Parkinson’s disease as a result of aging
Rodriguez, Manuel, Rodriguez‐Sabate, Clara, Morales, Ingrid, Sanchez, Alberto, Sabate, Magdalena·2015·Aging Cell
Cites (396)
Items 201–396 of 396
- Locus coeruleus cell loss in the aging human brain: A non‐random processK. Manaye, D. McIntire, David M. A. Mann, D. German · 1995 · The Journal of comparative neurology
- Interaction of 1‐Methyl‐4‐Phenylpyridinium Ion (MPP+) and Its Analogs with the Rotenone/Piericidin Binding Site of NADH DehydrogenaseRona Ruth Ramsay, Matthew J. Krueger, Stephen K. Youngster · 1991 · Journal of Neurochemistry
- Protective effects and mechanisms of sirtuins in the nervous systemZhang, Feng, Wang, Suping, Gan, Li, Vosler, Peter S., Gao, Yanqin, Zigmond, Michael J., Chen, Jun · 2011 · Progress in Neurobiology
- Glutathione and Parkinson's disease: Is this the elephant in the room?Gail Duffy Zeevalk, Roozbeh Razmpour, Laura P. Bernard · 2008 · Biomedicine & Pharmacotherapy
- Ageing muscle: clonal expansions of mitochondrial DNA point mutations and deletions cause focal impairment of mitochondrial functionFayet, Guillemette, Jansson, Monica, Sternberg, Damien, Moslemi, Ali-Reza, Blondy, Patricia, Lombès, Anne, Fardeau, Michel, Oldfors, Anders · 2002 · Neuromuscular Disorders
- MiR-146a as marker of senescence-associated pro-inflammatory status in cells involved in vascular remodellingFabiola Olivieri, Raffaella Lazzarini, Rina Recchioni, Fiorella Marcheselli, Maria Rita Rippo, Silvia Nuzzo, Maria Cristina Albertini, Laura Graciotti, Lucia Babini, Serena Mariotti et al. · 2012 · AGE
- Evidence of active microglia in substantia nigra pars compacta of parkinsonian monkeys 1 year after MPTP exposureCarlos Barcia, Angel Sánchez-Bahíllo, Emiliano Fernández‐Villalba, Víctor Bautista‐Hernández, M. Poza, A Fernández-Barreiro, Étienne C. Hirsch, María Trinidad Herrero · 2004 · Glia
- Remarkable longevity and stress resistance of nematode PI3K‐null mutantsSrinivas Ayyadevara, Ramani Alla, John J. Thaden, Robert J. Shmookler Reis · 2007 · Aging Cell
- Ultra-Deep Sequencing of Mouse Mitochondrial DNA: Mutational Patterns and Their OriginsAdam Ameur, James Bruce Stewart, Christoph Freyer, Erik Hagström, Max Ingman, Nils‐Göran Larsson, Ulf B Gyllensten · 2011 · PLoS Genetics
- Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insultsMitsugi Okawara, Hiroshi Katsuki, Emi Kurimoto, Haruki Shibata, Toshiaki Kume, Akinori Akaike · 2006 · Biochemical Pharmacology
- Marked disparity between age‐related changes in dopamine and other presynaptic dopaminergic markers in human striatumJohn W. Haycock, Laurence Edward Becker, Lee Cyn Ang, Yoshiaki Furukawa, Oleh Hornykiewicz, Stephen J. Kish · 2003 · Journal of Neurochemistry
- Oxidative Stress and MicroRNAs in Vascular DiseasesAlessandra Magenta, Simona Greco, Carlo Gaetano, Fabio Martelli · 2013 · International Journal of Molecular Sciences
- Mitochondria as a central sensor for axonal degenerative stimuliFelipe A. Court, Michael P. Coleman · 2012 · Trends in Neurosciences
- Whole-Body Lifetime Occupational Lead Exposure and Risk of Parkinson’s DiseaseSteven W. Coon, Azadeh T. Stark, Edward L. Peterson, Aime M Gloi, Gene X. Kortsha, Joel G. Pounds, David R. Chettle, Jay M. Gorell · 2006 · Environmental Health Perspectives
- Clinical Phenotype of Families with LongevityGil Atzmon, Clyde B. Schechter, William Greiner, Deborah E. Davidson, Gad Rennert, Nir Barzilai · 2004 · Journal of the American Geriatrics Society
- Neuropathology of sporadic Parkinson disease before the appearance of parkinsonism: preclinical Parkinson diseaseIsidró Ferrer, Anna Martinez, Rosa E. Blanco, Esther Dalfó, Margarita Carmona · 2010 · Journal of Neural Transmission
- Mitochondrial involvement in Parkinson's diseaseMichael Orth · 2002 · Neurochemistry International
- Homozygous deletions in parkin gene in European and North African families with autosomal recessive juvenile parkinsonismC.B. Lücking, N. Abbas, Alexandra Dürr, Vincenzo Bonifati, Anne Marie Bonnet, T. de Broucker, Giuseppe De Michele, Nicholas William Wood, Yves Agid, Alexis Brice · 1998 · The Lancet
- Age-related Changes in Locus Ceruleus on Neuromelanin Magnetic Resonance Imaging at 3 TeslaEri Shibata, Makoto Sasaki, Koujiro Tohyama, Yoshiyuki Kanbara, Kotaro Otsuka, Shigeru Ehara, Akio SAKAI · 2006 · Magnetic Resonance in Medical Sciences
- Dietary oxyresveratrol prevents parkinsonian mimetic 6-hydroxydopamine neurotoxicityJianfei Chao, Man-Shan Yu, Janice Yuen Shan Ho, Mingfu Wang, Raymond Chuen‐Chung Chang · 2008 · Free Radical Biology and Medicine
- Iron metabolism in Parkinsonian syndromesDaniela Berg, Helmine Hochstrasser · 2006 · Movement Disorders
- A brief history of levodopaOleh Hornykiewicz · 2010 · Journal of Neurology
