named it IroT , for iron transporter. Infection assays showed that the mutants are highly impaired in intracellular growth within their environmental host A canthamoeba castellanii and human macrophages. Taken together, our results show that IroT is involved, directly or indirectly, in ferrous iron transport and is a key virulence factor for L . pneumophila .
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Gene ipp_2867 was highly induced in L. pneumophila under Fe-restricted conditions.
“In 2014, Portier and Cols discovered gene ipp_2867, which was highly induced in Fe-restricted conditions.”
From Strategies of intracellular pathogens for obtaining iron from the environment (2015) · cites this paper as [49]
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- Authors
- Portier, E., Zheng, H., Sahr, T., Burnside, D. M., Mallama, C., Buchrieser, C., Cianciotto, N. P., & Héchard, Y.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Northwestern University (US)
- Corresponding author
- Héchard, Yann
- Venue
- Environmental Microbiology
- Publisher
- Wiley
- Published
- 2014-09-15
- Volume
- 17
- Issue
- 4
- Pages
- 1338-1350
- ISSN
- 1462-2912 (ISSN-L)
- 1462-2920
- PMC
- PMC4672373
- OpenAlex
- W1937698200
- Cited by
- 49
- References
- 48
- Citations by year
- 2026: 4 · 2024: 2 · 2023: 4 · 2022: 5 · 2021: 5 · 2020: 2 · 2019: 2 · 2018: 8 · 2017: 7 · 2016: 3 · 2015: 6 · 2014: 1
- FWCI
- 3.99
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Environmental Microbiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion, cc-by-nc)
- Funders
- Fondation pour la Recherche Médicale
- Agence Nationale de la Recherche
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Legionella and Acanthamoeba research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Infections and bacterial resistance
- Keywords
- Legionella pneumophila, iron regulation, ferrous iron transport, iron starvation, virulence, Acanthamoeba castellanii, macrophages, intracellular growth, siderophores, membrane proteins, transcriptomics
- MeSH terms
- Amoeba, Bacterial Proteins, Base Sequence, Biological Transport, Humans, Iron, Legionnaires' Disease, Macrophages, Membrane Proteins, Molecular Sequence Data, Virulence, Legionella pneumophila, Virulence Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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