The impact of clozapine on hospital use: a systematic review and meta-analysis
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OBJECTIVE: The objective of this study was to perform a systematic review and meta-analysis of studies reporting the impact of clozapine on hospital use in people with a psychotic illness. METHOD: PubMed, EMBASE, PsycINFO and the Cochrane Schizophrenia Group Trials Register were systematically searched from inception to 12 October 2016. We included all trials and observational studies, except case reports. RESULTS: Thirty-seven studies were included. Clozapine significantly reduced the proportion of people hospitalised compared to control medicines (RR = 0.74; 95% CI: 0.69-0.80, P < 0.001, 22 studies, n = 44 718). There were significantly fewer bed days after clozapine treatment compared to before clozapine treatment in both controlled (MD = -34.41 days; 95% CI: -68.22 to -0.60 days, P = 0.046, n = 162) and uncontrolled studies (MD = -52.86 days; 95% CI: -79.86 days to -25.86 days, P < 0.001, n = 2917). Clozapine and control medicines had a similar time to rehospitalisation (-19.90 days; 95% CI: -62.42 to 22.63 days, P = 0.36). CONCLUSION: Clozapine treatment reduced the number of people hospitalised and the number of bed days after treatment compared with before treatment. Clozapine has the potential to reduce acute hospital use among people with treatment refractory schizophrenia.
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A pilot study found that FitBit activity trackers could potentially be used alongside fitness apps in people with schizophrenia to deliver DPP-based interventions.
“For example, a pilot study found that 'FitBit' activity trackers could potentially be used alongside fitness apps in people with schizophrenia to deliver DPP-based interventions, 257”
From The Lancet Psychiatry Commission: a blueprint for protecting physical health in people with mental illness (2019) · cites this paper as [257]
There is emerging evidence that online peer-support platforms, smartphone apps, and fitness trackers can successfully increase walking and physical activity in people with severe mental illness.
“Although there are very few evaluations of mHealth for physical health in mental illness, there is emerging evidence that online peer-support platforms, smartphone apps and fitness trackers can successfully increase walking and physical activity in people with SMI.257,341,342”
From The Lancet Psychiatry Commission: a blueprint for protecting physical health in people with mental illness (2019) · cites this paper as [257]
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- Authors
- Land, R., Siskind, D., McArdle, P., Kisely, S., Winckel, K., & Hollingworth, S. A.
- Affiliations
- The University of Queensland (AU)
- Corresponding author
- Hollingworth, S. A.
- Venue
- Acta Psychiatrica Scandinavica
- Publisher
- Wiley
- Published
- 2017-02-03
- Volume
- 135
- Issue
- 4
- Pages
- 296-309
- ISSN
- 0001-690X (ISSN-L)
- 1600-0447
- OpenAlex
- W2584668464
- Cited by
- 141
- References
- 60
- Citations by year
- 2026: 19 · 2025: 17 · 2024: 13 · 2023: 11 · 2022: 18 · 2021: 17 · 2020: 17 · 2019: 14 · 2018: 13 · 2017: 2
- FWCI
- 1.91
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Acta Psychiatrica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- Griffith Research Online (submittedVersion, other-oa)
- Funders
- National Health and Medical Research Council (APP1111136)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Clinical Psychology › Psychiatric care and mental health services
- Social Sciences › Psychology › Clinical Psychology › Historical Psychiatry and Medical Practices
- Keywords
- clozapine, hospitalization, bed days, hospital readmission, treatment-resistant schizophrenia, psychosis, antipsychotic drugs
- MeSH terms
- Clozapine, Female, Hospitalization, Humans, Male, Psychotic Disorders, Antipsychotic Agents, Randomized Controlled Trials as Topic, Treatment Outcome, Observational Studies as Topic
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