- Morphometry of the human substantia nigra in ageing and Parkinson’s diseaseGay L. Rudow, Richard O’Brien, Alena V. Savonenko, Susan M. Resnick, Alan B. Zonderman, Olga Pletniková, Laura Marsh, Ted M. Dawson, Barbara J. Crain, Mark J. West et al. · 2008 · Acta Neuropathologica
- The mitochondrial theory of aging: Insight from transgenic and knockout mouse modelsYoungmok Charles Jang, Holly Van Remmen · 2009 · Experimental Gerontology
- The comparative biology of neuromelanin and lipofuscin in the human brainKay L. Double, Vadim N. Dedov, Heidi Fedorow, Emma Kettle, Glenda Margaret Halliday, Brett Garner, Ulf T. Brunk · 2008 · Cellular and Molecular Life Sciences
- Imaging serotonin and dopamine transporters with 123I-beta-CIT SPECT: binding kinetics and effects of normal aging.Walter Pirker, Susanne Asenbaum, M Hauk, Susanne Kandlhofer, Johannes T. Tauscher, Matthäus Willeit, Alexander Neumeister, Nicole Praschak-Rieder, Peter Angelberger, Th. Brücke · 2000 · PubMed
- Stabilization of α-Synuclein Protein with Aging and Familial Parkinson's Disease-Linked A53T MutationWenxue Li, Christian Lesuisse, Yanqun Xu, Juan Carlos Troncoso, Donald L. Price, Michael K. Lee · 2004 · Journal of Neuroscience
- Increased Oxidative Damage and Decreased Antioxidant Function in Aging Human Substantia Nigra Compared to Striatum: Implications for Parkinson’s DiseaseC. Venkateshappa, Gangadharappa Harish, Rajeswara Babu Mythri, Anita Mahadevan, M. M. Srinivas Bharath, S.K. Shankar · 2011 · Neurochemical Research
- Parkinson's Disease: Activity of L-Dopa Decarboxylase in Discrete Brain RegionsKenneth G. Lloyd, Oleh Hornykiewicz · 1970 · Science
- Interleukin-6 in the aging brainJonathan P. Godbout, Rodney W. Johnson · 2003 · Journal of Neuroimmunology
- Glutathione Peroxidase 4 is associated with Neuromelanin in Substantia Nigra and Dystrophic Axons in Putamen of Parkinson's brainFrederick P. Bellinger, Miyoko T. Bellinger, Lucia A. Seale, Andrea S. Takemoto, Arjun V. Raman, Takanori Miki, Amy Manning-Bog, Marla J. Berry, Lon R. White, G Ross · 2011 · Molecular Neurodegeneration
- Age-related changes in glial fibrillary acidic protein mRNA in the mouse brainJames R. Goss, Caleb E. Finch, David Gene Morgan · 1991 · Neurobiology of Aging
- Astrocytes aged <i>in vitro</i> show a decreased neuroprotective capacityPertusa, M., García‐Matas, S., Rodríguez‐Farré, E., Sanfeliu, C., Cristòfol, R. · 2007 · Journal of Neurochemistry
- MicroRNAs in Parkinson's diseaseM. Maral Mouradian · 2012 · Neurobiology of Disease
- Proteome analysis of human substantia nigra in Parkinson's diseaseCornelius Johannes Werner, Roland Heyny‐von Haußen, Gerhard Mall, Sabine Wolf · 2008 · Proteome Science
- Thalamic changes in Parkinson's diseaseGlenda Margaret Halliday · 2009 · Parkinsonism & Related Disorders
- Critical Evaluation of the Free Radical Theory of AgingByung Pal Yu, Ryung Yang · 1996 · Annals of the New York Academy of Sciences
- Environmental stress, ageing and glial cell senescence: a novel mechanistic link to Parkinson's disease?Chinta, S. J., Lieu, C. A., DeMaria, M., Laberge, R.‐M., Campisi, J., Andersen, J. K. · 2013 · Journal of Internal Medicine
- Mitochondrial involvement in Alzheimer’s diseaseEduardo Bonilla, Kurenai Tanji, Michio Hirano, Tuan Vu, Salvatore DiMauro, Eric A. Schon · 1999 · Biochimica et Biophysica Acta (BBA) - Bioenergetics
- Persistent organochlorine pesticides in serum and risk of Parkinson diseaseMarc G. Weisskopf, Paul Knekt, Éilis J. O’Reilly, Jukka Lyytinen, Antti Reunanen, Francine Laden, Larisa Altshul, Alberto Ascherio · 2010 · Neurology
- Prenatal exposure to the bacteriotoxin lipopolysaccharide leads to long term losses of dopamine neurons in offspring a potential new model of parkinson s diseasePaul M. Carvey · 2003 · Frontiers in bioscience
- Mitochondrial biogenesis in the axons of vertebrate peripheral neuronsMandana Amiri, Peter J. Hollenbeck · 2008 · Developmental Neurobiology
- MicroRNAs in Parkinson's diseaseMaged M. Harraz, Ted M. Dawson, Valina Lynn Dawson · 2011 · Journal of Chemical Neuroanatomy
- Monoamine Metabolism in Human BrainDonald S. Robinson · 1977 · Archives of General Psychiatry
- Oxidative Stress and Parkinson's DiseaseaA Owen, Anthony H.V. Schapira, Peter G. Jenner, C. DAVID MARSDEN · 1996 · Annals of the New York Academy of Sciences
- Microglial degeneration in the aging brain - bad news for neurons?Streit, Wolfgang, J. · 2008 · Frontiers in Bioscience
- A set of miRNAs participates in the cellular senescence program in human diploid fibroblastsRaffaella Faraonio, Paolo Salerno, Fabiana Passaro, Carla Sedia, Annalisa Iaccio, Roberto Bellelli, Tito Claudio Nappi, Marika Comegna, S Romano, Giuliana Salvatore et al. · 2011 · Cell Death and Differentiation
- Ageing of substantia nigra in humans: cell loss may be compensated by hypertrophyC. R. Cabello, Jens Jakob Thune, Henning Pakkenberg, Bente Pakkenberg · 2002 · Neuropathology and Applied Neurobiology
