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Growth and Development Following Prenatal Stress Exposure in Primates: An Examination of Ontogenetic Vulnerability
Abstract
Previous studies have found that stressful events during pregnancy can influence the developing fetus, resulting in attentional and neuromotor problems. This prospective study examined whether periods of vulnerability exist for neurobehavioral impairments associated with prenatal stress, using a nonhuman primate model. Twenty-eight rhesus monkey infants were born to mothers in 3 groups: (1) early gestation stress involving mild psychological stress from gestational days 45–90, (2) mid-late gestation stress from days 90–145, and (3) undisturbed controls. Infants were separated from their mothers on days 4, 9, 15, and 22 (±1) postpartum for growth and neurobehavioral assessments. Results indicated that infants from the early gestation stress condition weighed less than infants from mothers stressed during mid-late gestation. Moreover, whereas both groups scored lower than controls on measures of attention and neuromotor maturity, early gestation stress was associated with more pronounced and more pervasive motor impairments than mid-late gestation stress. These results suggest sensitivity to prenatal stress effects peaks during early gestation, tapering off during mid-late gestation. Clarifying the period of greatest vulnerability to prenatal stress moves toward elucidating the underlying mechanism for prenatal stress effects and may lead to more successful intervention and/or prevention.
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“This possibility has been supported by observations in rhesus monkeys, where prenatal exposure to the same stressor had greater effects on postnatal motor development if it occurred earlier in gestation, when neuronal migration was at its peak, than if it occurred in mid- to late gestation, when synaptogenesis was at its peak (Schneider et al., 1999).”
From High pregnancy anxiety during mid-gestation is associated with decreased gray matter density in 6-9-year-old children. (2010) · cites this paper as Schneider et al., 1999
In the citing paper
“Given that brain regions undergoing the most extensive maturation are thought to be the most vulnerable to insult (Schneider et al., 1999), we might expect differing effects of ELS based on developmental timing.”
From The effects of early life stress on reward processing (2018) · cites this paper as Schneider et al., 1999
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Metadata
- Authors
- Schneider, M. L., Roughton, E. C., Koehler, A. J., & Lubach, G. R.
- Affiliations
- University of Wisconsin–Madison (US)
- ORCID
- Lubach, Gabriele R
- Venue
- Child Development
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-03-01
- Volume
- 70
- Issue
- 2
- Pages
- 263-274
- ISSN
- 0009-3920 (ISSN-L)
- 1467-8624
- OpenAlex
- W1991706811
- Cited by
- 267
- References
- 50
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 6 · 2020: 7 · 2019: 11 · 2018: 10 · 2017: 5 · 2016: 7 · 2015: 13 · 2014: 12 · 2013: 12 · 2012: 21
- FWCI
- 12.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Child Development (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r03mh048417-02)
- U.S. Public Health Service (MCJ-009102)
- National Institute on Alcohol Abuse and Alcoholism (AA10079, R01AA010079)
- National Institute of Mental Health (MH48417)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- prenatal stress, rhesus monkeys, infant growth, neurobehavioral development, attention, neuromotor development, early pregnancy, maternal stress, maternal separation
- MeSH terms
- Animals, Animals, Newborn, Animals, Suckling, Birth Weight, Developmental Disabilities, Female, Handling, Psychological, Hydrocortisone, Macaca mulatta, Male, Motor Skills, Orientation, Pregnancy, Prenatal Exposure Delayed Effects, Stress, Psychological, Maternal Exposure
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