Astrocyte senescence: Evidence and significance

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Items 201–282 of 282

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5. TLR7 Mediates HIV ‐1 Tat‐Induced Cellular Senescence in Human Astrocytes
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6. Identification of markers for neurescence through transcriptomic profiling of postmortem human brains
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7. IL-33 Regulates the Phenotypic Transformation of Reactive Astrocytes via PENK-ERK/MAPK Pathway in Parkinson’s Disease
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8. Stochastic Nanoscale Biophysical Cues as a Basis for the Induction of Glioblastoma‐Like Transcriptional Programs in Astrocytes
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9. Stage-Dependent Function of Astrocytes in Alzheimer’s Disease: A Review
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11. Cellular senescence: from pathogenic mechanisms to precision anti-aging interventions
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14. Morphological screens using aged primary adult neuronal, microglial, and astrocytic cultures to find novel neurotherapeutics
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15. Engineered Clostridium butyricum-pMTL007-GLP-1 Delays Neurodegeneration in Prnp-SNCA*A53T Transgenic Mice Model by Suppressing Astrocyte Senescence
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16. Cellular Senescence in the Aging Brain
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17. Cobalamin Deficiency May Induce Astrosenescence—An In Vitro Study
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18. Uncovering the Signatures of Cellular Senescence in the Human Dorsolateral Prefrontal Cortex
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19. 3-N-Butylphthalide alleviate Aβ-induced cellular senescence through the CDK2-pRB1-Caspase3 axis
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20. Astrocyte-neuron signaling in aging
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21. miR-103a regulates DNA repair capacity in human astrocytes under oxidative stress through direct OGG1 targeting
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22. PAPP-A-Mediated Proteolytic Cleavage of IGFBP-4 and Age-Related Changes in the Primary Culture of Rat Astrocytes
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23. Astrocyte Senescence Impairs Synaptogenesis due to Thrombospondin‐1 Loss
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24. Senolytic therapy ameliorates high-fat diet-induced hippocampal senescence and cognitive decline in mice
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25. Viral Mimicry of Alzheimer’s Disease: Innate Sensing of Self-Nucleic Acids as a Driver of Glial Senescence
    Qamar Abuhassan, Tamara Nazar Saeed, Ali Fawzi Al-Hussainy, R. Roopashree, Swati Mishra, Anima Nanda, Gunjan Mukherjee, Jasur Rizaev, Sada Ghalib Taher, Mariem Alwan et al. · 2026 · Journal of Molecular Neuroscience
26. Neurovascular unit senescence as a driver of blood–brain barrier dysfunction in Alzheimer’s disease：Mechanisms, consequences, and therapeutic implications
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27. Neuroinflamación mediada por los astrocitos en el envejecimiento y la neurodegeneración a través del factor nuclear ϰβ y el receptor de hidrocarburos de arilo
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28. NeuroHIV and the glymphatic system
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29. Neuronal Stability, Volumetric Changes, and Decrease in GFAP Expression of Marmoset ( Callithrix jacchus ) Subcortical Visual Nuclei During Aging
    Nelyane N. M. Santana, Eryck H. A. Silva, Sâmarah F. dos Santos, Lyzandro L. F. Bezerra, Maria M. O. da Silva, Jeferson S. Cavalcante, Felipe Porto Fiuza, Paulo L. A. de G. Morais, Rovena Clara Galvão Januário Engelberth · 2024 · The Journal of Comparative Neurology
30. Multiplexed single-cell imaging reveals diverging subpopulations with distinct senescence phenotypes during long-term senescence induction
    Garrett A. Sessions, Madeline V. Loops, Brian O. Diekman, Jeremy E. Purvis · 2025 · GeroScience
31. Neurotoxicants driving glial aging: role of astrocytic aging in non-cell autonomous neurodegeneration
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32. Regulation of brain aging by neutral sphingomyelinase 2
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33. Biophysical basis for the induction of glioblastoma-like phenotype in astrocytes
    Laurent Starck, Melika Sarem, Bernd Heimrich, Ritwick Sawarkar, Marie‐Françoise Ritz, Gregor Hütter, Venkatram Prasad Shastri · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
34. Lactate promotes longevity through redox-driven lipid remodeling in Caenorhabditis elegans
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35. Regulation of Proinflammatory Extracellular Vesicles from HIV Infected Cells by CBD
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36. The Role of DNA Damage-induced Cellular Senescence in the Pathophysiology of mTBI