- The Role of Oxidative Stress in the Aging ProcessBárbara Fonseca de Oliveira, José Augusto Nogueira‐Machado, Mı́riam Martins Chaves · 2010 · The Scientific World JOURNAL
- A Morphometric Study of Age-Dependent Changes in Mitochondrial Populations of Mouse Liver and HeartGeorge H. Herbener · 1976 · Journal of Gerontology
- Spermidine and spermine are enriched in whole blood of nona/centenariansPucciarelli, Stefania, Moreschini, Benedetta, Micozzi, Daniela, De Fronzo, Giusi S., Carpi, Francesco M., Polzonetti, Valeria, Vincenzetti, Silvia, Mignini, Fiorenzo, Napolioni, Valerio · 2012 · Rejuvenation Research
- Diverse cellular and molecular modes of axon degenerationLukas Jakob Neukomm, Marc R. Freeman · 2014 · Trends in Cell Biology
- Glutathione release from cultured brain cells: Multidrug resistance protein 1 mediates the release of GSH from rat astroglial cellsJohannes Hirrlinger, Jörg Bernhard Schulz, Ralf Dringen · 2002 · Journal of Neuroscience Research
- Dopamine receptor subtype imbalance in schizophreniaEllen J. Hess, H. Stefan Bracha, Joel E. Kleinman, Ian Creese · 1987 · Life Sciences
- Up-regulation of key microRNAs, and inverse down-regulation of their predicted oxidative phosphorylation target genes, during aging in mouse brainNa Li, David J. Bates, Jin An, Derek A. Terry, Eugenia Wang · 2009 · Neurobiology of Aging
- Increase in Dopamine Turnover Occurs Early in Parkinson's Disease: Evidence from a New Modeling Approach to PET 18 F-Fluorodopa DataVesna Sossi, Raúl de la Fuente‐Fernández, James E. Holden · 2002 · Journal of Cerebral Blood Flow & Metabolism
- Neuronal Death and Survival Under Oxidative Stress in Alzheimer and Parkinson DiseasesAkihiko Nunomura, Paula Isabel Moreira, Hyoung‐gon Lee, X. Zhu, Rudy J. Castellani, Mark A. Smith, George L. Perry · 2007 · CNS & Neurological Disorders - Drug Targets
- Emerging restorative treatments for Parkinson's diseaseTomas Deierborg, Denis Soulet, Laurent Roybon, Vanessa Jane Hall, Patrik Brundin · 2008 · Progress in Neurobiology
- Akt Suppresses Retrograde Degeneration of Dopaminergic Axons by Inhibition of MacroautophagyHsiao-Chun Cheng, Sang Ryong Kim, Tinmarla Frances Oo, Tatyana Kareva, Olga Yarygina, Margarita Rzhetskaya, Chuansong Wang, Matthew J. During, Zsolt Tallóczy, Keiji Tanaka et al. · 2011 · Journal of Neuroscience
- Increases of glial fibrillary acidic protein in the aging female mouse brainSteven G. Kohama, James R. Goss, Caleb E. Finch, Thomas H. McNeill · 1995 · Neurobiology of Aging
- Spatiotemporal Changes to the Subventricular Zone Stem Cell Pool through AgingBrett A. Shook, David H. Manz, John Jeffrey Peters, Sang‐Wook Kang, Joanne C. Conover · 2012 · Journal of Neuroscience
- Genome-environment interactions that modulate aging: powerful targets for drug discoveryde Magalhães, João Pedro, Wuttke, Daniel, Wood, Shona H., Plank, Michael, Vora, Chintan · 2012 · Pharmacological Reviews
- The locus coeruleus and its possible role in ageing and degenerative disease of the human central nervous systemMann, David M.A. · 1983 · Mechanisms of Ageing and Development
- Mitochondrial production of pro-oxidants and cellular senescenceRajindar S. Sohal, Ulf T. Brunk · 1992 · Mutation Research/DNAging
- Effect of cocaine self-administration on dopamine D2 receptors in rhesus monkeysRodney J. Moore, Sharon L. Vinsant, Michael A. Nader, Linda J. Porrino, David P. Friedman · 1998 · Synapse
- Sex differences in behavioral despair: Relationships between behavioral despair and open field activitySimeona J. Alonso, Miguel Angel Castellano, Daruez Afonso, Manuel Rodrı́guez · 1991 · Physiology & Behavior
- Unbiased morphometrical measurements show loss of pigmented nigral neurones with ageingMa, Röytt, Collan, Rinne · 1999 · Neuropathology and Applied Neurobiology
- 1-Methyl-4-phenylpyridinium affects fast axonal transport by activation of caspase and protein kinase CGerardo A. Morfini, Gustavo F. Pigino, K. Opalach, Yafell Serulle, Jorge E. Moreira, Mutsuyuki Sugimori, Rodolfó R. Llinás, Scott T. Brady · 2007 · Proceedings of the National Academy of Sciences
- Biphasic and Region-Specific MAO-B Response to Aging in Normal Human BrainJosep Saura, Noemí Andrés, C Andrade, Júlia Ojuel, K Eriksson, Nicole Mahy · 1997 · Neurobiology of Aging
- Mitochondrial DNA analysis: polymorphisms and pathogenicityPatrick Francis Chinnery, Neil Howell, Richard M. Andrews, Douglass M. Turnbull · 1999 · Journal of Medical Genetics
- Kleemeier Award Lecture: Are There Genes for Aging?Richard A. Miller · 1999 · The Journals of Gerontology Series A
- Selective cell death in neurodegeneration: Why are some neurons spared in vulnerable regions?Kay L. Double, Stefanie Reyes, Eryn L. Werry, Glenda Margaret Halliday · 2010 · Progress in Neurobiology
