Cited by 282Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsNeuroinflammation and Neurodegeneration Mechanisms

Astrocyte senescence: Evidence and significance

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Cohen, Justin, Torres, Claudio·2019·Aging Cell

Abstract

Astrocytes participate in numerous aspects of central nervous system (CNS) physiology ranging from ion balance to metabolism, and disruption of their physiological roles can therefore be a contributor to CNS dysfunction and pathology. Cellular senescence, one of the mechanisms of aging, has been proposed as a central component of the age dependency of neurodegenerative disorders. Cumulative evidence supports an integral role of astrocytes in the initiation and progression of neurodegenerative disease and cognitive decline with aging. The loss of astrocyte function or the gain of neuroinflammatory function as a result of cellular senescence could have profound implications for the aging brain and neurodegenerative disorders, and we propose the term “astrosenescence” to describe this phenotype. This review summarizes the current evidence pertaining to astrocyte senescence from early evidence, in vitro characterization and relationship to age‐related neurodegenerative disease. We discuss the significance of targeting senescent astrocytes as a novel approach toward therapies for age‐associated neurodegenerative disease.

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Authors
Cohen, J., & Torres, C.
Affiliations
Drexel University (US)
Corresponding author
Torres, Claudio
Venue
Aging Cell
Publisher
Wiley
Published
2019-02-27
Volume
18
Issue
3
Pages
e12937-e12937
ISSN
  • 1474-9718 (ISSN-L)
  • 1474-9726
OpenAlex
W2920249424
Cited by
281
References
127
Citations by year
2026: 43 · 2025: 41 · 2024: 37 · 2023: 48 · 2022: 45 · 2021: 33 · 2020: 27 · 2019: 7
FWCI
3.30
Type
journal article
Language
en
Open access
Locations
  • Aging Cell (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (1RO1NS078283, NS78283, R21AG046943, F31AG054191, 1R56AG056696)
  • Coins for Alzheimer's Research Trust
Topics
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
astrocyte senescence, cellular senescence, astrocytes, neurodegenerative diseases, brain aging, neuroinflammation, cognitive decline, senolytic therapy, central nervous system physiology
MeSH terms
Astrocytes, Humans, Cellular Senescence, Neurodegenerative Diseases

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