Astrocyte senescence: Evidence and significance
Open accessAbstract
Astrocytes participate in numerous aspects of central nervous system (CNS) physiology ranging from ion balance to metabolism, and disruption of their physiological roles can therefore be a contributor to CNS dysfunction and pathology. Cellular senescence, one of the mechanisms of aging, has been proposed as a central component of the age dependency of neurodegenerative disorders. Cumulative evidence supports an integral role of astrocytes in the initiation and progression of neurodegenerative disease and cognitive decline with aging. The loss of astrocyte function or the gain of neuroinflammatory function as a result of cellular senescence could have profound implications for the aging brain and neurodegenerative disorders, and we propose the term “astrosenescence” to describe this phenotype. This review summarizes the current evidence pertaining to astrocyte senescence from early evidence, in vitro characterization and relationship to age‐related neurodegenerative disease. We discuss the significance of targeting senescent astrocytes as a novel approach toward therapies for age‐associated neurodegenerative disease.
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Aging may impact the function of astrocytes and microglia.
“as aging may impact the function of astrocytes (98, 99) and microglia (100)”
From Modeling late-onset Alzheimer’s disease neuropathology via direct neuronal reprogramming (2024) · cites this paper as [99]
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- Authors
- Cohen, J., & Torres, C.
- Affiliations
- Drexel University (US)
- Corresponding author
- Torres, Claudio
- ORCID
- Torres, Claudio
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2019-02-27
- Volume
- 18
- Issue
- 3
- Pages
- e12937-e12937
- ISSN
- 1474-9718 (ISSN-L)
- 1474-9726
- PMC
- PMC6516680
- OpenAlex
- W2920249424
- Cited by
- 281
- References
- 127
- Citations by year
- 2026: 43 · 2025: 41 · 2024: 37 · 2023: 48 · 2022: 45 · 2021: 33 · 2020: 27 · 2019: 7
- FWCI
- 3.30
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Aging Cell (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1RO1NS078283, NS78283, R21AG046943, F31AG054191, 1R56AG056696)
- Coins for Alzheimer's Research Trust
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- astrocyte senescence, cellular senescence, astrocytes, neurodegenerative diseases, brain aging, neuroinflammation, cognitive decline, senolytic therapy, central nervous system physiology
- MeSH terms
- Astrocytes, Humans, Cellular Senescence, Neurodegenerative Diseases
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