- The Etiopathogenesis of Parkinson Disease and Suggestions for Future Research. Part IIrene Litvan, Glenda Margaret Halliday, Mark Hallett, Christopher G. Goetz, Walter A. Rocca, Charles J. Duyckaerts, Yoav Ben‐Shlomo, Dennis W. Dickson, Anthony Edward Lang, Marie‐Françoise Chesselet et al. · 2007 · Journal of Neuropathology & Experimental Neurology
- Mitophagy in neurodegeneration and agingKonstantinos Palikaras, Nektarios Tavernarakis · 2012 · Frontiers in Genetics
- Aging of the nigrostriatal system in the squirrel monkeyAlison L. McCormack, Donato A. Di Monte, Kioumars Delfani, Ian Irwin, Louis E. DeLanney, J. William Langston, A. M. Janson · 2004 · The Journal of Comparative Neurology
- The human locus coeruleus complex: an immunohistochemical and three dimensional reconstruction studyKerry Graeme Baker, I. T�rk, Jean‐Pierre Hornung, Paul Halasz · 1989 · Experimental Brain Research
- Genetics of Parkinson's disease and biochemical studies of implicated gene productsPeter T. Lansbury, Alexis Brice · 2002 · Current Opinion in Genetics & Development
- Effects of age on dopamine transporters in healthy humans.P. David Mozley, Paul D. Acton, Elizabeth D. Barraclough, Karl Plößl, Ruben C. Gur, Abass A. Alavi, Anil Mathur, Janet R. Saffer, Hank F. Kung · 1999 · PubMed
- Therapeutic Effects of Rapamycin on MPTP-Induced Parkinsonism in MiceKangyong Liu, Nan Shi, Yinyi Sun, Ting Zhang, Xiaojiang Sun · 2012 · Neurochemical Research
- Dopamine Cell Degeneration Induced by Intraventricular Administration of 6-Hydroxydopamine in the Rat: Similarities with Cell Loss in Parkinson's DiseaseManuel Rodrı́guez, Pedro Barroso‐Chinea, Patricio Abdala, Jose Angel Obeso, Tomás González‐Hernández · 2001 · Experimental Neurology
- Modulation of SIRT1 expression in different neurodegenerative models and human pathologiesMercè Pallàs, Javier G. Pizarro, Javier Cuesta, Natàlia Crespo‐Biel, Daniel Alvira, Marta Tajes, Marc Yeste‐Velasco, Jaume Folch, Anna Maria Canudas, Francesc Xavier Sureda et al. · 2008 · Neuroscience
- A STUDY OF SELECTED CATECHOLAMINE METABOLIZING ENZYMES: A COMPARISON OF DEPRESSIVE SUICIDES AND ALCOHOLIC SUICIDES WITH CONTROLS1S. S. Grote, Sylvia G. Moses, Eli Robins, Richard W. Hudgens, Adele B. Croninger · 1974 · Journal of Neurochemistry
- Histological changes of the dopaminergic nigrostriatal system in agingAmy K. Stark, Bente Pakkenberg · 2004 · Cell and Tissue Research
- LongevityMap: a database of human genetic variants associated with longevityArie Budovsky, Thomas Craig, Jingwei Wang, Robi Tăcutu, Attila Csordás, Joana Lourenço, Vadim E. Fraifeld, João Pedro de Magalhães · 2013 · Trends in Genetics
- Parkinson's disease as multifactorial oxidative neurodegeneration: implications for integrative management.P M Kidd · 2000 · PubMed
- Stress‐Induced Premature Senescence: Essence of Life, Evolution, Stress, and AgingOlivier Toussaint, PATRICK DUMONT, Jean‐François Dierick, Thierry G. Pascal, Christophe C. Frippiat, Florence Debacq‐Chainiaux, Francis E. Sluse, François Eliaers, José Remacle · 2000 · Annals of the New York Academy of Sciences
- Neurogenesis in the aging brainKunlin Jin · 2008 · Clinical Interventions in Aging
- The impact of glial activation in the aging brain.Aileen M. Lynch, Kevin J Murphy, Brian F. Deighan, Julie-Ann O’Reilly, Yurii K. Gun’ko, Thelma R. Cowley, Rodrigo E. González-Reyes, Marina A. Lynch · 2010 · Europe PMC (PubMed Central)
- Basic Research on Dopamine in Parkinson’s Disease and the Discovery of the Nigrostriatal Dopamine Pathway: The View of an EyewitnessOleh Hornykiewicz · 2008 · Neurodegenerative Diseases
- Changes in somatodendritic but not terminal dopamine regulation in aged rhesus monkeysGreg A. Gerhardt, Wayne A. Cass, Yi Ai, Zhiming Zhang, Don Marshall Gash · 2001 · Journal of Neurochemistry
- Age-related changes of astorocytes, oligodendrocytes and microglia in the mouse hippocampal CA1 sectorNatsumi Hayakawa, Hiroyuki Kato, Tsutomu Araki · 2007 · Mechanisms of Ageing and Development
- Locus ceruleus morphometry in aging and schizophreniaJames B. Lohr, Dilip V. Jeste · 1988 · Acta Psychiatrica Scandinavica
- Increased levels of proinflammatory cytokines in the aged rat brain attenuate injury‐induced cytokine response after excitotoxic damageÓscar Campuzano, Maria del Mar Castillo-Ruiz, Laia Acarín, Bernardo Castellano, Berta González · 2009 · Journal of Neuroscience Research
- The co‐occurrence of mt DNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specificNicola Raule, Federica Sevini, Shengting Li, Annalaura Barbieri, Federica Tallaro, Laura Lomartire, Dario Vianello, Alberto Montesanto, Jukka S. Moilanen, Vladislav V Bezrukov et al. · 2013 · Aging Cell
- Emerging roles of microglial activation and non-motor symptoms in Parkinson's diseaseKarlijn J. Doorn, Paul John Lucassen, H. W. G. M. Boddeke, Marloes Prins, Henk W. Berendse, Benjamin Drukarch, Anne‐Marie van Dam · 2012 · Progress in Neurobiology