    Nicole Schwab · 2019 · TSpace (University of Toronto)
37. Ингибирование miR-21 способствует процессу старения полученных из клеток NT2 астроцитов
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38. Cellular senescence in the ageing brain
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39. The COVID-19–related neuroinflammation model may reveal relevant information on healthy longevity
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40. Principles of gliopathology
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41. In vivo Analysis of kir4.1 Channel Expression Following Photothrombotic Stroke and Antidepressant Therapy
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42. Role of inflammasomes in HIV-1 and drug abuse-mediated neuroinflammation
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43. Differential Susceptibility to Propofol and Ketamine in Primary Cultures of Young and Senesced Astrocytes
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44. Multiplexed single-cell imaging reveals diverging subpopulations with distinct senescence phenotypes during long-term senescence induction
    Garrett A. Sessions, Madeline V. Loops, Brian O. Diekman, Jeremy E. Purvis · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
45. The role of astrocytes in the temporoammonic pathway: masticatory behavior as a neuroprotective strategy against age-related cognitive decline
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46. Astrocytic Cathepsin D truncates α-synuclein and promotes Lewy neurite-like aggregation in neurons
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47. Senolytic Therapy as a Preventive Strategy for Low Back Pain
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48. Transcription factor NRF2: New therapeutic approach to modify Parkinson's disease progression
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49. Telomere Attrition‐Induced Senescence in Human Pluripotent Stem Cell‐Derived Astrocytes: Distinct Cellular and Functional Characteristics
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50. Additional file 1 of Attenuation of Alzheimer’s brain pathology in 5XFAD mice by PTH1-34, a peptide of parathyroid hormone
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51. Additional file 3 of Attenuation of Alzheimer’s brain pathology in 5XFAD mice by PTH1-34, a peptide of parathyroid hormone
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52. Additional file 2 of Attenuation of Alzheimer’s brain pathology in 5XFAD mice by PTH1-34, a peptide of parathyroid hormone
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53. Additional file 1 of Engrafted glial progenitor cells yield long-term integration and sensory improvement in aged mice
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54. Additional file 1 of Astragaloside IV inhibits astrocyte senescence: implication in Parkinson’s disease
    Xia, Mei-Ling, Xie, Xia-Hong, Ding, Jian-Hua, Du, Ren-Hong, Hu, Gang · 2020 · Figshare
55. Additional file 2 of Engrafted glial progenitor cells yield long-term integration and sensory improvement in aged mice
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56. Additional file 1 of Metformin normalizes mitochondrial function to delay astrocyte senescence in a mouse model of Parkinson’s disease through Mfn2-cGAS signaling
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57. Additional file 1 of Human Alzheimer’s disease reactive astrocytes exhibit a loss of homeostastic gene expression
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58. Additional file 2 of Human Alzheimer’s disease reactive astrocytes exhibit a loss of homeostastic gene expression
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60. Astrocytes in Neurofluid Drainage and Brain Disorders: Mechanisms and Therapeutic Implications
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67. Redox bioenergetics of neuronal senescence in Alzheimer’s disease
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68. Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain
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70. Exosomal TGM2 From Hypoxia‐Primed Olfactory Mucosa MSCs Attenuates Senescent Astrocytes via NRF1 / TFAM Signaling in Parkinson's Disease
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71. The Effects of Gut Microbiome (Microbiota) Changes in Aging on Fragility (Frailty Syndrome), Neurocognitive, and Immune Processes
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75. Astrocytes in Neurodegeneration: Spatial States, Crosstalk, and Emerging Therapies
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78. Astrocytic cathepsin D promotes α-synuclein processing and Lewy neurite-like aggregate maturation
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79. Astrocyte Structure–Function Relationship in Senescence and Neurodegeneration
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82. Ramelteon suppresses astrocytic senescence via MT1-cAMP axis to protect dopaminergic neurons
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