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Cited by 44Epigenetics and DNA MethylationTelomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Aging and cancer epigenetics: Where do the paths fork?

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Pérez, Raúl Fernández, Tejedor, Juan Ramón, Fernández, Agustín Fernández, Fraga, Mario Fernández·2022·Aging Cell
DOI 10.1111/acel.13709PMC PMC9577950
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Abstract

Aging and cancer are clearly associated processes, at both the epidemiological and molecular level. Epigenetic mechanisms are good candidates to explain the molecular links between the two phenomena, but recent reports have also revealed considerable differences, particularly regarding the loss of DNA methylation in the two processes. The large‐scale generation and availability of genome‐wide epigenetic data now permits systematic studies to be undertaken which may help clarify the similarities and differences between aging and cancer epigenetic alterations. In addition, the development of epigenetic clocks provides a new dimension in which to investigate diseases at the molecular level. Here, we examine current and future questions about the roles of DNA methylation mechanisms as causal factors in the processes of aging and cancer so that we may better understand if and how aging‐associated epigenetic alterations lead to tumorigenesis. It seems certain that comprehending the molecular mechanisms underlying epigenetic clocks, especially with regard to somatic stem cell aging, combined with applying single‐cell epigenetic‐age profiling technologies to aging and cancer cohorts, and the integration of existing and upcoming epigenetic evidence within the genetic damage models of aging will prove to be crucial to improving understanding of these two interrelated phenomena.

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  • Over the past decade, senescent cells have been shown to promote tumor growth and malignancy through a variety of mechanisms under certain circumstances.

    “However, paradoxically, over the past decade, senescent cells have been shown to promote tumor growth and malignancy through a variety of mechanisms under certain circumstances.229–231”

    From Drug repurposing for cancer therapy (2024) · cites this paper as [231]

    The section on classic aging-associated DNA methylation alterations in cancer says that aging-related changes in the tumor microenvironment may have oncogenic roles, but does not identify senescent cells as the cause. Searches for senescent cells and cellular senescence found no passage in our copy addressing whether such cells promote tumor growth or malignancy through multiple mechanisms. (LLM, conf=0.73)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Pérez, R. F., Tejedor, J. R., Fernández, A. F., & Fraga, M. F.
Affiliations
Consejo Superior de Investigaciones Científicas (ES)
Corresponding author
  • Fernández, Agustín Fernández
  • Fraga, Mario Fernández
ORCID
Venue
Aging Cell
Publisher
Wiley
Published
2022-09-14
Volume
21
Issue
10
Pages
e13709-e13709
ISSN
  • 1474-9718 (ISSN-L)
  • 1474-9726
DOI
10.1111/acel.13709
PMC
PMC9577950
OpenAlex
W4295761495
Cited by
44
References
15
Citations by year
2026: 8 · 2025: 14 · 2024: 8 · 2023: 13 · 2022: 1
FWCI
0.94
Type
journal article
Language
en
Open access
Licence
Locations
  • Aging Cell (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by)
Funders
  • Fundación Bancaria Caja de Ahorros de Asturias
  • Fundación Científica Asociación Española Contra el Cáncer (PROYE18061FERN)
  • Fundación General CSIC (0348_CIE_6_E)
  • Instituto de Salud Carlos III (PI21/01067)
  • Ministerio de Ciencia e Innovación (IJC2018‐36825‐I, SGL2021‐03‐039/40)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords
aging, cancer, epigenetics, DNA methylation, epigenetic clocks, carcinogenesis
MeSH terms
Aging, Humans, Neoplasms, DNA Methylation, Epigenesis, Genetic, Epigenomics

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