- Mitochondrial function, fibre types and ageing: new insights from human muscle in vivoKevin E. Conley, Catherine E. Amara, Sharon A. Jubrias, David Joseph Marcinek · 2006 · Experimental Physiology
- Qualitative and quantitative analysis of locus coeruleus neurons in Parkinson's disease.E Bertrand, Waldemar Lechowicz, Grazyna Maria Szpak, Jerzy Dymecki · 1997 · PubMed
- Behavioral lateralization in rats: prenatal stress effects on sex differencesJosefina Alonso, Miguel Angel Castellano, Manuel Rodrı́guez · 1991 · Brain Research
- Staging of Sporadic Parkinson Disease-Related α-Synuclein Pathology: Inter- and Intra-Rater ReliabilityChristian M. Müller, Rob A. I. de Vos, Claude‐Alain Maurage, Dietmar Rudolf Thal, Markus Tolnay, Heiko Braak · 2005 · Journal of Neuropathology & Experimental Neurology
- Comparative analysis of the effects of resveratrol in two apoptotic models: Inhibition of complex I and potassium deprivation in cerebellar neuronsDaniel Alvira, Marc Yeste‐Velasco, Jaume Folch, Ester Verdaguer, Anna Maria Canudas, Mercè Pallàs, Antoni Camins · 2007 · Neuroscience
- AGING OF THE SUBVENTRICULAR ZONE NEURAL STEM CELL NICHE.Joanne C. Conover, Brett A. Shook · 2011 · Europe PMC (PubMed Central)
- The Impact of Pathogenic Mitochondrial DNA Mutations on Substantia Nigra NeuronsAmy Katherine Reeve, Martin Meagher, Nicola Lax, Eve M. Simcox, Philippa D. Hepplewhite, Evelyn Jaros, Douglass M. Turnbull · 2013 · Journal of Neuroscience
- Age-dependent axonal transport and locomotor changes and tau hypophosphorylation in a “P301L” tau knockin mouseJonathan Gilley, Anjan Seereeram, Kunié Ando, Suzanne I.S. Mosely, Simon Andrews, Martin Kerschensteiner, Thomas Misgeld, Jean‐Pierre Brion, Brian H. Anderton, Diane P. Hanger et al. · 2011 · Neurobiology of Aging
- Relation of aging with oxidative protein damage parameters in the rat skeletal muscleUfuk Çakatay, Ayşegül Telci, Refik Kayalı, Fatma Tekeli, Tülay Akçay, Ahmet Sıvas · 2003 · Clinical Biochemistry
- Selective autophagy in the maintenance of cellular homeostasis in aging organismsVanessa M. Hubbard, Rut Valdor, Fernando Macián, Ana María Cuervo · 2011 · Biogerontology
- Attenuation of 6-hydroxydopamine-induced dopaminergic nigrostriatal lesions in superoxide dismutase transgenic miceMasato Asanuma, Hiroshi Hirata, Jean Lud Cadet · 1998 · Neuroscience
- The PINK1 phenotype can be indistinguishable from idiopathic Parkinson diseaseAlberto Albanese, Enza Maria Valente, Luigi Michele Romito, Emanuele Bellacchio, Antonio Emanuele Elia, Bruno Dallapiccola · 2005 · Neurology
- Monoamine re-uptake sites in the human brain evaluatedin vivoby means of11C-nomifensine and positron emission tomography: the effects of age and Parkinson's diseaseJoakim Tedroff, Sten‐Magnus Aquilonius, P. Hartvig, Hans Lundqvist, Antony D. Gee, J. Uhlin, Bengt Långström · 1988 · Acta Neurologica Scandinavica
- Selective vulnerability of pigmented dopaminergic neurons in Parkinson's diseaseÉtienne C. Hirsch, Ann M. Graybiel, Yves Agid · 1989 · Acta Neurologica Scandinavica
- Mortality, oxidative stress and tau accumulation during ageing in parkin null miceJosé Antonio Rodríguez‐Navarro, Marı́a José Casarejos, Jaime Menéndez, Rosa Maria Solano, Izaskun Rodal, Ana Gómez, Justo Garcı́a de Yébenes, María A. Mena · 2007 · Journal of Neurochemistry
- Aging‐related changes in astrocytes in the rat retina: imbalance between cell proliferation and cell death reduces astrocyte availabilityMansour, Hussein, Chamberlain, Coral G., Weible II, Michael W., Hughes, Suzanne, Chu, Yi, Chan‐Ling, Tailoi · 2008 · Aging Cell
- The ageing epigenome: Damaged beyond repair?David A. Sinclair, Philipp Oberdoerffer · 2009 · Ageing Research Reviews
- Challenging conventional wisdom: The etiologic role of dopamine oxidative stress in Parkinson's diseaseJ. Eric Ahlskog · 2004 · Movement Disorders
- A Morphometric Study of the Density of Mitochondrial Cristae in Heart and Liver of Aging MiceE. L. Tate, George H. Herbener · 1976 · Journal of Gerontology
- Divergent changes in D-1 and D-2 dopamine binding sites in human brain during agingDavid Gene Morgan, Jan O. Marcusson, Per Nyberg · 1987 · Neurobiology of Aging
- Age‐related accumulation of Marinesco bodies and lipofuscin in rhesus monkey midbrain dopamine neurons: Relevance to selective neuronal vulnerabilityNicholas M. Kanaan, Jeffrey H. Kordower, Timothy J. Collier · 2007 · The Journal of Comparative Neurology
- Somatic mitochondrial DNA mutations in single neurons and gliaIppolita Cantuti‐Castelvetri, Michael T. S. Lin, Kangni Zheng, Christine E. Keller-McGandy, Rebecca A. Betensky, Donald R. Johns, M. Flint Beal, David G. Standaert, David K. Simon · 2004 · Neurobiology of Aging
- The mitochondrial genome in aging and senescenceLauri, Andrea, Pompilio, Giulio, Capogrossi, Maurizio C. · 2014 · Ageing Research Reviews
- There is no such thing as agingRichard Peto, Richard Doll · 1997 · BMJ
- Oxidative stress and Parkinson's diseasePeter G. Jenner · 2007 · Handbook of clinical neurology
- Age-related neuronal loss in the rat brain starts at the end of adolescenceMorterá, Priscilla, Herculano-Houzel, Suzana · 2012 · Frontiers in Neuroanatomy
- The Effect of Age on Mitochondrial UltrastructurePatricia D. Wilson, L. M. Franks · 2009 · Gerontologia
- Motor behavioural changes after intracerebroventricular injection of 6-hydroxydopamine in the rat: an animal model of Parkinson's diseaseManuel Rodrı́guez, Patricio Abdala, Pedro Barroso‐Chinea, Jose Angel Obeso, Tomás González‐Hernández · 2001 · Behavioural Brain Research
- Parkinson's disease and family historyA Sellbach, Richard S. Boyle, Peter A. Silburn, George D. Mellick · 2006 · Parkinsonism & Related Disorders
- Comparison of two-dimensional electrophoresis patterns of heat shock protein Hsp27 species in normal and cardiomyopathic heartsChristian Scheler, Xinping Li, Johann Salnikow, Michael James Dunn, Peter Roman Jungblut · 1999 · Electrophoresis
- Impairment of axonal transport in the axon hillock and the initial segment of anterior horn neurons in transgenic mice with a G93A mutant SOD1 geneShoichi Sasaki, Hitoshi Warita, Koji Abe, Makoto Iwata · 2005 · Acta Neuropathologica
- Ageing and neurotoxins as causative factors in idiopathic parkinson's disease—a critical analysis of the neurochemical evidenceOleh Hornykiewicz · 1989 · Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Dopaminergic neuronal injury in the adult rat brain following neonatal exposure to lipopolysaccharide and the silent neurotoxicityLir‐Wan Fan, Lu‐Tai Tien, Baoying Zheng, Yi Pang, Rick C.S. Lin, Kimberly L. Simpson, Tangeng Ma, Philip G. Rhodes, Zhengwei Cai · 2010 · Brain Behavior and Immunity
- Molecular and cellular gerontology Serpiano, Switzerland, September 18–22, 1999Ch. Brack, Gordon J. Lithgow, Heinz Osiewacz, Olivier Toussaint · 2000 · The EMBO Journal
- Electrophysiological and Morphological Evidence for a GABAergic Nigrostriatal PathwayManuel Rodrı́guez, Tomás González‐Hernández · 1999 · Journal of Neuroscience
- Role of Sirtuins and Calorie Restriction in Neuroprotection: Implications in Alzheimers and Parkinsons DiseasesSarika Srivastava, Marcia C. Haigis · 2011 · Current Pharmaceutical Design
- On the immortality of the germ line: Genetic and biochemical mechanisms. A reviewЖорес Александрович Медведев · 1981 · Mechanisms of Ageing and Development
- Colocalization of tyrosine hydroxylase and GAD65 mRNA in mesostriatal neuronsTomás González‐Hernández, Pedro Barroso‐Chinea, Abraham Acevedo‐Arozena, EDUARDO C. SALIDO, Manuel Rodrı́guez · 2001 · European Journal of Neuroscience
- Immunocytochemical Quantification of Tyrosine Hydroxylase at a Cellular Level in the Mesencephalon of Control Subjects and Patients with Parkinson's and Alzheimer's DiseaseAnne Kästner, Étienne C. Hirsch, María Trinidad Herrero, France Javoy-Agid, Yves Agid · 1993 · Journal of Neurochemistry
- Unmyelinated axons are more vulnerable to degeneration than myelinated axons of the cardiac nerve in Parkinson's diseaseSatoshi Orimo, Toshiki Uchihara, T. Kanazawa, Yasuhiro Itoh, Koichi Wakabayashi, Akiyoshi Kakita, Hitoshi Takahashi · 2011 · Neuropathology and Applied Neurobiology
- Primary vs. secondary recurrent pregnancy loss – epidemiological characteristics, etiology, and next pregnancy outcomeEfrat Shapira, Ronit Ratzon, Ilana Shoham‐Vardi · 2012 · Journal of Perinatal Medicine
- Mitochondrial Microheteroplasmy and a Theory of Aging and Age-Related DiseaseRafal M. Smigrodzki, Shaharyar M. Khan · 2005 · Rejuvenation Research
- The mtDNA mutator mouse: Dissecting mitochondrial involvement in agingDaniel Edgar, Aleksandra Trifunović · 2009 · Aging
- ‘Senescence‐associated’ β‐galactosidase activity in the upper gastrointestinal tractJames J. Going, Robert C. Stuart, Martin Downie, Aileen J. Fletcher‐Monaghan, W. Nicol Keith · 2002 · The Journal of Pathology
- 6‐[18F]Fluoro‐L‐DOPA probes dopamine turnover rates in central dopaminergic structuresJorge R. Barrio, Siyuan Huang, William P. Melega · 1990 · Journal of Neuroscience Research
- Selective injury to dopaminergic neurons up-regulates GDNF in substantia nigra postnatal cell cultures: Role of neuron–glia crosstalkAna Saavedra, Graça Baltazar, Paulo Rodrigues‐Santos, Caetana Monteiro Carvalho, Emı́lia P. Duarte · 2006 · Neurobiology of Disease
- Is aging programed?Steven N. Austad · 2004 · Aging Cell
- Evidence for specific phases in the development of human neuromelaninGlenda Margaret Halliday, Heidi Fedorow, C. H. Rickert, M. Gerlach, Peter Franz Riederer, Kay L. Double · 2006 · Journal of Neural Transmission
- Aging of the rat mesostriatal system: Differences between the nigrostriatal and the mesolimbic compartmentsIgnacio Cruz‐Muros, Domingo Afonso‐Oramas, Pedro M. Abreu, Pedro Barroso‐Chinea, Manuel Rodrı́guez, M. Carmen González, Tomás González‐Hernández · 2006 · Experimental Neurology
- Programmed ageing: the theory of maximal metabolic scopeRoland Prinzinger · 2005 · EMBO Reports
- Parkinson's disease, pesticides and individual vulnerabilityMoreno Paolini, Andrea Sapone, Frank J. Gonzalez · 2004 · Trends in Pharmacological Sciences
- Sir-2.1 modulates ‘calorie-restriction-mediated’ prevention of neurodegeneration in Caenorhabditis elegans: Implications for Parkinson’s diseasePooja Jadiya, Manavi Chatterjee, Shreesh Raj Sammi, Supinder Kaur, Gautam Palit, Aamir Nazir · 2011 · Biochemical and Biophysical Research Communications
- Clinical correlates of serum insulin-like growth factor-1 in patients with Parkinson's disease, multiple system atrophy and progressive supranuclear palsyAyaka Numao, Keisuke Suzuki, Masayuki Miyamoto · 2013 · Parkinsonism & Related Disorders
- Molecular mechanisms of ageing and related diseasesJunping Liu · 2014 · Clinical and Experimental Pharmacology and Physiology
- Age‐related changes in dopamine transporters and accumulation of 3‐nitrotyrosine in rhesus monkey midbrain dopamine neurons: Relevance in selective neuronal vulnerability to degenerationNicholas M. Kanaan, Jeffrey H. Kordower, Timothy J. Collier · 2008 · European Journal of Neuroscience
- Dynamic transport and localization of alpha-synuclein in primary hippocampal neuronsMong-Lin Yang, Linda Hasadsri, Wendy S. Woods, Julia M. George · 2010 · Molecular Neurodegeneration
- Neonatal exposure to lipopolysaccharide enhances vulnerability of nigrostriatal dopaminergic neurons to rotenone neurotoxicity in later lifeLir‐Wan Fan, Lu‐Tai Tien, Rick C.S. Lin, Kimberly L. Simpson, Philip G. Rhodes, Zhengwei Cai · 2011 · Neurobiology of Disease
- Mitochondrial DNA content contributes to healthy aging in Chinese: a study from nonagenarians and centenariansYonghan He, Xiang Lu, Huan Wu, Wangwei Cai, Li-Qin Yang, Liang‐You Xu, Hongpeng Sun, Qing‐Peng Kong · 2014 · Neurobiology of Aging
- Increased dopamine synthesis in aging substantia nigra neuronsCarol E. Greenwood, W. G. Tatton, Nadine A. Seniuk · 1991 · Neurobiology of Aging
- Senescence-accelerated Mice (SAMs) as a Model for Brain Aging and Immunosenescence.Atsuyoshi Shimada, Sanae Hasegawa‐Ishii · 2011 · Europe PMC (PubMed Central)
- The Etiopathogenesis of Parkinson Disease and Suggestions for Future Research. Part IIIrene Litvan, Marie‐Françoise Chesselet, Thomas Gasser, Donato A. Di Monte, Davis Parker, Theo Hagg, John Hardy, Peter G. Jenner, Richard H. Myers, Donald D. Price et al. · 2007 · Journal of Neuropathology & Experimental Neurology
- Aging risk factors and Parkinson's disease: contrasting roles of common dietary constituentsAlan R. Hipkiss · 2013 · Neurobiology of Aging
- Neonatal Systemic Exposure to Lipopolysaccharide Enhances Susceptibility of Nigrostriatal Dopaminergic Neurons to Rotenone Neurotoxicity in Later LifeZhengwei Cai, Lir‐Wan Fan, Asuka Kaizaki, Lu‐Tai Tien, Tangeng Ma, Yi Pang, Shuying Lin, Rick C.S. Lin, Kimberly L. Simpson · 2013 · Developmental Neuroscience
- The role of non-synaptic extracellular glutamateManuel Rodrı́guez, Magdalena Sabaté, Clara Rodriguez‐Sabate, Ingrid Moráles · 2012 · Brain Research Bulletin
- The biological significance of meiosis.R. Holliday · 1984 · PubMed
- Behavioral and metabolic characterization of heterozygous and homozygous POLG mutator miceYing Dai, Tomas Kiselak, Joanne Clark, Elizabeth L. Clore, Kangni Zheng, Allen A. Cheng, Gregory C. Kujoth, Tomas A. Prolla, Eleftheria Maratos–Flier, David K. Simon · 2013 · Mitochondrion
- Parkinson-Linked Genes and Toxins That Affect Neuronal Cell Death Through the Bcl-2 FamilyDouglas W. Ethell, Qingyan Fei · 2008 · Antioxidants and Redox Signaling
- The Yin-Yang of SirtuinsAndrew G. Dillin, Jeffery W. Kelly · 2007 · Science
- The Role of Microglial Cellular Senescence in the Aging and Alzheimer Diseased BrainFlanary, Barry · 2005 · Rejuvenation Research
- Autoimmune Encephalomyelitis and Uveitis Induced by T Cell Immunity to Self β-SynucleinFelix Mor, Francisco Javier Quintana, Avishai Mimran, Irun R. Cohen · 2003 · The Journal of Immunology
- Screening for DJ-1 mutations in early onset autosomal recessive parkinsonismP. Ibáñez, Giuseppe De Michele, Vincenzo Bonifati et al. · 2003 · Neurology
- Gastrointestinal, urological, and sexual dysfunction in Parkinson's diseaseRonald F. Pfeiffer · 2010 · Movement Disorders
- A Novel Look at AstrocytesAndreas F. Mack, Hartwig Wolburg · 2012 · The Neuroscientist
- Parkinson's disease-associated human P5B-ATPase ATP13A2 increases spermidine uptakeDiego Pablo de la Hera, Gerardo Raul Corradi, Hugo Pedro Adamo, Felicitas de Tezanos Pinto · 2012 · Biochemical Journal
- The glia doctrine: Addressing the role of glial cells in healthy brain ageingErlend Arnulf Nagelhus, Mahmood Reza Amiry-Moghaddam, Linda Hildegard Bergersen, Jan Gunnar Bjaalie, Jens Eriksson, Vidar Gundersen, Trygve Brauns Leergaard, Jens Preben Morth, Jon Storm‐Mathisen, Reidun Torp et al. · 2013 · Mechanisms of Ageing and Development
- Comparison of dopamine transporter decline in a patient with Parkinson's disease and normal aging effectKenji Ishibashi, Keiichi Oda, Kiichi Ishiwata, Kenji Ishii · 2014 · Journal of the Neurological Sciences
- Astrocytes as neural stem cells in the adult brain.Óscar González-Pérez, Alfredo Quiñones‐Hinojosa · 2012 · PubMed
- Astrocyte-neuron interactionsEduardo Elias Benarroch · 2009 · Neurology
- PPAR-α Expression Inversely Correlates with Inflammatory Cytokines IL-1β and TNF-α in Aging RatsDavid S. Gélinas, JoAnne McLaurin · 2005 · Neurochemical Research
- A review of why and how we age: A defense of multifactorial agingCharles B. Olson · 1987 · Mechanisms of Ageing and Development
- iPSCs, aging and age-related diseasesKen‐ichi Isobe, Zhao Cheng, Naomi Nishio, Suganya Thanasegaran, Yuriko Tanaka, Sachiko Ito · 2014 · New Biotechnology
- Deglycosylation and subcellular redistribution of VMAT2 in the mesostriatal system during normal agingIgnacio Cruz‐Muros, Domingo Afonso‐Oramas, Pedro M. Abreu, Manuel Rodrı́guez, M. Carmen González, Tomás González‐Hernández · 2007 · Neurobiology of Aging
- Age-related changes of neuronal counts in the human pedunculopontine nucleusGerhard N. Ransmayr, Baptiste A. Faucheux, C Nowakowski, Nathalie Kubis, S. Federspiel, Walter Anton Kaufmann, Dominique Hénin, J J Hauw, Yves Agid, Étienne C. Hirsch · 2000 · Neuroscience Letters
- Fetal brain serotonin synthesis and catabolism is under control by mother intake of tryptophanR. Arévalo, Daruez Afonso, Rafael Castro, Manuel Rodrı́guez · 1991 · Life Sciences
- Striatal glutamate induces retrograde excitotoxicity and neuronal degeneration of intralaminar thalamic nuclei: their potential relevance for Parkinson's diseaseIngrid Moráles, Magdalena Sabaté, Manuel Rodrı́guez · 2013 · European Journal of Neuroscience
- Self‐induced accumulation of glutamate in striatal astrocytes and basal ganglia excitotoxicityIngrid Moráles, Manuel Rodrı́guez · 2012 · Glia
- Late onset sporadic Parkinson's disease caused by PINK1 mutations: Clinical and functional studyVania Gelmetti, Alessandro Ferraris, Livia Brusa, Francesca Romano, Federica Lombardi, Chiara Barzaghi, Paolo Stanzione, Barbara Garavaglia, Bruno Dallapiccola, Enza Maria Valente · 2008 · Movement Disorders
- Mitochondrial DNA in pathogenesis of Alzheimer's and Parkinson's diseasesAleksandra Maruszak, Katarzyna Gawęda-Walerych, Ireneusz Sołtyszewski, And Zekanowski · 2006 · Acta Neurobiologiae Experimentalis
- Differential Age‐Related Loss of Pigmented Locus Coeruleus Neurons in Suicides, Alcoholics, and Alcoholic SuicidesVictoria Arango, Mark D. Underwood, Donna Pauler Ankerst · 1996 · Alcoholism Clinical and Experimental Research
- Apomorphine lowers dopamine synthesis for up to 48 hManuel Rodrı́guez, Rafael Castro · 1991 · Neuroreport
- PLASMAPHERESIS FOR PARAQUAT POISONINGJacob R. Miller, E. Sanders, D. Webb · 1978 · The Lancet
- Age-related alterations in the protein expression profile of C57BL/6J mouse pituitariesGorji Marzban, Johannes Grillari, Eva Reisinger · 2002 · Experimental Gerontology
- Response of the GABAergic and dopaminergic mesostriatal projections to the lesion of the contralateral dopaminergic mesostriatal pathway in the ratTomás González‐Hernández, Pedro Barroso‐Chinea, Manuel Rodrı́guez · 2004 · Movement Disorders
- [Histochemical study on the regressive degeneration of the senile brain, with special reference to the aging of the substantia nigra].S Hirai · 1968 · PubMed
- An immunohistochemical observation of manganese superoxide dismutase in rat substantia nigra after occlusion of middle cerebral arteryXiaohong Liu, Hiroyuki Kato, Tsutomu Araki, Yasuto Itoyama, Kanefusa Kato, Kyuya Kogure · 1994 · Neuroscience Letters
- Damage to the nigrostriatal system in the MPTP-treated SAMP8 mouseJing Liu, Yanyong Wang, Li Liu, Quandong Wang, Zhen-Yun Yuan, Zhongxia Zhang, Ping Gu, Mingwei Wang · 2008 · Neuroscience Letters
- Is the loss of thalamostriatal neurons protective in parkinsonism?Sheila V. Kusnoor, E. Chris Muly, James I. Morgan, Ariel Y. Deutch · 2009 · Parkinsonism & Related Disorders
- Effect of Gender on Main Clinical Chemistry Parameters in Aged RatsRefik Kayalı, Seval Aydın, Ufuk Çakatay · 2009 · Current Aging Science
- Striatal Glutamate Degenerates Thalamic NeuronsIngrid Moráles, Catalina Yanos, Clara Rodriguez‐Sabate, Alberto Sánchez, Manuel Rodrı́guez · 2013 · Journal of Neuropathology & Experimental Neurology
- Localization of Axonal Motor Molecules Machinery in Neurodegenerative DisordersFulvio Florenzano · 2012 · International Journal of Molecular Sciences
- Untitled work1999 · 10.1002/(sici)1097-4547(19990715)57:2